Safety data sheet reference · CAS 67-66-3
Chloroform SDS
also: chloroform MSDS · safety data sheet · CHCl3 · CAS 67-66-3 · EC 200-663-8 · trichloromethane
Official PDF from supplier
This page is a reference, not the legal document.
CAS number
67-66-3
EC number
200-663-8
CLP Annex VI index
602-006-00-4
Molecular formula
CHCl3
Molar mass
119.37 g/mol
§ 02 · Hazards identification
Chloroform harmonised EU classification
CLP Annex VI · Index 602-006-00-4. A supplier SDS may add self-classified hazards — this is the legal minimum.
Precautionary statements
Codes ending in a colon introduce the action that follows — on a label they are printed as combined statements, such as P305+P351+P338.
§ 03 · Composition and identifiers
Chloroform molecular structure
Chloroform is a molecular compound. The skeletal formula below is drawn from its PubChem SMILES string, and every value in this section is computed from that structure.
2D skeletal formula · CHCl3
Functional group
halide
Hybridisation
C sp³ · Cl sp³ ×3
Molecular geometry
tetrahedral · 109.5° ideal
Electron count
26 valence e⁻ · 9 lone pairs
Identifiers from PubChem (NIH, public domain). Structure diagram drawn with RDKit from the SMILES string. Geometry and hybridisation are computed from the connection table, not measured.
§ 04 · First-aid measures
Chloroform first aid measures
Call your national emergency number first. These are published first-aid measures, not medical advice, and they do not replace emergency services, a poison control centre or the supplier's safety data sheet.
§4–§6 below reproduce the CAMEO Chemicals entry CHLOROFORM. CAMEO publishes response data per product entry, so the entry can describe a solution, a refrigerated liquid or a molten form rather than the pure substance in §9 — check it matches what you are handling.
Signs and Symptoms of Chloroform Exposure: Signs and symptoms of acute exposure to chloroform vapor may include conjunctivitis and blepharospasm (twitching of the eyelid). Burning pain and corneal epithelium injury may occur from chloroform liquid splashed in the eye. Acute exposure may also lead to respiratory depression, chemical pneumonitis, pulmonary edema, metabolic acidosis, central nervous system depression, headache, fatigue, and dizziness. Gastrointestinal signs and symptoms include nausea, vomiting, salivation, anorexia, and gastrointestinal irritation. Cardiac arrhythmias and cardiac arrest have been reported.
Emergency Life-Support Procedures: Acute exposure to chloroform may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to chloroform. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for performance of invasive procedures. 4. Transport to a health care facility.
Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to chloroform. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 30 minutes. 5. Wash exposed skin areas thoroughly with water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Transport to a health care facility.
Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility.
Source: EPA, 1998 — via CAMEO Chemicals (NOAA), public domain.
§ 05 · Fire-fighting measures
Chloroform fire fighting measures
ERG 2024 · GUIDE 151 Substances - Toxic (Non-Combustible)ERG guidance is written per response guide, not per substance — Guide 151 covers every material assigned to it, so a few sentences reference other UN numbers in the same group.
Fire and explosion hazard
Container may explode in the heat of fire. When heated it liberates phosgene, hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine. Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) and dinitrogen tetroxide. It reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide. It is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine. It reacts vigorously with triisopropylphosphine. It develops acidity from prolonged exposure to air and light.
Extinguishing media and tactics
Wear self-contained breathing apparatus and special protective clothing. Move container from fire area. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
Extinguish with dry chemical, carbon dioxide, water spray, fog or foam.
Source: EPA, 1998 — via CAMEO Chemicals (NOAA), public domain. Entry: CHLOROFORM.
§ 06 · Accidental release measures
Chloroform spill and leak response
Containment and clean-up
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust.
Initial isolation and evacuation
IMMEDIATE PRECAUTIONARY MEASUREIsolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILLIncrease the immediate precautionary measure distance, in the downwind direction, as necessary.
FIREIf tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Source: ERG, 2024 — via CAMEO Chemicals (NOAA), public domain. Entry: CHLOROFORM.
§ 07 · Handling and storage
Chloroform computed storage compatibility
Derived from CLP Annex VI classification and CAMEO reactive-group data — not copied from a PDF.
↔ Keep separate
Full interactive verdict — reactions, gas release on contact, ADR forms →
§ 08 · Exposure controls
Chloroform exposure limits (IDLH)
IDLH
Immediately Dangerous to Life or Health
500 ppm
Carcinogen
NIOSH lists chloroform as a potential occupational carcinogen — exposure should be kept as low as achievable regardless of the IDLH figure.
NIOSH Pocket Guide — Chloroform →
IDLH from the NIOSH Pocket Guide to Chemical Hazards (CDC, U.S. public domain), via CAMEO Chemicals. Occupational exposure limits — OSHA PEL, NIOSH REL and EU IOELV — are not published on this page yet.
§ 09 · Physical and chemical properties
Chloroform physical properties
Source: CAMEO Chemicals (NOAA, public domain); per-value source references stored in the database.
§ 10 · Stability and reactivity
Reactive group (CAMEO/NOAA): Halogenated Organic Compounds. Our database documents 17 incompatible and 13 caution reaction-partner groups for chloroform — including which combinations release gas on contact. See the per-partner breakdown with gas release →
17
Incompatible
13
Caution
§ 13 · Disposal considerations
Dispose of waste and residues in accordance with local and national regulations — in the EU under the Waste Framework Directive 2008/98/EC. Never discharge to drains or municipal waste; hand contaminated packaging and unused product to an authorised waste-disposal company. The supplier's SDS section 13 lists the applicable waste codes for the specific product.
§ 14 · Transport information
Chloroform road transport — ADR 2025
UN number
Proper shipping name
CHLOROFORM
Class · PG
6.1 · III
Classification code
T1
Transport category
2
ADR labels
6.1
Hazard ID (Kemler) / UN plate
Top: hazard identification number (Kemler). Bottom: UN number — as carried on the orange plate of the transport unit.
Source: UN ADR 2025 (ECE/TRANS/352), Table A. Road (ADR) only — for sea (IMDG) and air (IATA), consult the supplier's SDS §14.
MSDS vs SDS
Chloroform MSDS vs SDS: is there a difference?
MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the format is set by REACH Annex II. So a "chloroform MSDS" and a "chloroform SDS" refer to the same document — today it is issued as an SDS. Full breakdown of the differences →
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Substance profile
What chloroform is
Physical and chemical properties with the conditions each value was measured under, synonyms, formula and the harmonised CLP classification →
Compliance hub
From classification to SDS
The classification above corresponds to Section 2 of a Safety Data Sheet. Learn how a compliant 16-section SDS is structured and authored →
GHS label maker
Build the label for chloroform
Pictograms, signal word and H-statements combined into a compliant label layout →
§ 16 · Sources
- Classification: Regulation (EC) No 1272/2008 (CLP), Annex VI
- Transport: UN ADR 2025 (UNECE), Table A
- Reactivity: NOAA CAMEO Chemicals reactive-group matrix (public domain)
- Physical properties: CAMEO Chemicals (NOAA, public domain) — per-value source references stored in the database
- Emergency response (§4–§6): ERG 2024 (PHMSA) · NIOSH Pocket Guide (CDC) · CHRIS (USCG) · NTP · EPA — via CAMEO Chemicals (NOAA), all US federal public domain, reproduced verbatim
- Substance data: PubChem · ECHA
Reference aid only. This page summarises the harmonised EU classification and computed storage guidance — it is not a Safety Data Sheet and does not replace one. Always verify hazards, handling and storage against the supplier's SDS (sections 7 and 10) and local regulations before use. Page updated 2026-08-11.
Frequently asked questions about chloroform
Is an MSDS the same as an SDS?
In practice, yes. MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the SDS format is set by REACH Annex II. A document you find labelled "chloroform MSDS" is today issued as an SDS.
What GHS pictograms does chloroform require?
Under the harmonised EU classification (CLP Annex VI), chloroform carries GHS06 and GHS08 with the signal word "Danger". Hazard statements: H351, H361d, H331, H302, H372, H315, H319. A supplier's SDS may add self-classified hazards on top of this harmonised minimum.
Where can I download an official chloroform SDS PDF?
From your own supplier — an SDS is issued per product and supplier, so the correct PDF for an inspection is the one matching the product you actually purchased. The supplier links on this page lead to the official SDS libraries of major distributors.
Call emergency services first
112 in the EU · 911 in the US. This screen is published response information, not medical advice, and it does not replace emergency services, a poison centre or the supplier's safety data sheet.
Text below is the CAMEO Chemicals entry CHLOROFORM — confirm it matches the form in front of you.
01 · First aid
What to do for the person
Signs and Symptoms of Chloroform Exposure: Signs and symptoms of acute exposure to chloroform vapor may include conjunctivitis and blepharospasm (twitching of the eyelid). Burning pain and corneal epithelium injury may occur from chloroform liquid splashed in the eye. Acute exposure may also lead to respiratory depression, chemical pneumonitis, pulmonary edema, metabolic acidosis, central nervous system depression, headache, fatigue, and dizziness. Gastrointestinal signs and symptoms include nausea, vomiting, salivation, anorexia, and gastrointestinal irritation. Cardiac arrhythmias and cardiac arrest have been reported.
Emergency Life-Support Procedures: Acute exposure to chloroform may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to chloroform. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for performance of invasive procedures. 4. Transport to a health care facility.
Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to chloroform. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 30 minutes. 5. Wash exposed skin areas thoroughly with water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Transport to a health care facility.
Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility.
02 · Fire
Extinguishing and tactics
Fire and explosion hazard
Container may explode in the heat of fire. When heated it liberates phosgene, hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine. Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) and dinitrogen tetroxide. It reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide. It is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine. It reacts vigorously with triisopropylphosphine. It develops acidity from prolonged exposure to air and light.
Extinguishing media and tactics
Wear self-contained breathing apparatus and special protective clothing. Move container from fire area. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
Extinguish with dry chemical, carbon dioxide, water spray, fog or foam.
03 · Spill
Containment, isolation, evacuation
Containment and clean-up
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust.
Initial isolation and evacuation
IMMEDIATE PRECAUTIONARY MEASUREIsolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILLIncrease the immediate precautionary measure distance, in the downwind direction, as necessary.
FIREIf tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Sources: ERG 2024 (PHMSA) · NIOSH Pocket Guide (CDC) · CHRIS (USCG) · NTP · EPA — via CAMEO Chemicals (NOAA), public domain. Text reproduced verbatim.