Substance profile
Acetophenone
Acetophenone is a colorless liquid with a sweet pungent odor.
01 · Identification
What Acetophenone is
Acetophenone is a colorless liquid with a sweet pungent odor. It boils at 202 °C, melts at 19.4 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
Acetophenone identifiers and molecular data
Acetophenone CAS number and EC number
Acetophenone molecular formula and molecular weight
03 · GHS classification
Acetophenone hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Acetophenone pictograms and signal word
Acetophenone hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
Acetophenone hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H302 | Harmful if swallowed. |
| H319 | Causes serious eye irritation. |
This page lists only the codes assigned to Acetophenone. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Acetophenone
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Acetophenone issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Acetophenone precautionary statements
CLP Annex VI assigns 10 precautionary statements to Acetophenone. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Acetophenone name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | ацетофенон |
| Spanish español | Acetofenona |
| Czech čeština | acetofenon |
| Danish dansk | acetophenon |
| German Deutsch | Acetophenon Methyl-phenylketon |
| Estonian eesti | atsetofenoon |
| Greek ελληνικά | ακετοφαινόνη |
| English English | acetophenone |
| French français | acétophénone |
| Croatian hrvatski | acetofenon |
| Italian italiano | acetofenone |
| Latvian latviešu | acetofenons |
| Lithuanian lietuvių | acetofenonas |
| Hungarian magyar | acetofenon |
| Maltese Malti | aċetofenon |
| Dutch Nederlands | acetofenon |
| Polish polski | acetofenon |
| Portuguese português | acetofenona |
| Romanian română | acetofenonă |
| Slovak slovenčina | acetofenón |
| Slovenian slovenščina | acetofenon |
| Finnish suomi | asetofenoni |
| Swedish svenska | acetofenon |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Acetophenone GHS label elements
Everything CLP Annex VI fixes for Acetophenone, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Acetophenone
- Harmful if swallowed.
- Causes serious eye irritation.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF IN EYES:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Acetophenone in the GHS label constructor →
07 · Health hazards
Acetophenone health hazards and exposure limits
Acetophenone hazard summary
Acetophenone is used for fragrance in soaps and perfumes, as a flavoring agent in foods, and as a solvent for plastics and resins. Acute (short-term) exposure to acetophenone vapor may produce skin irritation and transient corneal injury in humans. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of acetophenone in humans. EPA has classified acetophenone as a Group D, not classifiable as to human carcinogenicity.
Source: EPA Hazardous Air Pollutants
Acetophenone carcinogenicity classification
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity
Source: Hazardous Substances Data Bank (HSDB)
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on no human data and no animal data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: None.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Acetophenone properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Acetophenone boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 202.1 °C (395.8 °F) | HSDB | |
| 201.72 °C (395.1 °F) | at 760 mmHg | CAMEO | |
| 202 °C (395.6 °F) | ICSC |
Acetophenone melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 19.4 °C (66.9 °F) | HSDB | |
| 19.72 °C (67.5 °F) | CAMEO | ||
| 20 °C (68 °F) | ICSC |
Acetophenone density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.03 g/cm³ | ICSC | |
| 1.0281 g/cm³ | at 20 °C | HSDB | |
| 1.028 g/cm³ | at 20 °C | CAMEO |
Acetophenone solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in water | HSDB | |
| Slightly soluble in concentrated sulfuric acid with orange color; freely soluble in alcohol, chloroform, ether, fatty oils, glycerol | HSDB | ||
| In water, 6,130 mg/L at 25 °C | at 25 °C | HSDB |
Acetophenone vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.2 mmHg | at 20 °C | DOE PAC |
| 0.397 mmHg | at 25 °C | HSDB | |
| 0.9976 mmHg | at 15 °C | ICSC |
Acetophenone flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 76 °C (168.8 °F) | HSDB | |
| 76.67 °C (170 °F) | HSDB | ||
| 77 °C (170.6 °F) | HSDB |
Acetophenone autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 570 °C (1058 °F) | HSDB | |
| 535 °C (995 °F) | ICSC |
Acetophenone lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.1 % by volume | percent by volume | HSDB |
| 1.1 % by volume | CAMEO | ||
| 1 % by volume | estimated | ICSC |
Acetophenone upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 6.7 % by volume | percent by volume | HSDB |
| 6.7 % by volume | CAMEO | ||
| 5.2 % by volume | estimated | ICSC |
Acetophenone vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.1 (air = 1) | HSDB |
Acetophenone odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | 0.8347 mg/cu m (odor low) 2.9460 (odor high) | HSDB | |
| 65.0 ppm/water | HSDB | ||
| Odor Threshold Low: 0.17 [ppm] | Haz-Map |
Acetophenone critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 427.78 °C (802 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Acetophenone fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Acetophenone fire potential
Combustible.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Acetophenone storage and handling
Acetophenone peroxide formation
D*: Other compounds that may form peroxides
Source: Lab and Research Safety, University of Minnesota
Acetophenone safe storage
Separated from strong oxidants and strong bases. Ventilation along the floor.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Acetophenone storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive. Store under inert gas.
Source: Hazardous Substances Data Bank (HSDB)
Acetophenone incompatible materials
Incompatible materials: Strong oxidizing agents, strong bases, strong reducing agents.
Source: Hazardous Substances Data Bank (HSDB)
Acetophenone reactivity
ACETOPHENONE reacts with many acids and bases liberating heat and flammable gases (e.g., H2). Reacts with many oxidizing agents. Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. The amount of heat in these reactions may be sufficient to start a fire in the unreacted portion. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Acetophenone in the storage compatibility matrix →
11 · Questions
Acetophenone — frequently asked questions
What is the CAS number of Acetophenone?
The CAS number of Acetophenone is 98-86-2. Its EC number is 202-708-7.
What does a Acetophenone label have to show?
Under CLP Annex VI the label for Acetophenone carries the pictogram Exclamation mark and the signal word is Warning.
Is Acetophenone flammable?
CLP Annex VI assigns Acetophenone no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 76 °C (168.8 °F) (HSDB).
Is Acetophenone a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Acetophenone. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Acetophenone?
The boiling point reported for Acetophenone is 202.1 °C (395.8 °F) (HSDB).
What is the melting point of Acetophenone?
The melting point reported for Acetophenone is 19.4 °C (66.9 °F) (HSDB).
How should Acetophenone be stored?
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive. Store under inert gas. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Acetophenone
Keep going: substances starting with A, or search the whole database by name, CAS number, pictogram or signal word.