Substance profile
Methyl acetoacetate
Methyl acetoacetate is a colorless liquid with an agreeable odor.
01 · Identification
What Methyl acetoacetate is
Methyl acetoacetate is a colorless liquid with an agreeable odor. It boils at 172 °C, melts at -80 °C, is soluble in water.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Methyl acetoacetate identifiers and molecular data
Methyl acetoacetate CAS number and EC number
03 · GHS classification
Methyl acetoacetate hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Methyl acetoacetate pictograms and signal word
Methyl acetoacetate hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
Methyl acetoacetate hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H319 | Causes serious eye irritation. |
This page lists only the codes assigned to Methyl acetoacetate. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Methyl acetoacetate
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Methyl acetoacetate issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Methyl acetoacetate precautionary statements
CLP Annex VI assigns 6 precautionary statements to Methyl acetoacetate. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Methyl acetoacetate name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | метилов ацетоацетат |
| Spanish español | Acetoacetato de metilo |
| Czech čeština | methyl-acetoacetát |
| Danish dansk | methylacetoacetat |
| German Deutsch | Methylacetoacetat Acetessigsäuremethylester |
| Estonian eesti | metüülatsetoatsetaat |
| Greek ελληνικά | ακετοξικός μεθυλεστέρας ακετοξικό μεθύλιο |
| English English | methyl acetoacetate |
| French français | acétoacétate de méthyle |
| Croatian hrvatski | metil-acetoacetat |
| Italian italiano | metile acetoacetato |
| Latvian latviešu | metilacetoacetāts |
| Lithuanian lietuvių | metilacetoacetatas |
| Hungarian magyar | metil-acetoacetát |
| Maltese Malti | aċetoaċetat tal-metil |
| Dutch Nederlands | methylacetoacetaat |
| Polish polski | acetylooctan metylu ester metylowy kwasu acetylooctowego |
| Portuguese português | acetoacetato de metilo |
| Romanian română | aceto-acetat de metil |
| Slovak slovenčina | metyl-acetoacetát O -metyl-3-oxobutanoát |
| Slovenian slovenščina | metil acetoacetat |
| Finnish suomi | metyyliasetoasetaatti |
| Swedish svenska | metylacetoacetat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Methyl acetoacetate GHS label elements
Everything CLP Annex VI fixes for Methyl acetoacetate, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Methyl acetoacetate
- Causes serious eye irritation.
- Wash … thoroughly after handling.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF IN EYES:
- Get medical advice/attention.
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Methyl acetoacetate in the GHS label constructor →
07 · Health hazards
Methyl acetoacetate health hazards and exposure limits
Methyl acetoacetate hazard summary
A skin, eye, and respiratory tract irritant; May cause CNS depression; [ICSC] An eye irritant; [CAMEO] A severe eye irritant based on animal studies; [CHEMINFO] An irritant; [MSDSonline]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Methyl acetoacetate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Methyl acetoacetate boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 171.7 °C (341.1 °F) | HSDB | |
| 169.44 °C (337 °F) | range, midpoint shown, at 760 mmHg | CAMEO |
Methyl acetoacetate melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -80 °C (-112 °F) | HSDB | |
| -27 °C (-16.6 °F) | ICSC |
Methyl acetoacetate density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.076 g/cm³ | CAMEO | |
| 1.0762 g/cm³ | at 20 °C | HSDB | |
| 1.0784 g/cm³ | at 20 °C | HSDB |
Methyl acetoacetate solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in 2 parts water; miscible with alcohol and ether | HSDB | |
| SOLUBILITY IN WATER: 38 G/100 ML | HSDB | ||
| Solubility in water, g/100ml: 50 | ICSC |
Methyl acetoacetate vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 1.2751 mmHg | at 20 °C | ICSC |
| 0.892 mmHg | at 25 °C, Extrapolated | HSDB | |
| 0.89 mmHg | Haz-Map |
Methyl acetoacetate flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 76.67 °C (170 °F) | HSDB | |
| 70 °C (158 °F) | CAMEO | ||
| 77 °C (170.6 °F) | ICSC |
Methyl acetoacetate autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 280 °C (536 °F) | HSDB |
Methyl acetoacetate lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 3.1 % by volume | CAMEO | |
| 1.4 % by volume | ICSC |
Methyl acetoacetate upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 16 % by volume | CAMEO | |
| 14.5 % by volume | ICSC |
Methyl acetoacetate vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4 (air = 1) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Methyl acetoacetate fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Methyl acetoacetate fire potential
FIRE HAZARD: Moderate, when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Methyl acetoacetate storage and handling
Methyl acetoacetate safe storage
Separated from oxidants.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Methyl acetoacetate reactivity
METHYL ACETOACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Methyl acetoacetate in the storage compatibility matrix →
11 · Questions
Methyl acetoacetate — frequently asked questions
What is the CAS number of Methyl acetoacetate?
The CAS number of Methyl acetoacetate is 105-45-3. Its EC number is 203-299-8.
What does a Methyl acetoacetate label have to show?
Under CLP Annex VI the label for Methyl acetoacetate carries the pictogram Exclamation mark and the signal word is Warning.
Is Methyl acetoacetate flammable?
CLP Annex VI assigns Methyl acetoacetate no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 76.67 °C (170 °F) (HSDB).
Is Methyl acetoacetate a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Methyl acetoacetate. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Methyl acetoacetate?
The boiling point reported for Methyl acetoacetate is 171.7 °C (341.1 °F) (HSDB).
What is the melting point of Methyl acetoacetate?
The melting point reported for Methyl acetoacetate is -80 °C (-112 °F) (HSDB).
Nearby
Substances next to Methyl acetoacetate
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