Substance profile
Papaverine
Papaverine is white prisms from alcohol-diethyl ether; needles from petroleum ether.
01 · Identification
What Papaverine is
Papaverine is white prisms from alcohol-diethyl ether; needles from petroleum ether. Its molecular formula is C20H21NO4 and its molecular weight is 339.4 g/mol. It boils at 135 °C, melts at 148 °C.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Papaverine identifiers and molecular data
Papaverine CAS number and EC number
Papaverine molecular formula and molecular weight
03 · GHS classification
Papaverine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Papaverine pictograms and signal word
Papaverine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
Papaverine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H302 | Harmful if swallowed. |
This page lists only the codes assigned to Papaverine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Papaverine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Papaverine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Papaverine precautionary statements
CLP Annex VI assigns 4 precautionary statements to Papaverine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Papaverine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | папаверин |
| Spanish español | Papaverina |
| Czech čeština | papaverin |
| Danish dansk | papaverin |
| German Deutsch | Papaverin 1-(3',4'-Dimethoxy-benzyl)-6,7-dimethoxy-isochinolin |
| Estonian eesti | papaveriin |
| Greek ελληνικά | παπαβερίνη |
| English English | papaverine |
| French français | papavérine |
| Croatian hrvatski | papaverin |
| Italian italiano | papaverina |
| Latvian latviešu | papaverīns |
| Lithuanian lietuvių | papaverinas |
| Hungarian magyar | papaverin |
| Maltese Malti | papaverina |
| Dutch Nederlands | papaverine |
| Polish polski | papaweryna |
| Portuguese português | papaverina |
| Romanian română | papaverină |
| Slovak slovenčina | papaverín 1-(3,4-dimetoxybenzyl)-6,7-dimetoxyizochinolín |
| Slovenian slovenščina | papaverin |
| Finnish suomi | papaveriini |
| Swedish svenska | papaverin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Papaverine GHS label elements
Everything CLP Annex VI fixes for Papaverine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Papaverine
- Harmful if swallowed.
- Do not eat, drink or smoke when using this product.
- IF SWALLOWED:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Rinse mouth.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Papaverine in the GHS label constructor →
07 · Physical and chemical properties
Papaverine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Papaverine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 135 °C (275 °F) | sublimes | HSDB |
Papaverine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 147.5 °C (297.5 °F) | HSDB | |
| 224.5 °C (436.1 °F) | HSDB | ||
| 226 (dec) °C | DrugBank |
Papaverine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.337 g/cm³ | at 20 °C | HSDB |
Papaverine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in water; very soluble in ethanol, chloroform; soluble in acetone, benzene, pyridine | HSDB | |
| Almost insoluble in water. Soluble in hot benzene, glacial acetic acid, acetone; slightly soluble in chloroform, carbon tetrachloride, petroleum ether | HSDB | ||
| In water, 35 mg/L at 17 °C | at 17 °C | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
08 · Handling and storage
Papaverine storage and handling
Papaverine storage conditions
Papaverine hydrochloride preparations should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the injection should be avoided. ...
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Papaverine in the storage compatibility matrix →
09 · Questions
Papaverine — frequently asked questions
What is the CAS number of Papaverine?
The CAS number of Papaverine is 58-74-2. Its EC number is 200-397-2.
What is the chemical formula of Papaverine?
The molecular formula of Papaverine is C20H21NO4 and its molecular weight is 339.4 g/mol.
What does a Papaverine label have to show?
Under CLP Annex VI the label for Papaverine carries the pictogram Exclamation mark and the signal word is Warning.
Is Papaverine flammable?
CLP Annex VI assigns Papaverine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Papaverine a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Papaverine. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Papaverine?
The boiling point reported for Papaverine is 135 °C (275 °F), sublimes (HSDB).
What is the melting point of Papaverine?
The melting point reported for Papaverine is 147.5 °C (297.5 °F) (HSDB).
How should Papaverine be stored?
Papaverine hydrochloride preparations should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the injection should be avoided. ... (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Papaverine
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