Substance profile
Sodium Fluoride
Sodium Fluoride is colorless, cubic or tetragonal crystals and is odorless.
01 · Identification
What Sodium Fluoride is
Sodium Fluoride is colorless, cubic or tetragonal crystals and is odorless. Its molecular formula is FNa and its molecular weight is 41.988 g/mol. It boils at 1704 °C, melts at 993 °C, is practically insoluble in water.
Under the GHS it carries the signal word Danger. It is classed as teratogens.
02 · Identifiers
Sodium Fluoride identifiers and molecular data
Sodium Fluoride CAS number and EC number
Sodium Fluoride molecular formula and molecular weight
03 · GHS classification
Sodium Fluoride hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Sodium Fluoride pictograms and signal word
Sodium Fluoride hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
Sodium Fluoride hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H301 | Toxic if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
Sodium Fluoride supplemental EU statements (EUH)
| Code | Statement |
|---|---|
| EUH032 | Contact with acids liberates very toxic gas. |
This page lists only the codes assigned to Sodium Fluoride. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Sodium Fluoride
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Sodium Fluoride issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Sodium Fluoride precautionary statements
CLP Annex VI assigns 13 precautionary statements to Sodium Fluoride. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Sodium Fluoride name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | натриев флуорид |
| Spanish español | Fluoruro de sodio |
| Czech čeština | fluorid sodný |
| Danish dansk | natriumfluorid |
| German Deutsch | Natriumfluorid |
| Estonian eesti | naatriumfluoriid |
| Greek ελληνικά | φθοριούχο νάτριο |
| English English | sodium fluoride |
| French français | fluorure de sodium |
| Croatian hrvatski | natrijev fluorid |
| Italian italiano | fluoruro di sodio |
| Latvian latviešu | nātrija fluorīds |
| Lithuanian lietuvių | natrio fluoridas |
| Hungarian magyar | nátrium-fluorid |
| Maltese Malti | fluworur tas-sodju |
| Dutch Nederlands | natriumfluoride |
| Polish polski | fluorek sodu |
| Portuguese português | fluoreto de sódio |
| Romanian română | fluorură de sodiu |
| Slovak slovenčina | fluorid sodný |
| Slovenian slovenščina | natrijev fluorid |
| Finnish suomi | natriumfluoridi |
| Swedish svenska | natriumfluorid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Sodium Fluoride GHS label elements
Everything CLP Annex VI fixes for Sodium Fluoride, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Sodium Fluoride
- Toxic if swallowed.
- Causes skin irritation.
- Causes serious eye irritation.
- Contact with acids liberates very toxic gas.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Sodium Fluoride in the GHS label constructor →
07 · Health hazards
Sodium Fluoride health hazards and exposure limits
Sodium Fluoride hazard summary
A skin, eye, and respiratory tract irritant; May cause fluorosis; [ICSC] The PEL and IDLH apply to sodium fluoride and other inorganic, solid fluorides. [NIOSH] Abnormal liver enzymes have been reported in cases of sodium fluoride toxicity. [HSDB] See FLUORIDES.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Sodium Fluoride carcinogenicity classification
Under the conditions of these 2-year dosed water studies, there was equivocal evidence of carcinogenic activity of sodium fluoride in male F344/N rats, based on the occurrence of a small number of osteosarcomas in dosed animals. "Equivocal evidence" is a category for uncertain findings defined as studies that are interpreted as showing a marginal increase of neoplasms that may be related to chemical administration. There was no evidence of carcinogenic activity in female F344/N rats receiving sodium fluoride at concentrations of 25, 100, or 175 ppm (11, 45, or 79 ppm fluoride) in drinking water for 2 years. There was no evidence of carcinogenic activity of sodium fluoride in male or female mice receiving sodium fluoride at concentrations of 25, 100, or 175 ppm in drinking water for 2 years.
Source: US National Toxicology Program · TR-393: Toxicology and Carcinogenesis Studies of Sodium Fluoride (CASRN 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (1990 )
The IARC Working Group concluded that sodium fluoride (Group 3) are not classifiable as to their carcinogenicity to humans. /Sodium fluoride was reviewed by the IARC Working Group. Data for it are published in the IARC Monograph on sodium fluoride. No evaluation of the carcinogenicity for sodium fluoride is given; Fluorides (inorganic, used in drinking-water/
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Sodium Fluoride occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 2.5 [mg/m3], as F | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | TWA 2.5 mg/m3 [*Note: The PEL also applies to other inorganic, solid fluorides (as F).] | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | TWA 2.5 mg/m3 [*Note: The REL also applies to other inorganic, solid fluorides (as F).] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 250 mg F/m3 (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 250 mg/cu m (as F) | Hazardous Substances Data Bank (HSDB) |
| IDLH | 250 mg/m3 (as F) | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Sodium Fluoride properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Sodium Fluoride boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 1704 °C (3099.2 °F) | HSDB | |
| 1704 °C (3099 °F) | NIOSH | ||
| 1695 °C (3083 °F) | at 760 mmHg | CAMEO |
Sodium Fluoride melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 993 °C (1819.4 °F) | HSDB | |
| 992.78 °C (1819 °F) | NIOSH |
Sodium Fluoride density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 2.78 g/cm³ | HSDB | |
| 2.79 g/cm³ | at 20 °C | CAMEO |
Sodium Fluoride solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Insoluble in alcohol | HSDB | |
| 4% | NIOSH | ||
| 10 to 50 mg/mL at 73 °F (NTP, 1992) | at 22.78 °C | CAMEO |
Sodium Fluoride vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0 mmHg | approx | NIOSH |
| 1 mmHg | at 1077 °C | HSDB | |
| 1 mmHg | at 1077.22 °C | CAMEO |
Sodium Fluoride autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | Not flammable (USCG, 1999) | CAMEO |
Sodium Fluoride lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Noncombustible Solid | NIOSH |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Sodium Fluoride fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Sodium Fluoride fire potential
Not combustible.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Sodium Fluoride storage and handling
Sodium Fluoride safe storage
Separated from acids and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Sodium Fluoride storage conditions
Aqueous solutions of sodium fluoride slowly decompose and become alkaline when stored in glass. Therefore, sodium fluoride solutions should be stored in tight, plastic containers, especially if the pH of the solution is less than 7.5. Sodium fluoride solutions and tablets should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the solutions should be avoided. Sodium fluoride is incompatible with calcium and magnesium salts.
Source: Hazardous Substances Data Bank (HSDB)
Sodium Fluoride incompatible materials
Strong oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
Sodium Fluoride reactivity
SODIUM FLUORIDE reacts with acids to form corrosive and toxic HF [Handling Chemicals Safely 1980 p. 842].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Sodium Fluoride in the storage compatibility matrix →
11 · Transport
Sodium Fluoride UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
The same CAS number is shipped under more than one UN number. Which entry applies follows from the form and the concentration of the consignment — read the proper shipping name, not the CAS.
Sodium Fluoride under UN 1690 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| SODIUM FLUORIDE, SOLID | 6.1 | T5 | III | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 6.1 is “Toxic substances” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Sodium fluoride, solid | 6.1 | III | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 6.1 is “Poisonous materials” (49 CFR 173.2).
Sodium Fluoride under UN 3415 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| SODIUM FLUORIDE SOLUTION | 6.1 | T4 | III | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 6.1 is “Toxic substances” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Sodium fluoride solution | 6.1 | III | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 6.1 is “Poisonous materials” (49 CFR 173.2).
12 · Questions
Sodium Fluoride — frequently asked questions
What is the CAS number of Sodium Fluoride?
The CAS number of Sodium Fluoride is 7681-49-4. Its EC number is 231-667-8.
What is the chemical formula of Sodium Fluoride?
The molecular formula of Sodium Fluoride is FNa and its molecular weight is 41.988 g/mol.
What does a Sodium Fluoride label have to show?
Under CLP Annex VI the label for Sodium Fluoride carries the pictogram Skull and crossbones and the signal word is Danger.
Is Sodium Fluoride flammable?
CLP Annex VI assigns Sodium Fluoride no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Sodium Fluoride a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Sodium Fluoride. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for Sodium Fluoride?
The US occupational exposure limit reported for Sodium Fluoride is 2.5 [mg/m3], as F (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Sodium Fluoride?
The boiling point reported for Sodium Fluoride is 1704 °C (3099.2 °F) (HSDB).
What is the melting point of Sodium Fluoride?
The melting point reported for Sodium Fluoride is 993 °C (1819.4 °F) (HSDB).
How should Sodium Fluoride be stored?
Aqueous solutions of sodium fluoride slowly decompose and become alkaline when stored in glass. Therefore, sodium fluoride solutions should be stored in tight, plastic containers, especially if the pH of the solution is less than 7.5. Sodium fluoride solutions and tablets should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the solutions should be avoided. Sodium fluoride is incompatible with calcium and magnesium salts. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Sodium Fluoride
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