Safety data sheet reference · CAS 13463-67-7
Titanium dioxide SDS
also: titanium dioxide MSDS · safety data sheet · TiO2 · CAS 13463-67-7 · EC 236-675-5 · titania
Official PDF from supplier
This page is a reference, not the legal document.
CAS number
13463-67-7
EC number
236-675-5
CLP Annex VI index
022-006-00-2
Molecular formula
O2Ti
Structural formula
TiO2
Molar mass
79.866 g/mol
§ 02 · Hazards identification
Titanium dioxide harmonised EU classification
CLP Annex VI · Index 022-006-00-2. A supplier SDS may add self-classified hazards — this is the legal minimum.
Precautionary statements
Codes ending in a colon introduce the action that follows — on a label they are printed as combined statements, such as P305+P351+P338.
§ 03 · Composition and identifiers
Titanium dioxide structure
Titanium dioxide is not a molecular compound. In the solid its atoms form an extended lattice, so TiO2 is a formula unit — the ratio of atoms — and not a molecule. There is no skeletal formula to draw.
Identifiers from PubChem (NIH, public domain).
§ 04 · First-aid measures
Titanium dioxide first aid measures
Call your national emergency number first. These are published first-aid measures, not medical advice, and they do not replace emergency services, a poison control centre or the supplier's safety data sheet.
§4–§6 below reproduce the CAMEO Chemicals entry TITANIUM DIOXIDE. CAMEO publishes response data per product entry, so the entry can describe a solution, a refrigerated liquid or a molten form rather than the pure substance in §9 — check it matches what you are handling.
EYES
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
Source: NTP, 1992 — via CAMEO Chemicals (NOAA), public domain.
§ 05 · Fire-fighting measures
Titanium dioxide fire fighting measures
Fire and explosion hazard
Literature sources indicate that this chemical is noncombustible.
Extinguishing media and tactics
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Source: NTP, 1992 — via CAMEO Chemicals (NOAA), public domain. Entry: TITANIUM DIOXIDE.
§ 06 · Accidental release measures
Titanium dioxide spill and leak response
Containment and clean-up
SMALL SPILLS AND LEAKAGEIf you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONSYou should store this material under ambient temperatures.
Source: NTP, 1992 — via CAMEO Chemicals (NOAA), public domain. Entry: TITANIUM DIOXIDE.
§ 07 · Handling and storage
Titanium dioxide computed storage compatibility
Derived from CLP Annex VI classification and CAMEO reactive-group data — not copied from a PDF.
Full interactive verdict — reactions, gas release on contact, ADR forms →
§ 08 · Exposure controls
Titanium dioxide exposure limits (IDLH)
IDLH
Immediately Dangerous to Life or Health
5,000 mg/m3
Carcinogen
NIOSH lists titanium dioxide as a potential occupational carcinogen — exposure should be kept as low as achievable regardless of the IDLH figure.
NIOSH Pocket Guide — Titanium dioxide →
IDLH from the NIOSH Pocket Guide to Chemical Hazards (CDC, U.S. public domain), via CAMEO Chemicals. Occupational exposure limits — OSHA PEL, NIOSH REL and EU IOELV — are not published on this page yet.
§ 09 · Physical and chemical properties
Titanium dioxide physical properties
Source: CAMEO Chemicals (NOAA, public domain); per-value source references stored in the database.
§ 10 · Stability and reactivity
Reactive group (CAMEO/NOAA): Non-Redox-Active Inorganic Compounds. Our database documents 12 incompatible and 19 caution reaction-partner groups for titanium dioxide — including which combinations release gas on contact. See the per-partner breakdown with gas release →
12
Incompatible
19
Caution
§ 11 · Toxicological information
Titanium dioxide acute toxicity estimates
| Route | ATE value |
|---|---|
| Oral (mg/kg bw) | 14 |
| Dermal (mg/kg bw) | No data |
| Inhalation, gas (ppmV, 4 h) | No data |
| Inhalation, vapour (mg/L, 4 h) | No data |
| Inhalation, dust / mist (mg/L, 4 h) | No data |
Acute Toxicity Estimates (ATE) are regulatory values used for classification under CLP and OSHA HCS Appendix A — not a measure of "safe dose". Empty routes render as "No data", never as a numeric zero.
§ 13 · Disposal considerations
Dispose of waste and residues in accordance with local and national regulations — in the EU under the Waste Framework Directive 2008/98/EC. Never discharge to drains or municipal waste; hand contaminated packaging and unused product to an authorised waste-disposal company. The supplier's SDS section 13 lists the applicable waste codes for the specific product.
MSDS vs SDS
Titanium dioxide MSDS vs SDS: is there a difference?
MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the format is set by REACH Annex II. So a "titanium dioxide MSDS" and a "titanium dioxide SDS" refer to the same document — today it is issued as an SDS. Full breakdown of the differences →
Substance profile
What titanium dioxide is
Physical and chemical properties with the conditions each value was measured under, synonyms, formula and the harmonised CLP classification →
Compliance hub
From classification to SDS
The classification above corresponds to Section 2 of a Safety Data Sheet. Learn how a compliant 16-section SDS is structured and authored →
GHS label maker
Build the label for titanium dioxide
Pictograms, signal word and H-statements combined into a compliant label layout →
§ 16 · Sources
- Classification: Regulation (EC) No 1272/2008 (CLP), Annex VI
- Transport: UN ADR 2025 (UNECE), Table A
- Reactivity: NOAA CAMEO Chemicals reactive-group matrix (public domain)
- Physical properties: CAMEO Chemicals (NOAA, public domain) — per-value source references stored in the database
- Emergency response (§4–§6): ERG 2024 (PHMSA) · NIOSH Pocket Guide (CDC) · CHRIS (USCG) · NTP · EPA — via CAMEO Chemicals (NOAA), all US federal public domain, reproduced verbatim
- Substance data: PubChem · ECHA
Reference aid only. This page summarises the harmonised EU classification and computed storage guidance — it is not a Safety Data Sheet and does not replace one. Always verify hazards, handling and storage against the supplier's SDS (sections 7 and 10) and local regulations before use. Page updated 2026-08-11.
Frequently asked questions about titanium dioxide
Is an MSDS the same as an SDS?
In practice, yes. MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the SDS format is set by REACH Annex II. A document you find labelled "titanium dioxide MSDS" is today issued as an SDS.
What GHS pictograms does titanium dioxide require?
Under the harmonised EU classification (CLP Annex VI), titanium dioxide carries GHS08 with the signal word "Warning". Hazard statements: H351. A supplier's SDS may add self-classified hazards on top of this harmonised minimum.
Where can I download an official titanium dioxide SDS PDF?
From your own supplier — an SDS is issued per product and supplier, so the correct PDF for an inspection is the one matching the product you actually purchased. The supplier links on this page lead to the official SDS libraries of major distributors.
Call emergency services first
112 in the EU · 911 in the US. This screen is published response information, not medical advice, and it does not replace emergency services, a poison centre or the supplier's safety data sheet.
Text below is the CAMEO Chemicals entry TITANIUM DIOXIDE — confirm it matches the form in front of you.
01 · First aid
What to do for the person
EYES
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
02 · Fire
Extinguishing and tactics
Fire and explosion hazard
Literature sources indicate that this chemical is noncombustible.
Extinguishing media and tactics
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
03 · Spill
Containment, isolation, evacuation
Containment and clean-up
SMALL SPILLS AND LEAKAGEIf you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONSYou should store this material under ambient temperatures.
Sources: ERG 2024 (PHMSA) · NIOSH Pocket Guide (CDC) · CHRIS (USCG) · NTP · EPA — via CAMEO Chemicals (NOAA), public domain. Text reproduced verbatim.