Substance profile
Titanium dioxide
Titanium dioxide is white, tetragonal crystals and is odorless.
01 · Identification
What Titanium dioxide is
Titanium dioxide is white, tetragonal crystals and is odorless. Its molecular formula is O2Ti and its molecular weight is 79.866 g/mol. It boils at 2500 °C, melts at 1855 °C, is practically insoluble in water.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Titanium dioxide identifiers and molecular data
Titanium dioxide CAS number and EC number
Titanium dioxide molecular formula and molecular weight
Other names for Titanium dioxide
- titania
- TiO2
- A 100
- A 200
- A 200 (Pigment)
- A-Fil Cream
- A-Fn 3
- Aerosil P 25
- Aerosil P 25S6
- Aerosil P 27
- Aerosil T 805
- Af-E 3D
- Ak 15
- Ak 15 (Pigment)
- [in powder form containing 1 % or more of particles with aerodynamic diameter ≤ 10 μm]
03 · GHS classification
Titanium dioxide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Titanium dioxide pictograms and signal word
Titanium dioxide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
Titanium dioxide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
This page lists only the codes assigned to Titanium dioxide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Titanium dioxide
Our own Titanium dioxide safety data sheet walks through all sixteen sections of the published data. What it is not is the document an inspector asks for: an SDS is issued for a product by its supplier, so the sheet covering the grade actually standing in your store exists only in that supplier’s version. Collecting those and keeping them current as suppliers revise them is a separate job.
04 · Precautionary statements
Titanium dioxide precautionary statements
CLP Annex VI assigns 4 precautionary statements to Titanium dioxide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Titanium dioxide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | титанов диоксид |
| Spanish español | Dióxido de titanio |
| Czech čeština | oxid titaničitý |
| Danish dansk | titandioxid |
| German Deutsch | Titandioxid |
| Estonian eesti | titaandioksiid |
| Greek ελληνικά | διοξείδιο του τιτανίου |
| English English | titanium dioxide |
| French français | dioxyde de titane |
| Croatian hrvatski | titanijev dioksid |
| Italian italiano | biossido di titanio |
| Latvian latviešu | titāna dioksīds |
| Lithuanian lietuvių | titano dioksidas |
| Hungarian magyar | titán-dioxid |
| Maltese Malti | diossidu tat-titanju |
| Dutch Nederlands | titaniumdioxide |
| Polish polski | ditlenek tytanu |
| Portuguese português | dióxido de titânio |
| Romanian română | dioxid de titan |
| Slovak slovenčina | oxid titaničitý |
| Slovenian slovenščina | titanov dioksid |
| Finnish suomi | Titaanidioksidi |
| Swedish svenska | titandioxid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Titanium dioxide GHS label elements
Everything CLP Annex VI fixes for Titanium dioxide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Titanium dioxide
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Obtain special instructions before use.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Titanium dioxide in the GHS label constructor →
07 · Health hazards
Titanium dioxide health hazards and exposure limits
Titanium dioxide hazard summary
Not a skin irritant; [IUCLID] NIOSH has determined that ultrafine TiO2 is a potential occupational carcinogen but that there are insufficient data at this time to classify fine TiO2 as a potential occupational carcinogen. Summary of Epidemiologic Studies: Overall, these studies provide no clear evidence of elevated risks of lung cancer mortality or morbidity among those workers exposed to TiO2 dust. [Reference #1] A skin and strong eye irritant; Toxic by inhalation; [Sigma-Aldrich MSDS] See Titanium dioxide.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Titanium dioxide carcinogenicity classification
Studied by the US National Toxicology Program: TR-097: Bioassay of Titanium Dioxide for Possible Carcinogenicity (CASRN 13463-67-7) (1979 )
Cancer in humans: There is inadequate evidence in humans for the carcinogenicity of titanium dioxide. Cancer in experimental animals: There is sufficient evidence in experimental animals for the carcinogenicity of titanium dioxide. Overall evaluation: Titanium dioxide is possibly carcinogenic to humans (Group 2B).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Titanium dioxide occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 15.0 [mg/m3], total dust | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 15 mg/m³ (total dust) | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 15 mg/m3 See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | Ca See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 5000 mg/m3 ; A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 5000.0 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 5000 mg/cu m; NIOSH considers titanium dioxide to be a potential occupational carcinogen. | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Titanium dioxide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Titanium dioxide boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 2500 °C (4532 °F) | HSDB | |
| 2500 °C (4532 °F) | at 760 mmHg | CAMEO |
Titanium dioxide melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 1855 °C (3371 °F) | HSDB |
Titanium dioxide density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 4.23 g/cm³ | HSDB | |
| 4.17 g/cm³ | HSDB | ||
| 4.26 g/cm³ | NIOSH |
Titanium dioxide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Insoluble in water | HSDB | |
| Soluble in hot concentrated sulfuric acid; in hydrofluoric acid; insoluble in hydrochloric acid, nitric acid or diluted sulfuric acid | HSDB | ||
| INSOL IN ORG SOLVENTS | HSDB |
Titanium dioxide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0 mmHg | approx | NIOSH |
| 0 mmHg | at 20 °C | CAMEO |
Titanium dioxide lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Noncombustible Solid | NIOSH |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Titanium dioxide fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Titanium dioxide fire potential
Noncombustible
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Titanium dioxide storage and handling
Titanium dioxide reactive group
CAMEO Chemicals places Titanium dioxide in the reactive group Non-Redox-Active Inorganic Compounds. Compatibility with other chemicals is worked out from the group, not from the individual substance — which is why two substances you have never seen react can still be flagged as a pair that must be separated.
A reactive group is a CAMEO Chemicals (US NOAA) grouping, not a GHS hazard class: it has no code, no category and no legal force. It is what the storage compatibility matrix on this site computes from.
Titanium dioxide safe storage
Store in covered containers.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Titanium dioxide incompatible materials
The reaction of lithium and titanium dioxide occurs around 200 °C with a flash of light; the temperature can reach 900 °C.
Source: Hazardous Substances Data Bank (HSDB)
Titanium dioxide reactivity
TITANIUM DIOXIDE is incompatible with strong oxidizers and strong acids. Violent or incandescent reactions may occur with metals (e.g. aluminum, calcium, magnesium, potassium, sodium, zinc and lithium). (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Titanium dioxide in the storage compatibility matrix →
11 · Questions
Titanium dioxide — frequently asked questions
What is the CAS number of Titanium dioxide?
The CAS number of Titanium dioxide is 13463-67-7. Its EC number is 236-675-5.
What is the chemical formula of Titanium dioxide?
The molecular formula of Titanium dioxide is O2Ti and its molecular weight is 79.866 g/mol.
What does a Titanium dioxide label have to show?
Under CLP Annex VI the label for Titanium dioxide carries the pictogram Health hazard and the signal word is Warning.
Is Titanium dioxide flammable?
CLP Annex VI assigns Titanium dioxide no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Titanium dioxide a carcinogen?
CLP Annex VI assigns Titanium dioxide H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for Titanium dioxide?
The US occupational exposure limit reported for Titanium dioxide is 15.0 [mg/m3], total dust (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Titanium dioxide?
The boiling point reported for Titanium dioxide is 2500 °C (4532 °F) (HSDB).
What is the melting point of Titanium dioxide?
The melting point reported for Titanium dioxide is 1855 °C (3371 °F) (HSDB).
Nearby
Substances next to Titanium dioxide
Keep going: substances starting with T, or search the whole database by name, CAS number, pictogram or signal word.
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