Safety data sheet reference · CAS 584-84-9
Toluene diisocyanate SDS
also: toluene diisocyanate MSDS · safety data sheet · CH3C6H3(NCO)2 · CAS 584-84-9 · EC 202-039-0 · TDI
Official PDF from supplier
This page is a reference, not the legal document.
CAS number
584-84-9
EC number
202-039-0
CLP Annex VI index
615-006-00-4
Molecular formula
CH3C6H3(NCO)2
§ 02 · Hazards identification
Toluene diisocyanate harmonised EU classification
CLP Annex VI · Index 615-006-00-4. A supplier SDS may add self-classified hazards — this is the legal minimum.
Precautionary statements
Codes ending in a colon introduce the action that follows — on a label they are printed as combined statements, such as P305+P351+P338.
§ 03 · Composition and identifiers
Toluene diisocyanate molecular structure
Toluene diisocyanate is a molecular compound. The skeletal formula below is drawn from its PubChem SMILES string, and every value in this section is computed from that structure.
2D skeletal formula · CH3C6H3(NCO)2
Functional groups
aromatic ring, isocyanate
Electron count
64 valence e⁻ · 6 lone pairs
Identifiers from PubChem (NIH, public domain). Structure diagram drawn with RDKit from the SMILES string. Geometry and hybridisation are computed from the connection table, not measured.
§ 04 · First-aid measures
Toluene diisocyanate first aid measures
Call your national emergency number first. These are published first-aid measures, not medical advice, and they do not replace emergency services, a poison control centre or the supplier's safety data sheet.
§4–§6 below reproduce the CAMEO Chemicals entry TOLUENE-2,4-DIISOCYANATE. CAMEO publishes response data per product entry, so the entry can describe a solution, a refrigerated liquid or a molten form rather than the pure substance in §9 — check it matches what you are handling.
Signs and Symptoms of Acute Toluene 2,4-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,4-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Cough, laryngitis, chest pain, tightness of the chest, bronchitis, asthma, emphysema, and enlargement of the right side of the heart may also occur. Gastrointestinal effects may include vomiting, diarrhea, and abdominal pain. Headache, insomnia, euphoria, depression, anxiety, paranoia, neuroses, and ataxia (incoordination) may also be noted.
Emergency Life-Support Procedures: Acute exposure to toluene 2,4-diisocyanate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to toluene 2,4-diisocyanate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility.
Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to toluene 2,4-diisocyanate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility.
Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 7. RUSH to a health care facility.
Source: EPA, 1998 — via CAMEO Chemicals (NOAA), public domain.
§ 05 · Fire-fighting measures
Toluene diisocyanate fire fighting measures
ERG 2024 · GUIDE 156 Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)ERG guidance is written per response guide, not per substance — Guide 156 covers every material assigned to it, so a few sentences reference other UN numbers in the same group.
Fire and explosion hazard
When heated to decomposition it emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F.
Extinguishing media and tactics
If water gets below the surface of the liquid, it will turn to steam and cause frothing. Full protective clothing, including self-contained breathing apparatus, rubber gloves, boots and bands around legs, arms, and waist should be provided. No skin surface should be exposed.
Move container from fire area if you can do it without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. Dike fire control water for later disposal; do not scatter the material.
Water gently applied to surface or foam may cause frothing which will extinguish the fire.
If material is on fire or involved in fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. Use water spray to absorb vapor.
Source: EPA, 1998 — via CAMEO Chemicals (NOAA), public domain. Entry: TOLUENE-2,4-DIISOCYANATE.
§ 06 · Accidental release measures
Toluene diisocyanate spill and leak response
Containment and clean-up
Caution : Mixing with water may result in a violent reaction. Sources of extreme heat or ignition including sparks or fire may result in formation of toxic nitrogen oxide gases.
Shut off ignition sources; no smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other non-combustible absorbent material and place into containers for later disposal.
Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area.
Large spills: dike far ahead of spill for later disposal. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. If material is not on fire and not involved in fire; keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary; attempt to stop leak if without hazard. Use water spray to knock down vapors. If material is leaking (not on fire), downwind evacuation must be considered.
Initial isolation and evacuation
IMMEDIATE PRECAUTIONARY MEASUREIsolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILLIncrease the immediate precautionary measure distance, in the downwind direction, as necessary.
FIREIf tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Source: EPA, 1998 — via CAMEO Chemicals (NOAA), public domain. Entry: TOLUENE-2,4-DIISOCYANATE.
§ 07 · Handling and storage
Toluene diisocyanate computed storage compatibility
Derived from CLP Annex VI classification and CAMEO reactive-group data — not copied from a PDF.
↔ Keep separate
Full interactive verdict — reactions, gas release on contact, ADR forms →
§ 08 · Exposure controls
Toluene diisocyanate exposure limits (IDLH)
IDLH
Immediately Dangerous to Life or Health
2.5 ppm
Carcinogen
NIOSH lists toluene diisocyanate as a potential occupational carcinogen — exposure should be kept as low as achievable regardless of the IDLH figure.
NIOSH Pocket Guide — Toluene diisocyanate →
IDLH from the NIOSH Pocket Guide to Chemical Hazards (CDC, U.S. public domain), via CAMEO Chemicals. Occupational exposure limits — OSHA PEL, NIOSH REL and EU IOELV — are not published on this page yet.
§ 09 · Physical and chemical properties
Toluene diisocyanate physical properties
Fire-relevant values first — flash point and explosion limits decide the storage and ventilation regime.
Flash point
132.2 °C
Explosion limits
0.9 – 9.5 %
LEL / UEL in air, vol.
Source: CAMEO Chemicals (NOAA, public domain); per-value source references stored in the database.
§ 10 · Stability and reactivity
Reactive group (CAMEO/NOAA): Isocyanates and Isothiocyanates, Polymerizable Compounds. Our database documents 61 incompatible and 55 caution reaction-partner groups for toluene diisocyanate — including which combinations release gas on contact. See the per-partner breakdown with gas release →
61
Incompatible
55
Caution
§ 13 · Disposal considerations
Dispose of waste and residues in accordance with local and national regulations — in the EU under the Waste Framework Directive 2008/98/EC. Never discharge to drains or municipal waste; hand contaminated packaging and unused product to an authorised waste-disposal company. The supplier's SDS section 13 lists the applicable waste codes for the specific product.
§ 14 · Transport information
Toluene diisocyanate road transport — ADR 2025
UN number
Proper shipping name
TOLUENE DIISOCYANATE
Class · PG
6.1 · II
Classification code
T1
Transport category
2
ADR labels
6.1
Hazard ID (Kemler) / UN plate
Top: hazard identification number (Kemler). Bottom: UN number — as carried on the orange plate of the transport unit.
Source: UN ADR 2025 (ECE/TRANS/352), Table A. Road (ADR) only — for sea (IMDG) and air (IATA), consult the supplier's SDS §14.
MSDS vs SDS
Toluene diisocyanate MSDS vs SDS: is there a difference?
MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the format is set by REACH Annex II. So a "toluene diisocyanate MSDS" and a "toluene diisocyanate SDS" refer to the same document — today it is issued as an SDS. Full breakdown of the differences →
Other acute toxics in our database
- (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, rotenone 83-79-4
- (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile 61826-76-4
- (4-ammonio-m-tolyl)ethyl(2-hydroxyethyl)ammonium sulphate 25646-77-9
- (Methoxyethyl)mercury chloride 123-88-6
- (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole 86347-14-0
- [(dimethylsilylene)bis((1,2,3,3a,7a-η)-1H-inden-1-ylidene)dimethyl]hafnium 137390-08-0
- 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine hydrochloride 70918-74-0
- 1-(3,4-dichlorophenylimino) thiosemicarbazide 5836-73-7
Compliance hub
From classification to SDS
The classification above corresponds to Section 2 of a Safety Data Sheet. Learn how a compliant 16-section SDS is structured and authored →
GHS label maker
Build the label for toluene diisocyanate
Pictograms, signal word and H-statements combined into a compliant label layout →
§ 16 · Sources
- Classification: Regulation (EC) No 1272/2008 (CLP), Annex VI
- Transport: UN ADR 2025 (UNECE), Table A
- Reactivity: NOAA CAMEO Chemicals reactive-group matrix (public domain)
- Physical properties: CAMEO Chemicals (NOAA, public domain) — per-value source references stored in the database
- Emergency response (§4–§6): ERG 2024 (PHMSA) · NIOSH Pocket Guide (CDC) · CHRIS (USCG) · NTP · EPA — via CAMEO Chemicals (NOAA), all US federal public domain, reproduced verbatim
- Substance data: PubChem · ECHA
Reference aid only. This page summarises the harmonised EU classification and computed storage guidance — it is not a Safety Data Sheet and does not replace one. Always verify hazards, handling and storage against the supplier's SDS (sections 7 and 10) and local regulations before use. Page updated 2026-08-11.
Frequently asked questions about toluene diisocyanate
Is an MSDS the same as an SDS?
In practice, yes. MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the SDS format is set by REACH Annex II. A document you find labelled "toluene diisocyanate MSDS" is today issued as an SDS.
What GHS pictograms does toluene diisocyanate require?
Under the harmonised EU classification (CLP Annex VI), toluene diisocyanate carries GHS06 and GHS08 with the signal word "Danger". Hazard statements: H351, H330, H335, H315, H319, H334, H317, H412. A supplier's SDS may add self-classified hazards on top of this harmonised minimum.
Where can I download an official toluene diisocyanate SDS PDF?
From your own supplier — an SDS is issued per product and supplier, so the correct PDF for an inspection is the one matching the product you actually purchased. The supplier links on this page lead to the official SDS libraries of major distributors.
Call emergency services first
112 in the EU · 911 in the US. This screen is published response information, not medical advice, and it does not replace emergency services, a poison centre or the supplier's safety data sheet.
Text below is the CAMEO Chemicals entry TOLUENE-2,4-DIISOCYANATE — confirm it matches the form in front of you.
01 · First aid
What to do for the person
Signs and Symptoms of Acute Toluene 2,4-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,4-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Cough, laryngitis, chest pain, tightness of the chest, bronchitis, asthma, emphysema, and enlargement of the right side of the heart may also occur. Gastrointestinal effects may include vomiting, diarrhea, and abdominal pain. Headache, insomnia, euphoria, depression, anxiety, paranoia, neuroses, and ataxia (incoordination) may also be noted.
Emergency Life-Support Procedures: Acute exposure to toluene 2,4-diisocyanate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to toluene 2,4-diisocyanate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility.
Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to toluene 2,4-diisocyanate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility.
Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 7. RUSH to a health care facility.
02 · Fire
Extinguishing and tactics
Fire and explosion hazard
When heated to decomposition it emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F.
Extinguishing media and tactics
If water gets below the surface of the liquid, it will turn to steam and cause frothing. Full protective clothing, including self-contained breathing apparatus, rubber gloves, boots and bands around legs, arms, and waist should be provided. No skin surface should be exposed.
Move container from fire area if you can do it without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. Dike fire control water for later disposal; do not scatter the material.
Water gently applied to surface or foam may cause frothing which will extinguish the fire.
If material is on fire or involved in fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. Use water spray to absorb vapor.
03 · Spill
Containment, isolation, evacuation
Containment and clean-up
Caution : Mixing with water may result in a violent reaction. Sources of extreme heat or ignition including sparks or fire may result in formation of toxic nitrogen oxide gases.
Shut off ignition sources; no smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other non-combustible absorbent material and place into containers for later disposal.
Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area.
Large spills: dike far ahead of spill for later disposal. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. If material is not on fire and not involved in fire; keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary; attempt to stop leak if without hazard. Use water spray to knock down vapors. If material is leaking (not on fire), downwind evacuation must be considered.
Initial isolation and evacuation
IMMEDIATE PRECAUTIONARY MEASUREIsolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILLIncrease the immediate precautionary measure distance, in the downwind direction, as necessary.
FIREIf tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Sources: ERG 2024 (PHMSA) · NIOSH Pocket Guide (CDC) · CHRIS (USCG) · NTP · EPA — via CAMEO Chemicals (NOAA), public domain. Text reproduced verbatim.