Health hazard · Specific target organ toxicity - single exposure
H335 — May cause respiratory irritation
Health hazard statements describe what the substance does to a person exposed to it. 230 substances with a harmonised EU classification carry this code.
EU CLP: currentUS OSHA HazCom: currentUS HazCom 2012: currentUN GHS: current
01 · Wording
What H335 says
Official
May cause respiratory irritation.
Source
CLP Annex III · Health hazards
Classification 
Specific target organ toxicity - single exposure GHS chapter 3.8
Category 3 · pictogram GHS07 (exclamation mark) · signal word Warning
UN GHS history
Unchanged since 2009.
Rev.3 2009
Rev.4 2011
Rev.5 2013
Rev.6 2015
Rev.7 2017
Rev.8 2019
Rev.9 2021
Rev.10 2023
Rev.11 2025
wording never changed
Present in every UN GHS edition from Rev.3 (2009) to Rev.11 (2025), with the same wording throughout.
Nine editions of the UN model text, 86 hazard statements, 19 of which ever moved. Read the full story in what changed in UN GHS Rev.11.
02 · Languages
H335 in the 24 official EU languages
A label put on the market in an EU country must carry the wording of that country's own language version of CLP — not a translation of the English one. These 24 lines are quoted from the consolidated regulation, Annex III, and are the text to print.
| Language | Official wording of H335 |
|---|---|
| BG български Bulgarian | Може да предизвика дразнене на дихателните пътища. |
| ES español Spanish | Puede irritar las vías respiratorias. |
| CS čeština Czech | Může způsobit podráždění dýchacích cest. |
| DA dansk Danish | Kan forårsage irritation af luftvejene. |
| DE Deutsch German | Kann die Atemwege reizen. |
| ET eesti Estonian | Võib põhjustada hingamisteede ärritust. |
| EL ελληνικά Greek | Μπορεί να προκαλέσει ερεθισμό της αναπνευστικής οδού. |
| EN English English | May cause respiratory irritation. |
| FR français French | Peut irriter les voies respiratoires. |
| GA Gaeilge Irish | D'fhéadfadh sé a bheith ina chúis le greannú riospráide. |
| HR hrvatski Croatian | Može nadražiti dišni sustav. |
| IT italiano Italian | Può irritare le vie respiratorie. |
| LV latviešu Latvian | Var izraisīt elpceļu kairinājumu. |
| LT lietuvių Lithuanian | Gali dirginti kvėpavimo takus. |
| HU magyar Hungarian | Légúti irritációt okozhat. |
| MT Malti Maltese | Jista’ jikkawża irritazzjoni respiratorja. |
| NL Nederlands Dutch | Kan irritatie van de luchtwegen veroorzaken. |
| PL polski Polish | Może powodować podrażnienie dróg oddechowych. |
| PT português Portuguese | Pode provocar irritação das vias respiratórias. |
| RO română Romanian | Poate provoca iritarea căilor respiratorii. |
| SK slovenčina Slovak | Môže spôsobiť podráždenie dýchacích ciest. |
| SL slovenščina Slovenian | Lahko povzroči draženje dihalnih poti. |
| FI suomi Finnish | Saattaa aiheuttaa hengitysteiden ärsytystä. |
| SV svenska Swedish | Kan orsaka irritation i luftvägarna. |
Source: CELEX:02008R1272-20260501, Annex III. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic. Irish is one of the 24 official languages and its H and P texts are printed inside the multilingual Annex tables, but no consolidated CLP has ever been published in Irish — which is why an Irish-primary label cannot be built here.
03 · Legal status
Where H335 is current
GHS is a United Nations model text, revised every two years, and each jurisdiction adopts a revision on its own timetable. A code can be legally current in one system and deleted in another — that is normal, not an error.
| Jurisdiction | Basis | Status of H335 |
|---|---|---|
| EU CLP | Regulation (EC) 1272/2008 CLP Annex IV, Part 2 (consolidated) | Current |
| US OSHA HazCom | 29 CFR 1910.1200 Appendix C UN GHS Rev.7 (final rule of 20 May 2024) | Current |
| US HazCom 2012 | legacy · GHS Rev.3 UN GHS Rev.3, Annex 3 | Current |
| UN GHS | Rev.11 (2025) UN GHS Rev.11, Annex 3 | Current |
Currently in force under: EU CLP, US OSHA HazCom, US HazCom 2012, UN GHS. Sources: EU CLP · US OSHA HazCom · US HazCom 2012 · UN GHS
04 · Substances
Substances carrying H335
Every entry whose harmonised CLP Annex VI classification includes this hazard statement. Substances with a reference page here open on this site; the rest open on ghssymbols.com. Of these, 12 are group entries such as “salts of picric acid” or “beryllium compounds” — Annex VI gives them no CAS number, so they are listed by Index No and have no page of their own.
- (1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)… CAS 42978-66-5
- (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8… CAS 83-79-4
- (Z)-octadec-9-enylamine CAS 112-90-3
- 1-Bromopropane CAS 106-94-5
- 1-Naphthol CAS 90-15-3
- 1-pentanol [1] 3-pentanol [2] CAS 71-41-0
- 1-Propanol, 2-methoxy-, 1-acetate CAS 70657-70-4
- 1,1-Dichloroethane CAS 75-34-3
- 1,2-Dibromoethane CAS 106-93-4
- 1,2-Dichlorobenzene CAS 95-50-1
- 1,2-Dichloroethane CAS 107-06-2
- 1,2-Epoxybutane CAS 106-88-7
- 1,2,4-Trimethylbenzene CAS 95-63-6
- 1,3-dichloropropene [1] (Z)-1,3-dichloropropene [2] CAS 542-75-6
- 1,3,5-Trioxane CAS 110-88-3
- 1,4-dioxane CAS 123-91-1
- 1,4,5,6,7,7-hexachlorobicyclo [2,2,1]hept-5-ene-2,3-dic… CAS 115-27-5
- 1,4,7,10-Tetraazacyclododecane disulfate CAS 112193-77-8
- 1,5-naphthylene diisocyanate [containing < 0.1 % (w/w)… CAS 3173-72-6
- 2-aminopropane CAS 75-31-0
- 2-Ethylhexyl acrylate CAS 103-11-7
- 2-furaldehyde CAS 98-01-1
- 2-Methoxy-1-propanol CAS 1589-47-5
- 2-Methyl-2-butanol CAS 75-85-4
- 2-methylpropan-1-ol CAS 78-83-1
- 2-methylpropan-2-ol CAS 75-65-0
- 2-Methylpyridine CAS 109-06-8
- 2-phenylpropene CAS 98-83-9
- 2,2,4-trimethylhexamethylene-1,6-di-isocyanate [1]… CAS 16938-22-0
- 2,3-Dichloropropene CAS 78-88-6
- 2,3-epoxypropan-1-ol CAS 556-52-5
- 2,3-epoxypropyl methacrylate CAS 106-91-2
- 2,3,4-Trichloro-1-butene CAS 2431-50-7
- 2,4-D (ISO) CAS 94-75-7
- 2,4-Dichloro-5-fluorobenzoyl chloride CAS 86393-34-2
- 2,4,5-T (ISO) CAS 93-76-5
- 2,5-Tetrahydrofurandimethanol CAS 104-80-3
- 2,6-dimethylheptan-4-one CAS 108-83-8
- 2,6-xylidine CAS 87-62-7
- 3-chloropropene CAS 107-05-1
- 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate CAS 4098-71-9
- 3,5,5-trimethylcyclohex-2-enone CAS 78-59-1
- 3a,4,7,7a-tetrahydro-4,7-methanoindene CAS 77-73-6
- 4-Chlorophenyl Isocyanate CAS 104-12-1
- 4-isocyanatosulphonyltoluene CAS 4083-64-1
- 4-Methyl-2-Pentanol CAS 108-11-2
- 4-Methylpyridine CAS 108-89-4
- 4,4'-methylenedi(cyclohexyl isocyanate) CAS 5124-30-1
- 5-Methyl-3-heptanone CAS 541-85-5
- 8,9-dinorborn-5-ene-2,3-dicarboxylic anhydride CAS 123748-85-6
- Acetaldehyde CAS 75-07-0
- Acetochlor CAS 34256-82-1
- Acibenzolar-S-Methyl CAS 135158-54-2
- Acrylonitrile CAS 107-13-1
- Allyl Alcohol CAS 107-18-6
- Allyl glycidyl ether CAS 106-92-3
- Alpha-Cypermethrin CAS 67375-30-8
- amines, coco alkyl CAS 61788-46-3
- Azocyclotin CAS 41083-11-8
- barium polysulphides CAS 50864-67-0
- Benomyl CAS 17804-35-2
- benzene-1,2,4-tricarboxylic acid 1,2-anhydride CAS 552-30-7
- Benzenesulfonamide, 4-methyl-N-(methylsulfonyl)- CAS 14653-91-9
- benzophenone-3,3',4,4'-tetracarboxylic dianhydride CAS 2421-28-5
- Beryllium CAS 7440-41-7
- beryllium compounds with the exception of aluminium… Index No 004-002-00-2
- Beryllium Oxide CAS 1304-56-9
- Biphenyl CAS 92-52-4
- bis(piperidinothiocarbonyl) disulphide CAS 94-37-1
- bisphenol A CAS 80-05-7
- bromelain, juice CAS 9001-00-7
- bromomethane CAS 74-83-9
- Bronopol CAS 52-51-7
- butan-1-ol CAS 71-36-3
- butan-2-ol [1] (S)-butan-2-ol [2] (R)-butan-2-ol [3]… CAS 78-92-2
- Butyl Acrylate CAS 141-32-2
- Butyl ether CAS 142-96-1
- butyl formate [1] tert-butyl formate [2] isobutyl… CAS 592-84-7
- Butyl glycidyl ether CAS 2426-08-6
- Butyl Methacrylate CAS 97-88-1
- Calcium Cyanamide CAS 156-62-7
- calcium polysulphides CAS 1344-81-6
- Calcium Sulfide CAS 20548-54-3
- camphechlor (ISO) CAS 8001-35-2
- Caprolactam CAS 105-60-2
- chlorine CAS 7782-50-5
- chlorocresol CAS 59-50-7
- Chloroprene CAS 126-99-8
- Chlorosulfonic acid CAS 7790-94-5
- Chlorothalonil CAS 1897-45-6
- chymotrypsin CAS 9004-07-3
- citric acid CAS 77-92-9
- crotonaldehyde CAS 4170-30-3
- Cumene CAS 98-82-8
- Cyclohexanol CAS 108-93-0
- Cyclohexyl acrylate CAS 3066-71-5
- cyclopentane-1,2,3,4-tetracarboxylic dianhydride CAS 6053-68-5
- Cypermethrin CAS 52315-07-8
- diammonium peroxodisulphate CAS 7727-54-0
- Dicamba CAS 1918-00-9
- dichloro-1,3,5-triazinetrione CAS 2782-57-2
- Dichlorodimethylsilane CAS 75-78-5
- Diethylcarbamoyl chloride CAS 88-10-8
- dimercury dichloride CAS 10112-91-1
- Dimethylcarbamoyl Chloride CAS 79-44-7
- Diphenylguanidine CAS 102-06-7
- dipotassium peroxodisulphate CAS 7727-21-1
- diquat dibromide [1] diquat dichloride [2]… CAS 85-00-7
- divanadium pentaoxide CAS 1314-62-1
- Endothal disodium salt CAS 129-67-9
- Endothall CAS 145-73-3
- Ethyl Acrylate CAS 140-88-5
- Ethyl cyanoacrylate CAS 7085-85-0
- Ethyl formate CAS 109-94-4
- ethyl lactate CAS 97-64-3
- Ethyl Methacrylate CAS 97-63-2
- Ethylamine CAS 75-04-7
- Ethylene glycol dimethacrylate CAS 97-90-5
- ethylene oxide CAS 75-21-8
- Fenpropidin CAS 67306-00-7
- Fentin acetate CAS 900-95-8
- fentin hydroxide (ISO) CAS 76-87-9
- Ferbam CAS 14484-64-1
- ficin CAS 9001-33-6
- Furfuryl Alcohol CAS 98-00-0
- glutaraldehyde CAS 111-30-8
- Guazatine CAS 108173-90-6
- Hexafluoropropylene CAS 116-15-4
- Hexamethylene diisocyanate CAS 822-06-0
- Hexamethylenediamine CAS 124-09-4
- Hexyl acrylate CAS 2499-95-8
- hydrobromic acid ... % Index No 035-002-01-8
- hydrochloric acid ... % Index No 017-002-01-X
- Hydrogen Bromide CAS 10035-10-6
- hydroxylamine ....% [> 55 % in aqueous solution] CAS 7803-49-8
- Isobutyl Methacrylate CAS 97-86-9
- Isooctyl acrylate CAS 29590-42-9
- isopentyl formate [1] pentyl formate [2] CAS 110-45-2
- Isopropyl chloroacetate CAS 105-48-6
- Lauryl Methacrylate CAS 142-90-5
- Maleic Acid CAS 110-16-7
- mecrilate CAS 137-05-3
- Mesitylene CAS 108-67-8
- Methyl Acrylate CAS 96-33-3
- Methyl chloroacetate CAS 96-34-4
- Methyl formate CAS 107-31-3
- Methyl iodide CAS 74-88-4
- Methyl Isocyanate CAS 624-83-9
- methyl lactate [1] methyl (±)-lactate [2] methyl… CAS 547-64-8
- methyl methacrylate CAS 80-62-6
- methylene diphenyl diisocyanate CAS 101-68-8
- Molybdenum trioxide CAS 1313-27-5
- mono-methylamine [1] di-methylamine [2]… CAS 74-89-5
- monoalkyl or monoaryl or monoalkyaryl esters of… Index No 607-134-00-4
- monoalkyl or monoaryl or monoalkylaryl esters of… Index No 607-133-00-9
- morfamquat (ISO) CAS 7411-47-4
- morfamquat dichloride [1] morfamquat sulfate [2] CAS 4636-83-3
- N-methyl-2-pyrrolidone CAS 872-50-4
- N-vinyl-2-pyrrolidone CAS 88-12-0
- Nabam CAS 142-59-6
- oleum ... % SO3 Index No 016-019-00-2
- p-benzoquinone CAS 106-51-4
- p-toluenesulphonic acid (containing a maximum of 5 %… CAS 104-15-4
- papain CAS 9001-73-4
- paraquat dichloride CAS 1910-42-5
- Pentachlorophenol CAS 87-86-5
- pentan-3-one CAS 96-22-0
- pentanol isomers, with the exception fo those… Index No 603-006-00-7
- Pentyl formate CAS 638-49-3
- pepsin A CAS 9001-75-6
- perboric acid (H 3 BO 2(O2 )), monosodium salt… CAS 13517-20-9
- perboric acid, sodium salt [1] perboric acid, sodium… CAS 11138-47-9
- Phenoxyethanol CAS 122-99-6
- Phenyl glycidyl ether CAS 122-60-1
- Phosphorus tribromide CAS 7789-60-8
- Phthalic Anhydride CAS 85-44-9
- Pinoxaden CAS 243973-20-8
- Piperonyl Butoxide CAS 51-03-6
- poly-[((4-((4-(ethyl-ethylene)amino)phenyl)-(4-(ethyl-(… CAS 176429-22-4
- poly-[((4-((4-ethyl-ethylene)amino)phenyl)-((4-(ethyl-(… CAS 176429-27-9
- Potassium 2-hydroxy-9H-carbazole-1-carboxylate CAS 96566-70-0
- Potassium Chromate CAS 7789-00-6
- potassium hydrogensulphate CAS 7646-93-7
- Propanal CAS 123-38-6
- propyl formate [1] isopropyl formate [2] CAS 110-74-7
- Propylbenzene CAS 103-65-1
- Propylene Oxide CAS 75-56-9
- proteases with the exception of those specified… Index No 647-014-00-9
- proteinase, microbial neutral CAS 9068-59-1
- Pyraclostrobin CAS 175013-18-0
- reaction product of amorphous silica (50-85 %), butyl… Index No 014-043-00-8
- rennin CAS 9001-98-3
- sabadilla (ISO) CAS 8051-02-3
- salts and esters of 2,4,5-T Index No 607-042-00-4
- Silicon tetrachloride CAS 10026-04-7
- Sodium (hydroxymethyl)glycinate CAS 70161-44-3
- sodium 2-biphenylate CAS 132-27-4
- sodium 4-(2,4,4-trimethylpentylcarbonyloxy)benzenesulfo… Index No 016-054-00-3
- sodium pentachlorophenolate [1] potassium… CAS 131-52-2
- sodium peroxometaborate CAS 7632-04-4
- Sodium Silicate CAS 6834-92-0
- spirotetramat (ISO) CAS 203313-25-1
- subtilisin CAS 9014-01-1
- Sulfur dichloride CAS 10545-99-0
- Sulfuryl chloride CAS 7791-25-5
- symclosene CAS 87-90-1
- TCA-sodium (ISO) CAS 650-51-1
- tert-Butyl acrylate CAS 1663-39-4
- tetraethyl silicate CAS 78-10-4
- tetrahydrofuran CAS 109-99-9
- thiocarbonyl chloride CAS 463-71-8
- toluene diisocyanate CAS 91-08-7
- Tolylfluanid CAS 731-27-1
- Trichloromethylsilane CAS 75-79-6
- trichloronitromethane CAS 76-06-2
- Trimethylhydroquinone CAS 700-13-0
- trioctyltin compounds, with the exception of those… Index No 050-013-00-0
- troclosene potassium [1] troclosene sodium [2] CAS 2244-21-5
- troclosene sodium, dihydrate CAS 51580-86-0
- trypsin CAS 9002-07-7
- Vinyl Acetate CAS 108-05-4
- Zinc dibutyldithiocarbamate CAS 136-23-2
- Zinc Diethyldithiocarbamate CAS 14324-55-1
- Zineb CAS 12122-67-7
- Ziram CAS 137-30-4
- α-bromotoluene CAS 100-39-0
- α-chlorotoluene CAS 100-44-7
- α, α,α,4-tetrachlorotoluene CAS 5216-25-1
- α,α-dichlorotoluene CAS 98-87-3
- α,α,α-trichlorotoluene CAS 98-07-7
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All hazard statements
The full list of H-codes with the jurisdiction switch lives on the hazard statements hub. For what to do about the hazard, see precautionary statements (P-codes).
Wording quoted from the regulation named above. Substance counts come from harmonised classifications in CLP Annex VI — the statements on a real product also depend on the supplier's own classification. Always check the supplier safety data sheet.