Substance profile
4,4'-methylenedi(cyclohexyl isocyanate)
4,4'-methylenedi(cyclohexyl isocyanate) is a clear, colorless to light-yellow liquid.
01 · Identification
What 4,4'-methylenedi(cyclohexyl… is
4,4'-methylenedi(cyclohexyl isocyanate) is a clear, colorless to light-yellow liquid. Its molecular formula is C15H22N2O2 and its molecular weight is 262.35 g/mol. It melts at -10 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
4,4'-methylenedi(cyclohexyl… identifiers and molecular data
4,4'-methylenedi(cyclohexyl… CAS number and EC number
4,4'-methylenedi(cyclohexyl… molecular formula and molecular weight
Other names for 4,4'-methylenedi(cyclohexyl…
- dicyclohexylmethane-4,4'-di-isocyanate
03 · GHS classification
4,4'-methylenedi(cyclohexyl… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4,4'-methylenedi(cyclohexyl… pictograms and signal word
4,4'-methylenedi(cyclohexyl… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Respiratory sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H334 | GHS08 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4,4'-methylenedi(cyclohexyl… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H331 | Toxic if inhaled. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H317 | May cause an allergic skin reaction. |
This page lists only the codes assigned to 4,4'-methylenedi(cyclohexy…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4,4'-methylenedi(cyclohexy…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4,4'-methylenedi(cyclo… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4,4'-methylenedi(cyclohexyl… precautionary statements
CLP Annex VI assigns 16 precautionary statements to 4,4'-methylenedi(cyclohexy…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4,4'-methylenedi(cyclohexyl… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4,4′-метиленди(циклохексилов изоцианат) дициклохексилметан-4,4′-диизоцианат |
| Spanish español | 4,4'-Metilen-di(isocianato de ciclohexilo) 4,4'-di-isocianato de diciclohexilmetano |
| Czech čeština | 4,4'-methylendi(cyklohexyl-isokyanát) dicyklohexylmethan-4,4'-diisokyanát |
| Danish dansk | 4,4'-methylendi(cyclohexylisocyanat) dicyclohexylmethan-4,4'-diisocyanat |
| German Deutsch | 4,4'-Methylendi(cyclohexylisocyanat) Dicyclohexylmethan-4,4'-diisocyanat |
| Estonian eesti | 4,4'-metüleendi(tsükloheksüülisotsüanaat) ditsükloheksüülmetaan-4,4'-diisotsüanaat |
| Greek ελληνικά | 4,4′-μεθυλενοδι(ισοκυανικό κυκλοεξύλιο) 4,4′-διισοκυανο-δικυκλοεξυλομεθάνιο |
| English English | 4,4'-methylenedi(cyclohexyl isocyanate) dicyclohexylmethane-4,4'-di-isocyanate |
| French français | 4,4'-méthylènedi(cyclohexylisocyanate) dicyclohexylméthane-4,4'-di-isocyanate |
| Croatian hrvatski | 4,4'-metilendi(cikloheksil izocijanat) dicikloheksilmetan-4,4'-di-izocijanat |
| Italian italiano | metilen-bis (4-cicloesil isocianato) dicicloesilmetan-4,4'-diisocianato |
| Latvian latviešu | 4,4'-metilēndi(cikloheksilizocianāts) dicikloheksilmetān-4,4'-diizocianāts |
| Lithuanian lietuvių | 4,4'-metilendicikloheksildiizocianatas dicikloheksilmetan-4,4'-diizocianatas |
| Hungarian magyar | 4,4’-metiléndi(ciklohexil-izocianát) diciklohexilmetán-4,4’-diizocianát |
| Maltese Malti | 4,4'-metilendi(ċikloessil isoċjanat) diċikloessilmetan-4,4'-di-isoċjanat |
| Dutch Nederlands | 4,4'-methyleendi(cyclohexylisocyanaat) dicyclohexylmethane-4,4'-diisocyanaat |
| Polish polski | diizocyjanian 4,4'-metylenodicykloheksylu metylenobis(4-cykloheksyloizocyjanian)diizocyjanian metylenobis(4-cykloheksylu) |
| Portuguese português | bis(ciclo-hexilisocianato) de 4,4'-metileno 4,4'-diisocianato de diciclo-hexilmetano |
| Romanian română | 4,4'-metilenedi(ciclohexil izocianat) diizocianat de 4,4'-diciclohexilmetan |
| Slovak slovenčina | 4,4'-metyléndi(cyklohexylizokyanát) dicyklohexylmetán-4,4'-diizokyanát |
| Slovenian slovenščina | 4,4'-metilendi(cikloheksil izocianat) dicikloheksilmetan-4,4'-di-izocianat |
| Finnish suomi | 4,4'-metyleenidi(sykloheksyyli-isosyanaatti) disykloheksyylimetaani-4,4’-di-isosyanaatti |
| Swedish svenska | 4,4'-metylendi(cyklohexylisocyanat) dicyklohexylmetan-4,4'-diisocyanat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4,4'-methylenedi(cyclohexyl… GHS label elements
Everything CLP Annex VI fixes for 4,4'-methylenedi(cyclohexy…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4,4'-methylenedi(cyclohexyl…
- Toxic if inhaled.
- May cause respiratory irritation.
- Causes skin irritation.
- Causes serious eye irritation.
- May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- May cause an allergic skin reaction.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- If skin irritation occurs:
- If skin irritation or rash occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4,4'-methylenedi(cyclohexy… in the GHS label constructor →
07 · Health hazards
4,4'-methylenedi(cyclohexyl… health hazards and exposure limits
4,4'-methylenedi(cyclohexyl… occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 0.01 ppm (0.11 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | C 0.01 ppm (0.11 mg/m3) | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | N.D. | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
4,4'-methylenedi(cyclohexyl… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4,4'-methylenedi(cyclohexyl… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -10 °C (14 °F) | below this value | NIOSH |
4,4'-methylenedi(cyclohexyl… density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.066 g/cm³ | HSDB | |
| 1.07 g/cm³ | at 25 °C | CAMEO |
4,4'-methylenedi(cyclohexyl… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in acetone | HSDB | |
| Reacts | NIOSH | ||
| Reacts with water (NIOSH, 2024) | CAMEO |
4,4'-methylenedi(cyclohexyl… vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.001 mmHg | at 25 °C | HSDB |
4,4'-methylenedi(cyclohexyl… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 201.67 °C (395 °F) | above this value | NIOSH |
4,4'-methylenedi(cyclohexyl… lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Class IIIB Combustible Liquid: Fl.P. at or above 200 °F. | NIOSH |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
4,4'-methylenedi(cyclohexyl… storage and handling
4,4'-methylenedi(cyclohexyl… incompatible materials
Substance reacts with water. ...Dicyclohexylmethan-4,4'-diisocyanate reacts in comparison to hexamethylene diisocyanate very slowly with water and slowly with alcohols or amines; normally the reaction must be catalyzed with metal compounds.
Source: Hazardous Substances Data Bank (HSDB)
4,4'-methylenedi(cyclohexyl… reactivity
Isocyanates and thioisocyanates, such as 1,1-METHYLENE BIS(4-ISOCYANATOCYCLOHEXANE), are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer(1969)].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4,4'-methylenedi(cyclohex… in the storage compatibility matrix →
10 · Questions
4,4'-methylenedi(cyclohexyl… — frequently asked questions
What is the CAS number of 4,4'-methylenedi(cyclohexyl…?
The CAS number of 4,4'-methylenedi(cyclohexyl… is 5124-30-1. Its EC number is 225-863-2.
What is the chemical formula of 4,4'-methylenedi(cyclohexyl…?
The molecular formula of 4,4'-methylenedi(cyclohexyl… is C15H22N2O2 and its molecular weight is 262.35 g/mol.
What does a 4,4'-methylenedi(cyclohexyl… label have to show?
Under CLP Annex VI the label for 4,4'-methylenedi(cyclohexyl… carries the pictograms Skull and crossbones and Health hazard and the signal word is Danger.
Is 4,4'-methylenedi(cyclohexyl… flammable?
CLP Annex VI assigns 4,4'-methylenedi(cyclohexyl… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 201.67 °C (395 °F), above this value (NIOSH).
Is 4,4'-methylenedi(cyclohexyl… a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 4,4'-methylenedi(cyclohexyl…. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for 4,4'-methylenedi(cyclohexyl…?
The US occupational exposure limit reported for 4,4'-methylenedi(cyclohexyl… is none See Appendix G (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the melting point of 4,4'-methylenedi(cyclohexyl…?
The melting point reported for 4,4'-methylenedi(cyclohexyl… is -10 °C (14 °F), below this value (NIOSH).
Nearby
Substances next to 4,4'-methylenedi(cyclohexy…
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