Substance profile
Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
Benzene-1,2,4-tricarboxylic acid 1,2-anhydride is crystals.
01 · Identification
What Benzene-1,2,4-tricarboxylic… is
Benzene-1,2,4-tricarboxylic acid 1,2-anhydride is crystals. Its molecular formula is C9H4O5 and its molecular weight is 192.12 g/mol. It boils at 390 °C, melts at 161 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Benzene-1,2,4-tricarboxylic… identifiers and molecular data
Benzene-1,2,4-tricarboxylic… CAS number and EC number
Benzene-1,2,4-tricarboxylic… molecular formula and molecular weight
Other names for Benzene-1,2,4-tricarboxylic…
- trimellitic anhydride
03 · GHS classification
Benzene-1,2,4-tricarboxylic… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Benzene-1,2,4-tricarboxylic… pictograms and signal word
Benzene-1,2,4-tricarboxylic… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 1 | H318 | GHS05 |
| Respiratory sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H334 | GHS08 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Benzene-1,2,4-tricarboxylic… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H335 | May cause respiratory irritation. |
| H318 | Causes serious eye damage. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H317 | May cause an allergic skin reaction. |
This page lists only the codes assigned to Benzene-1,2,4-tricarboxyli…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Benzene-1,2,4-tricarboxyli…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Benzene-1,2,4-tricarbo… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Benzene-1,2,4-tricarboxylic… precautionary statements
CLP Annex VI assigns 8 precautionary statements to Benzene-1,2,4-tricarboxyli…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Benzene-1,2,4-tricarboxylic… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | бензен-1,2,4-трикарбоксилен 1,2-анхидрид тримелитов анхидрид |
| Spanish español | 1,2-Anhídrido del ácido benceno-1,2,4-tricarboxílico anhídrido trimelítico |
| Czech čeština | benzen-1,2,4-trikarbox-1,2-anhydrid 1,2-anhydrid-benzen-1,2,4-trikarboxylové kyseliny |
| Danish dansk | benzen-1,2,4-tricarboxylsyre-1,2-anhydrid trimellitsyreanhydrid |
| German Deutsch | 1,2,4-Benzoltricarbonsäure-1,2-anhydrid Trimellitsäureanhydrid |
| Estonian eesti | benseen-1,2,4-trikarboksüülhappe 1,2-anhüdriid trimelliitanhüdriid |
| Greek ελληνικά | βενζολο-1,2,4-τρικαρβοξυλικό οξύ, 1,2-ανυδρίτης τριμελλιτικός ανυδρίτης |
| English English | benzene-1,2,4-tricarboxylic acid 1,2-anhydride trimellitic anhydride |
| French français | acide 1,2,4-benzènedicarboxylique, 1,2-anhydre anhydride trimellitique |
| Croatian hrvatski | 1,2-anhidrid benzen-1,2,4-trikarboksilne kiseline anhidrid trimelitne kiseline |
| Italian italiano | 1,2-anidride dell'acido benzen-1,2,4-tricarbossilico |
| Latvian latviešu | benzol-1,2,4-trikarbonskābes 1,2-anhidrīds trimelitskābes anhidrīds |
| Lithuanian lietuvių | benzen-1,2,4-trikarboksrūgšties 1,2-anhidridas trimelito rūgšties anhidridas |
| Hungarian magyar | benzol-1,2,4-trikarbonsav-1,2-anhidrid trimellit-anhidrid |
| Maltese Malti | 1,2-anidride tal-aċidu benzen-1,2,4-trikarbossiliku anidride trimetilliku |
| Dutch Nederlands | benzeen-1,2,4-tricarbonzuur-1,2-anhydride trimellietzuuranhydride |
| Polish polski | 1,2-bezwodnik kwasu benzeno-1,2,4-trikarboksylowego bezwodnik trimelitowy |
| Portuguese português | 1,2-anidrido de ácido benzeno-1,2,4-tricarboxílico anidrido trimelítico |
| Romanian română | 1,2-anhidrida acidului benzen-1,2,4-tricarboxilic anhidridă trimelitică |
| Slovak slovenčina | 1,2-anhydrid kyseliny benzén-1,2,4-trikarboxylovej anhydrid kyseliny trimellitovej |
| Slovenian slovenščina | benzen-1,2,4-trikarboksilna kislina 1,2-anhidrid anhidrid trimelitne kisline |
| Finnish suomi | bentseeni-1,2,4-trikarboksyylihapon 1,2-anhydridi trimellitiinihappoanhydridi |
| Swedish svenska | bensen-1,2,4-trikarboxylsyra-1,2-anhydrid trimellitsyraanhydrid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Benzene-1,2,4-tricarboxylic… GHS label elements
Everything CLP Annex VI fixes for Benzene-1,2,4-tricarboxyli…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Benzene-1,2,4-tricarboxylic…
- May cause respiratory irritation.
- Causes serious eye damage.
- May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- May cause an allergic skin reaction.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Contaminated work clothing should not be allowed out of the workplace.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- If skin irritation or rash occurs:
- Remove contact lenses, if present and easy to do. Continue rinsing.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Benzene-1,2,4-tricarboxyli… in the GHS label constructor →
07 · Health hazards
Benzene-1,2,4-tricarboxylic… health hazards and exposure limits
Benzene-1,2,4-tricarboxylic… hazard summary
There are three syndromes caused by trimellitic anhydride (TMA) based on its ability to irritate and sensitize lung tissue. Sensitized workers can develop upon re-exposure 1) asthma-rhinitis; 2) late respiratory systemic syndrome (LRSS); or very rarely 3) pulmonary disease anemia syndrome (PDA). [Grammer LC et al. Review of trimellitic anhydride (TMA) induced respiratory response. Allergy Asthma Proc 1997 Jul-Aug;18(4):235-7] Workers exposed to less than 0.002 mg/m3 are at low risk for developing disease. [Grammer LC et al. A Clinical and Immunologic Study to Assess Risk of TMA-Induced Lung Disease as Related to Exposure. JOEM 1999 Dec;41(12):1048-51] TMAN is a potent sensitizer after inhalation of either dust or fume. It causes IgE and IgG mediated disease (asthma/rhinitis, late respiratory systemic syndrome, pulmonary disease anemia, and late arthralgia myalgia). Symptoms include sneezing, rhinitis, dry throat, watery eyes, conjunctivitis, and dyspnea. Dermal contact may cause or exacerbate respiratory sensitization. When workers are not exposed to >2 ug/m3, there are no cases of disease or IgG against TM-HAS (Human Serum Albumin), but there are still cases of non-diseased workers with IgE against TM-HAS (9% incidence). TMAN cause both immediate and delayed dermal sensitization in animal studies. [ACGIH] Danger of airway sensitization; [MAK] TMA skin testing provides an alternative and potentially more practical method for monitoring TMA-exposed workers for developing IgE sensitization. [PMID 21915071] See ACID ANHYDRIDES.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Benzene-1,2,4-tricarboxylic… occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 0.005 ppm (0.04 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 0.005 ppm (0.04 mg/m3) Should be handled in the workplace as an extremely toxic substance. | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | N.D. | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Benzene-1,2,4-tricarboxylic… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Benzene-1,2,4-tricarboxylic… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 390 °C (734 °F) | HSDB | |
| 242.5 °C (468.5 °F) | range, midpoint shown, at 14 mmHg (reduced pressure) | HSDB |
Benzene-1,2,4-tricarboxylic… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 161.11 °C (322 °F) | NIOSH | |
| 162.25 °C (324.1 °F) | range, midpoint shown | HSDB | |
| 166.94 °C (332.5 °F) | range, midpoint shown | CAMEO |
Benzene-1,2,4-tricarboxylic… density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.55 g/cm³ | at 20 °C | CAMEO |
Benzene-1,2,4-tricarboxylic… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) | at 20 °C | CAMEO |
| 36.5 g/100 g 2-butanone at 25 °C; 38.4 g/100 g cyclohexanone at 25 °C; 0.06 g/100 g mineral spirits at 25 °C | at 25 °C | HSDB |
Benzene-1,2,4-tricarboxylic… vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000004 mmHg | HSDB | |
| 0.000004 mmHg | at 25 °C | CAMEO |
Benzene-1,2,4-tricarboxylic… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 227 °C (440.6 °F) | CAMEO |
Benzene-1,2,4-tricarboxylic… lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Finely dispersed particles form explosive mixtures in air. | HSDB | |
| Combustible Solid | NIOSH |
Benzene-1,2,4-tricarboxylic… vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 6.6 (air = 1) | HSDB |
Benzene-1,2,4-tricarboxylic… critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 569 °C (1056.2 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Benzene-1,2,4-tricarboxyli… fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Benzene-1,2,4-tricarboxylic… fire potential
Combustible.
Source: Hazardous Substances Data Bank (HSDB)
Solubility
Sol at 25 °C: 0.002 g/100 g carbon tetrachloride; 0.06 g/100 g ligroin; 0.4 g/100 g mixed xylenes; 15.5 g/100 g dimethyl formamide; 49.6 g/100 g acetone; 21.6 g/100 g ethyl acetate
Source: HSDB
10 · Handling and storage
Benzene-1,2,4-tricarboxylic… storage and handling
Benzene-1,2,4-tricarboxylic… safe storage
Dry. Separated from bases and strong oxidants. Ventilation along the floor.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Benzene-1,2,4-tricarboxylic… storage conditions
Dry. Separated from bases and strong oxidants. Ventilation along the floor.
Source: Hazardous Substances Data Bank (HSDB)
Benzene-1,2,4-tricarboxylic… incompatible materials
Reacts violently with bases and oxidants. Reacts slowly with water to form trimellitic acid.
Source: Hazardous Substances Data Bank (HSDB)
Benzene-1,2,4-tricarboxylic… reactivity
TRIMELLITIC ANHYDRIDE reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Incompatible with strong oxidizing agents, strong acids or strong bases. (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Benzene-1,2,4-tricarboxyl… in the storage compatibility matrix →
11 · Questions
Benzene-1,2,4-tricarboxylic… — frequently asked questions
What is the CAS number of Benzene-1,2,4-tricarboxylic…?
The CAS number of Benzene-1,2,4-tricarboxylic… is 552-30-7. Its EC number is 209-008-0.
What is the chemical formula of Benzene-1,2,4-tricarboxylic…?
The molecular formula of Benzene-1,2,4-tricarboxylic… is C9H4O5 and its molecular weight is 192.12 g/mol.
What does a Benzene-1,2,4-tricarboxylic… label have to show?
Under CLP Annex VI the label for Benzene-1,2,4-tricarboxylic… carries the pictograms Health hazard, Corrosion and Exclamation mark and the signal word is Danger.
Is Benzene-1,2,4-tricarboxylic… flammable?
CLP Annex VI assigns Benzene-1,2,4-tricarboxylic… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 227 °C (440.6 °F) (CAMEO).
Is Benzene-1,2,4-tricarboxylic… a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Benzene-1,2,4-tricarboxylic…. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for Benzene-1,2,4-tricarboxylic…?
The US occupational exposure limit reported for Benzene-1,2,4-tricarboxylic… is none See Appendix G (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Benzene-1,2,4-tricarboxylic…?
The boiling point reported for Benzene-1,2,4-tricarboxylic… is 390 °C (734 °F) (HSDB).
What is the melting point of Benzene-1,2,4-tricarboxylic…?
The melting point reported for Benzene-1,2,4-tricarboxylic… is 161.11 °C (322 °F) (NIOSH).
How should Benzene-1,2,4-tricarboxylic… be stored?
Dry. Separated from bases and strong oxidants. Ventilation along the floor. (Hazardous Substances Data Bank (HSDB))
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