2,3-epoxypropan-1-ol

Mice and rats exposed to high concentrations develop pneumonitis and emphysema; Rabbits show skin irritation and reversible corneal burns after skin and eye exposure; [ACGIH] In lethal inhalation studies of rodents, pulmonary edema was usually the cause of death; There is no experimental data, but glycidol, an epoxide, should be considered a potential skin and respiratory sensitizer; [HSDB]

Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of glycidol for male F344/N rats, based on increased incidences of mesotheliomas of the tunica vaginalis; fibroadenomas of the mammary gland; gliomas of the brain; and neoplasms of the forestomach, intestine, skin, Zymbal gland, and thyroid gland. There was clear evidence of carcinogenic activity for female F344/N rats, based on increased incidences of fibroadenomas and adenocarcinomas of the mammary gland; gliomas of the brain; neoplasms of the oral mucosa, forestomach, clitoral gland, and thyroid gland; and leukemia. There was clear evidence of carcinogenic activity for male B6C3F1 mice based on increased incidences of neoplasms of the harderian gland, forestomach, skin, liver, and lung. There was clear evidence of carcinogenic activity for female B6C3F1 mice, based on increased incidences of neoplasms of the harderian gland, mammary gland, uterus, subcutaneous tissue, and skin. Other neoplasms that may have been related to the administration of glycidol were fibrosarcomas of the glandular stomach in female rats and carcinomas of the urinary bladder and sarcomas of the epididymis in male mice.

Source: US National Toxicology Program · TR-374: Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies) (1990 )

No epidemiological data relevant to the carcinogenicity of glycidol were available. There is sufficient evidence in experimental animals for the carcinogenicity of glycidol. Overall evaluation: Glycidol is probably carcinogenic to humans (Group 2A).

Source: Hazardous Substances Data Bank (HSDB)

Glycidol: reasonably anticipated to be a human carcinogen.

Source: Hazardous Substances Data Bank (HSDB)

2,3-epoxypropan-1-ol safe storage

Store only if stabilized. Cool. Dry. Well closed. Ventilation along the floor. Separated from strong bases, strong acids and food and feedstuffs.

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

2,3-epoxypropan-1-ol storage conditions

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Moisture sensitive. Handle and store under inert gas.

Source: Hazardous Substances Data Bank (HSDB)

2,3-epoxypropan-1-ol incompatible materials

Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts (e.g., aluminum chloride, ferric chloride, tin chloride) or metals (copper, zinc), causing fire and explosion hazard ... Attacks some plactics, rubber, and coatings.

Source: Hazardous Substances Data Bank (HSDB)

2,3-epoxypropan-1-ol reactivity

GLYCIDOL is sensitive to moisture. It is also sensitive to light. It may polymerize if heated above room temperature. It may darken on storage. Stability studies of this chemical stored for two week protected from light indicated definite decomposition at 140 °F, and strongly indicated instability at 77 °F. A solution of this compound in water was found to be unstable when stored at room temperature, even after one day in the dark. This chemical is incompatible with strong oxidizers. It will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). It is also incompatible with nitrates. It will attack some forms of plastics, rubber and coatings. (NTP, 1992)

Source: CAMEO Chemicals