Substance profile
Bronopol
Bronopol is a white crystalline powder and is odorless.
01 · Identification
What Bronopol is
Bronopol is a white crystalline powder and is odorless. Its molecular formula is C3H6BrNO4 and its molecular weight is 199.99 g/mol. It boils at 152 °C, melts at 132 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Bronopol identifiers and molecular data
Bronopol CAS number and EC number
Bronopol molecular formula and molecular weight
Other names for Bronopol
- bronopol (INN)
- 2-bromo-2-nitropropane-1,3-diol
03 · GHS classification
Bronopol hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Bronopol pictograms and signal word
Bronopol hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 1 | H318 | GHS05 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
Bronopol hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H312 | Harmful in contact with skin. |
| H302 | Harmful if swallowed. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H318 | Causes serious eye damage. |
| H400 | Very toxic to aquatic life. |
This page lists only the codes assigned to Bronopol. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Bronopol
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Bronopol issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Bronopol precautionary statements
CLP Annex VI assigns 16 precautionary statements to Bronopol. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Bronopol name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | бронопол (INN) 2-бромо-2-нитропропан-1,3-диол |
| Spanish español | Bronopol (DCI) 2-bromo-2-nitropropano-1,3-diol |
| Czech čeština | bronopol (INN) 2-brom-2-nitropropan-1,3-diol |
| Danish dansk | bronopol (INN) 2-brom-2-nitropropan-1,3-diol |
| German Deutsch | Bronopol (INN) 2-Brom-2-nitropropan-1,3-diol |
| Estonian eesti | bronopool (INN) 2-bromo-2-nitropropaan-1,3-diool |
| Greek ελληνικά | bronopol (βρωνοπόλη) (INN) 2-βρωμο-2-νιτροπροπανο-1,3-διόλη |
| English English | bronopol (INN) 2-bromo-2-nitropropane-1,3-diol |
| French français | bronopol (INN) 2-bromo-2-nitropropane-1,3-diol |
| Croatian hrvatski | bronopol (INN) 2-brom-2-nitropropan-1,3-diol |
| Italian italiano | bronopol (DCI) 2-bromo-2-nitropropan-1,3-diolo |
| Latvian latviešu | bronopols (INN) 2-brom-2-nitropropān-1,3-diols |
| Lithuanian lietuvių | bronopolis (INN) 2-brom-2-nitropropan-1,3-diolis |
| Hungarian magyar | bronopol (INN) 2-bróm-2-nitropropán-1,3-diol |
| Maltese Malti | bronopol (INN) 2-bromo-2-nitropropan-1,3-diol |
| Dutch Nederlands | bronopol (INN) 2-broom-2-nitropropaan-1,3-diol |
| Polish polski | bronopol (INN) 2-bromo-2-nitropropano-1,3-diol |
| Portuguese português | bronopol (DCI) 2-bromo-2-nitropropano-1,3-diol |
| Romanian română | bronopol (DCI) 2-bromo-2-nitropropan-1,3-diol |
| Slovak slovenčina | bronopol (INN) 2-bróm-2-nitropropán-1,3-diol |
| Slovenian slovenščina | bronopol (INN) 2-bromo-2-nitropropan-1,3-diol |
| Finnish suomi | bronopoli (INN) 2-bromi-2-nitropropaani-1,3-dioli |
| Swedish svenska | bronopol (INN) 2-brom-2-nitropropan-1,3-diol |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Bronopol GHS label elements
Everything CLP Annex VI fixes for Bronopol, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Bronopol
- Harmful in contact with skin.
- Harmful if swallowed.
- May cause respiratory irritation.
- Causes skin irritation.
- Causes serious eye damage.
- Very toxic to aquatic life.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Bronopol in the GHS label constructor →
07 · Health hazards
Bronopol health hazards and exposure limits
Bronopol hazard summary
Bronopol is a skin sensitizer. Cosmetic preparations contain concentrations of 0.01% to 0.02%. Significant irritant effects are seen when the concentration reaches 1% or greater. [Marks, p. 136-7] Skin sensitization reported in dairy workers and a veterinarian using a gel for ultrasound examinations; [Kanerva, p. 1762] A skin, eye, and respiratory tract irritant; A skin sensitizer; [ICSC]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Bronopol carcinogenicity classification
Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Bronopol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Bronopol boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 151.72 °C (305.1 °F) | at 760 mmHg | CAMEO |
| 130 °C (266 °F) | DrugBank |
Bronopol melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 131.5 °C (268.7 °F) | HSDB | |
| 131.39 °C (268.5 °F) | range, midpoint shown | CAMEO | |
| 121 °C (249.8 °F) | range, midpoint shown | ICSC |
Bronopol density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.9 g/cm³ | ICSC |
Bronopol solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In water, 2.5X10+5 mg/L at 22 °C | at 22 °C | HSDB |
| Soluble in alcohol, ethyl acetate. Slightly soluble in chloroform, acetone, ether, benzene. Insoluble in ligroin. | HSDB | ||
| Solubility in water, g/100ml at 23 °C: 28 (freely soluble) | at 23 °C | ICSC |
Bronopol vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0000126 mmHg | at 20 °C | HSDB |
| Vapor pressure, Pa at 20 °C: | at 20 °C | ICSC |
Bronopol flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 167 °C (332.6 °F) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Bronopol fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Bronopol fire potential
Combustible.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Bronopol storage and handling
Bronopol safe storage
Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Bronopol storage conditions
Keep container tightly closed in a dry well-ventilated place.
Source: Hazardous Substances Data Bank (HSDB)
Bronopol incompatible materials
An aqueous solution of bronopol degrades in the presence of cupric and ferric ions as well as aluminum and tin metals.
Source: Hazardous Substances Data Bank (HSDB)
Bronopol reactivity
Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and acid anhydrides. It is also incompatible with sulfhydryl compounds or with aluminum or iron containers (it is stable in contact with tin or stainless steel). (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Bronopol in the storage compatibility matrix →
11 · Transport
Bronopol UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
Bronopol under UN 3241 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| 2-BROMO-2-NITROPROPANE-1,3- DIOL | 4.1 | SR1 | III | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 4.1 is “Flammable solids, self-reactive substances, polymerizing substances and solid desensitized explosives” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| 2-Bromo-2-nitropropane-1,3-diol | 4.1 | III | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 4.1 is “Flammable solid” (49 CFR 173.2).
12 · Questions
Bronopol — frequently asked questions
What is the CAS number of Bronopol?
The CAS number of Bronopol is 52-51-7. Its EC number is 200-143-0.
What is the chemical formula of Bronopol?
The molecular formula of Bronopol is C3H6BrNO4 and its molecular weight is 199.99 g/mol.
What does a Bronopol label have to show?
Under CLP Annex VI the label for Bronopol carries the pictograms Corrosion, Exclamation mark and Environment and the signal word is Danger.
Is Bronopol flammable?
CLP Annex VI assigns Bronopol no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 167 °C (332.6 °F) (ICSC).
Is Bronopol a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Bronopol. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Bronopol?
The boiling point reported for Bronopol is 151.72 °C (305.1 °F), at 760 mmHg (CAMEO).
What is the melting point of Bronopol?
The melting point reported for Bronopol is 131.5 °C (268.7 °F) (HSDB).
How should Bronopol be stored?
Keep container tightly closed in a dry well-ventilated place. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Bronopol
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