Substance profile
Brucine
Brucine is needles from acetone + water and is odorless.
01 · Identification
What Brucine is
Brucine is needles from acetone + water and is odorless. Its molecular formula is C23H26N2O4 and its molecular weight is 394.5 g/mol. It boils at 470 °C, melts at 178 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Brucine identifiers and molecular data
Brucine CAS number and EC number
Brucine molecular formula and molecular weight
Other names for Brucine
- 2,3-dimethoxystrychnine
03 · GHS classification
Brucine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Brucine pictograms and signal word
Brucine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 1 or 2 | H300 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 3 | H412 | — |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Brucine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H330 | Fatal if inhaled. |
| H300 | Fatal if swallowed. |
| H412 | Harmful to aquatic life with long lasting effects. |
This page lists only the codes assigned to Brucine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Brucine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Brucine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Brucine precautionary statements
CLP Annex VI assigns 9 precautionary statements to Brucine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Brucine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | бруцин 2,3-диметоксистрихнин |
| Spanish español | Brucina 2,3-dimetoxiestricnina |
| Czech čeština | brucin 2,3-dimethoxystrychnidin-10-on |
| Danish dansk | brucin 2,3-dimethoxystrychnin |
| German Deutsch | Brucin 2,3-Dimethoxystrychnin |
| Estonian eesti | brutsiin 2,3-dimetoksüstrühniin |
| Greek ελληνικά | βρυκίνη 2,3-διμεθοξυστρυχνίνη |
| English English | brucine 2,3-dimethoxystrychnine |
| French français | brucine 2,3-diméthoxystrychnine |
| Croatian hrvatski | brucin 2,3-dimetoksistrihnin |
| Italian italiano | brucina 2,3-dimetossistricnina |
| Latvian latviešu | brucīns 2,3-dimetoksistrihnīns |
| Lithuanian lietuvių | brucinas 2,3-dimetoksistrichninas |
| Hungarian magyar | brucin 2,3-dimetoxisztrichnin |
| Maltese Malti | bruċina 2,3-dimetossistriknina |
| Dutch Nederlands | brucine 2,3-dimethoxystrychnine |
| Polish polski | brucyna 2,3-dimetoksystrychnina |
| Portuguese português | brucina 2,3-dimetoxiestricnina |
| Romanian română | brucină 2,3-dimetoxistricnină |
| Slovak slovenčina | brucín 2,3-dimetoxystrychnín |
| Slovenian slovenščina | brucin 2,3-dimetoksistrihnin |
| Finnish suomi | brusiini 2,3-dimetoksistrykniini |
| Swedish svenska | brucin 2,3-dimetoxistryknin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Brucine GHS label elements
Everything CLP Annex VI fixes for Brucine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Brucine
- Fatal if inhaled.
- Fatal if swallowed.
- Harmful to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- IF SWALLOWED:
- IF INHALED:
- Immediately call a POISON CENTER/doctor/…
- Rinse mouth.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Brucine in the GHS label constructor →
07 · Physical and chemical properties
Brucine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Brucine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 470 °C (878 °F) | HSDB | |
| 470 °C (878 °F) | at 760 mmHg | DOE PAC |
Brucine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 178 °C (352.4 °F) | HSDB | |
| 177.78 °C (352 °F) | CAMEO |
Brucine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1 g/cm³ | at 20 °C | CAMEO |
Brucine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Crystals. Sol in water or alcohol. The solns are neutral or slightly acid. | Hydrochloride | HSDB |
| Prisms, dec 230 °C. Sol in water or alcohol. | Nitrate dihydrate | HSDB | |
| Slightly soluble in ethyl ether and benzene; very soluble in ethanol. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
08 · Fire and explosion
Brucine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Brucine fire potential
It is combustible though it may require some effort to ignite.
Source: Hazardous Substances Data Bank (HSDB)
09 · Handling and storage
Brucine storage and handling
Brucine safe storage
Separated from strong oxidants and food and feedstuffs. Dry. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Brucine storage conditions
Storage temperature: Ambient
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Brucine in the storage compatibility matrix →
10 · Transport
Brucine UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
Brucine under UN 1570 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| BRUCINE | 6.1 | T2 | I | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 6.1 is “Toxic substances” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Brucine | 6.1 | I | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 6.1 is “Poisonous materials” (49 CFR 173.2).
11 · Questions
Brucine — frequently asked questions
What is the CAS number of Brucine?
The CAS number of Brucine is 357-57-3. Its EC number is 206-614-7.
What is the chemical formula of Brucine?
The molecular formula of Brucine is C23H26N2O4 and its molecular weight is 394.5 g/mol.
What does a Brucine label have to show?
Under CLP Annex VI the label for Brucine carries the pictogram Skull and crossbones and the signal word is Danger.
Is Brucine flammable?
CLP Annex VI assigns Brucine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Brucine a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Brucine. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Brucine?
The boiling point reported for Brucine is 470 °C (878 °F) (HSDB).
What is the melting point of Brucine?
The melting point reported for Brucine is 178 °C (352.4 °F) (HSDB).
How should Brucine be stored?
Storage temperature: Ambient (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Brucine
Keep going: substances starting with B, or search the whole database by name, CAS number, pictogram or signal word.