Substance profile
Hexamethylene diisocyanate
Hexamethylene diisocyanate is a liquid with a sharp, pungent odor.
01 · Identification
What Hexamethylene diisocyanate is
Hexamethylene diisocyanate is a liquid with a sharp, pungent odor. Its molecular formula is C8H12N2O2 and its molecular weight is 168.19 g/mol. It boils at 213 °C, melts at -67 °C.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
Hexamethylene diisocyanate identifiers and molecular data
Hexamethylene diisocyanate CAS number and EC number
Hexamethylene diisocyanate molecular formula and molecular weight
Other names for Hexamethylene diisocyanate
- hexamethylene-di-isocyanate
03 · GHS classification
Hexamethylene diisocyanate hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Hexamethylene diisocyanate pictograms and signal word
Hexamethylene diisocyanate hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Respiratory sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H334 | GHS08 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Hexamethylene diisocyanate hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H331 | Toxic if inhaled. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H317 | May cause an allergic skin reaction. |
This page lists only the codes assigned to Hexamethylene diisocyanate. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Hexamethylene diisocyanate
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Hexamethylene diisocya… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Hexamethylene diisocyanate precautionary statements
CLP Annex VI assigns 16 precautionary statements to Hexamethylene diisocyanate. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Hexamethylene diisocyanate name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | хексаметилендиизоцианат |
| Spanish español | Di-isocianato de hexametileno |
| Czech čeština | hexamethylen-1,6-diisokyanát |
| Danish dansk | hexamethylen-1,6-diisocyanat |
| German Deutsch | Hexamethylendiisocyanat |
| Estonian eesti | heksametüleendiisotsüanaat |
| Greek ελληνικά | διισοκυανικό εξαμεθυλένιο |
| English English | hexamethylene-di-isocyanate |
| French français | di-isocyanate d'hexaméthylène |
| Croatian hrvatski | heksametilen-di-izocijanat |
| Italian italiano | esametilen diisocianato |
| Latvian latviešu | heksametilēna diizocianāts |
| Lithuanian lietuvių | heksametilendiizocianatas |
| Hungarian magyar | hexametilén-diizocianát |
| Maltese Malti | essametilen-di-isoċjanat |
| Dutch Nederlands | hexamethyleen-diisocyanaat |
| Polish polski | diizocyjanian heksametylenu diizocyjanian heksano-1,6-diylu |
| Portuguese português | diisocianato de hexametileno |
| Romanian română | diizocianat de hexametilen |
| Slovak slovenčina | hexán-1,6-diyldiizokyanát |
| Slovenian slovenščina | heksametilen di-izocianat |
| Finnish suomi | heksametyleeni-1,6-di-isosyanaatti |
| Swedish svenska | hexametylendiisocyanat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Hexamethylene diisocyanate GHS label elements
Everything CLP Annex VI fixes for Hexamethylene diisocyanate, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Hexamethylene diisocyanate
- Toxic if inhaled.
- May cause respiratory irritation.
- Causes skin irritation.
- Causes serious eye irritation.
- May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- May cause an allergic skin reaction.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- If skin irritation occurs:
- If skin irritation or rash occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Hexamethylene diisocyanate in the GHS label constructor →
07 · Health hazards
Hexamethylene diisocyanate health hazards and exposure limits
Hexamethylene diisocyanate hazard summary
Hexamethylene diisocyanate is a pale yellow liquid with a strong odor. It is an industrial chemical that is not known to occur naturally. It is also commonly known as HDI, 1,6-hexamethylene diisocyanate, 1,6-diisocyanatohexane, Mondur HX, and Desmodur H. Hexamethylene diisocyanate is mainly used to make polyurethane foams and coatings. It is also used as a hardener in automobile and airplane paints.
Source: Agency for Toxic Substances and Disease Registry (ATSDR)
Hexamethylene diisocyanate occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 0.005 ppm (0.035 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | 0.020 ppm (0.140 mg/m³) [10 minutes] | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 0.005 ppm (0.035 mg/m3) C 0.020 ppm (0.140 mg/m3) [10-minute] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | N.D. | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Hexamethylene diisocyanate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Hexamethylene diisocyanate boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 213 °C (415.4 °F) | HSDB | |
| 212.78 °C (415 °F) | NIOSH | ||
| 255 °C (491 °F) | at 760 mmHg | CAMEO |
Hexamethylene diisocyanate melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -67 °C (-88.6 °F) | HSDB | |
| -67.22 °C (-89 °F) | NIOSH | ||
| -55 °C (-67 °F) | CAMEO |
Hexamethylene diisocyanate density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.05 g/cm³ | ICSC | |
| 1.0528 g/cm³ | at 20 °C | CAMEO | |
| 1.04 g/cm³ | at 25 °C | HSDB |
Hexamethylene diisocyanate solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Low (Reacts) | NIOSH | |
| Reacts with water (NTP, 1992) | CAMEO | ||
| Solubility in water: reaction | ICSC |
Hexamethylene diisocyanate vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.05 mmHg | at 23.89 °C | CAMEO |
| 0.05 mmHg | at 25 °C | HSDB |
Hexamethylene diisocyanate flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 140 °C (284 °F) | NIOSH |
Hexamethylene diisocyanate autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 454 °C (849.2 °F) | ICSC |
Hexamethylene diisocyanate lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 0.9 % by volume | ICSC | |
| Class IIIB Combustible Liquid: Fl.P. at or above 200 °F. | NIOSH |
Hexamethylene diisocyanate upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 9.5 % by volume | ICSC |
Hexamethylene diisocyanate vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 5.81 (air = 1) | HSDB | |
| 5.8 (air = 1) | ICSC |
Hexamethylene diisocyanate odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | The absolute perception limit is 0.001 ppm and 100% recognition at 0.02 ppm. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
Hexamethylene diisocyanate storage and handling
Hexamethylene diisocyanate safe storage
Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. Cool. Dry. Keep in the dark. Ventilation along the floor.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Hexamethylene diisocyanate storage conditions
Isocyanates are transported in railroad tank cars, tank trucks, tanks in ships, containers, and drums. They are stored in steel tanks and processed in steel equipment. For long-term storage stainless steel is recommended. To avoid contamination by atmospheric moisture, a dry air or inert gas blanket is essential. /Isocyanates/
Source: Hazardous Substances Data Bank (HSDB)
Hexamethylene diisocyanate incompatible materials
Base-catalyzed reactions of isocyanates such as hexamethylene diisocyanate with alcohols should generally be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence.
Source: Hazardous Substances Data Bank (HSDB)
Hexamethylene diisocyanate reactivity
HEXAMETHYLENE DIISOCYANATE reacts with water. Base-catalyzed reactions of this compound with alcohols may be explosively violent in the absence of diluting solvents. This chemical is incompatible with strong bases, amines, acids and strong oxidizers. It is also incompatible with metal compounds and surface active materials. (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Hexamethylene diisocyanat… in the storage compatibility matrix →
10 · Questions
Hexamethylene diisocyanate — frequently asked questions
What is the CAS number of Hexamethylene diisocyanate?
The CAS number of Hexamethylene diisocyanate is 822-06-0. Its EC number is 212-485-8.
What is the chemical formula of Hexamethylene diisocyanate?
The molecular formula of Hexamethylene diisocyanate is C8H12N2O2 and its molecular weight is 168.19 g/mol.
What does a Hexamethylene diisocyanate label have to show?
Under CLP Annex VI the label for Hexamethylene diisocyanate carries the pictograms Skull and crossbones and Health hazard and the signal word is Danger.
Is Hexamethylene diisocyanate flammable?
CLP Annex VI assigns Hexamethylene diisocyanate no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 140 °C (284 °F) (NIOSH).
Is Hexamethylene diisocyanate a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Hexamethylene diisocyanate. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for Hexamethylene diisocyanate?
The US occupational exposure limit reported for Hexamethylene diisocyanate is none (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Hexamethylene diisocyanate?
The boiling point reported for Hexamethylene diisocyanate is 213 °C (415.4 °F) (HSDB).
What is the melting point of Hexamethylene diisocyanate?
The melting point reported for Hexamethylene diisocyanate is -67 °C (-88.6 °F) (HSDB).
How should Hexamethylene diisocyanate be stored?
Isocyanates are transported in railroad tank cars, tank trucks, tanks in ships, containers, and drums. They are stored in steel tanks and processed in steel equipment. For long-term storage stainless steel is recommended. To avoid contamination by atmospheric moisture, a dry air or inert gas blanket is essential. /Isocyanates/ (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Hexamethylene diisocyanate
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