Substance profile
1,3,5-Trioxane
1,3,5-Trioxane is a crystalline solid with a characteristic chloroform-like odor.
01 · Identification
What 1,3,5-Trioxane is
1,3,5-Trioxane is a crystalline solid with a characteristic chloroform-like odor. Its molecular formula is C3H6O3 and its molecular weight is 90.08 g/mol. It boils at 115 °C, melts at 64 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
1,3,5-Trioxane identifiers and molecular data
1,3,5-Trioxane CAS number and EC number
1,3,5-Trioxane molecular formula and molecular weight
Other names for 1,3,5-Trioxane
- 1,3,5-trioxan
- trioxymethylene
03 · GHS classification
1,3,5-Trioxane hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
1,3,5-Trioxane pictograms and signal word
1,3,5-Trioxane hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Flammable solids GHS chapter 2.7 | Category 1 or 2 | H228 | GHS02 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
1,3,5-Trioxane hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H228 | Flammable solid. |
| H361d | Suspected of damaging the unborn child. |
| H335 | May cause respiratory irritation. |
This page lists only the codes assigned to 1,3,5-Trioxane. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 1,3,5-Trioxane
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,3,5-Trioxane issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
1,3,5-Trioxane precautionary statements
CLP Annex VI assigns 4 precautionary statements to 1,3,5-Trioxane. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
1,3,5-Trioxane name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 1,3,5-триоксан триоксиметилен |
| Spanish español | 1,3,5-Trioxano trioximetileno |
| Czech čeština | 1,3,5-trioxan trioxymethylen |
| Danish dansk | 1,3,5-trioxan trioxymethylen |
| German Deutsch | 1,3,5-Trioxan Trioxymethylen |
| Estonian eesti | 1,3,5-trioksaan trioksümetüleen |
| Greek ελληνικά | 1,3,5-τριοξάνιο τριοξυμεθυλένιο |
| English English | 1,3,5-trioxan trioxymethylene |
| French français | 1,3,5-trioxane trioxyméthylène |
| Croatian hrvatski | 1,3,5-trioksan trioksimetilen |
| Italian italiano | 1,3,5-triossano triossimetilene |
| Latvian latviešu | 1,3,5-trioksāns trioksimetilēns |
| Lithuanian lietuvių | 1,3,5-trioksanas trioksimetilenas |
| Hungarian magyar | 1,3,5-trioxán trioximetilén |
| Maltese Malti | 1,3,5-triossan triossimetilen |
| Dutch Nederlands | 1,3,5-trioxaan trioxymethyleen |
| Polish polski | 1,3,5-trioksan trioksymetylen |
| Portuguese português | 1,3,5-trioxano trioximetileno |
| Romanian română | 1,3,5-trioxan trioximetilen |
| Slovak slovenčina | 1,3,5-trioxán trioxymetylén |
| Slovenian slovenščina | 1,3,5-trioksan trioksimetilen |
| Finnish suomi | 1,3,5-trioksaani trioksimetyleeni |
| Swedish svenska | 1,3,5-trioxan trioximetylen |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
1,3,5-Trioxane GHS label elements
Everything CLP Annex VI fixes for 1,3,5-Trioxane, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
1,3,5-Trioxane
- Flammable solid.
- Suspected of damaging the unborn child.
- May cause respiratory irritation.
- Obtain special instructions before use.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 1,3,5-Trioxane in the GHS label constructor →
07 · Health hazards
1,3,5-Trioxane health hazards and exposure limits
1,3,5-Trioxane hazard summary
Cyclic trimer of formaldehyde; [Merck Index] A respiratory tract irritant; [eChemPortal: ESIS] Slowly releases formaldehyde at body temperature; Has same toxicity as formaldehyde after absorption into the body; [HSDB] A respiratory tract irritant; A severe skin and eye irritant; [MSDSonline] See Formaldehyde.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
1,3,5-Trioxane properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
1,3,5-Trioxane boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 114.5 °C (238.1 °F) | at 759 mmHg | HSDB |
1,3,5-Trioxane melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 64 °C (147.2 °F) | HSDB | |
| 63.89 °C (147 °F) | CAMEO |
1,3,5-Trioxane density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.17 g/cm³ | at 65 °C | HSDB |
1,3,5-Trioxane solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | SOL IN BENZENE, CARBON TETRACHLORIDE, CHLOROFORM, CARBON DISULFIDE | HSDB | |
| greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) | at 20 °C | CAMEO |
1,3,5-Trioxane vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 13 mmHg | at 25 °C | CAMEO |
| 13 mmHg | Haz-Map |
1,3,5-Trioxane flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 45 °C (113 °F) | HSDB |
1,3,5-Trioxane autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 413.89 °C (777 °F) | HSDB |
1,3,5-Trioxane lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 3.6 % by volume | CAMEO | |
| EXPLOSIVE LIMITS IN AIR 3.5-29%. | HSDB |
1,3,5-Trioxane upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 28.7 % by volume | CAMEO |
1,3,5-Trioxane vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 3.1 (air = 1) | CAMEO |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
1,3,5-Trioxane fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
1,3,5-Trioxane fire potential
MODERATE FIRE RISK.
Source: Hazardous Substances Data Bank (HSDB)
Solubility
SOL IN WATER: 17.2 G/100 ML @ 18 °C, 21.2 @ 25 °C; EASILY SOL IN ALC, KETONES, ETHER, ACETONE, ORG SOLVENTS, CHLORINATED & AROMATIC HYDROCARBONS; SLIGHTLY SOL IN PENTANE, PETROLEUM ETHER, LOWER PARAFFINS
Source: HSDB
10 · Handling and storage
1,3,5-Trioxane storage and handling
1,3,5-Trioxane peroxide formation
D*: Other compounds that may form peroxides
Source: Lab and Research Safety, University of Minnesota
1,3,5-Trioxane storage conditions
STORE IN COOL, DRY, WELL-VENTILATED PLACE AWAY FROM SOURCES OF HEAT & IGNITION. SEPARATE FROM COMBUSTIBLES, & ACIDIC, ALKALINE, & OXIDIZING MATERIALS. /PARAFORMALDEHYDE/
Source: Hazardous Substances Data Bank (HSDB)
1,3,5-Trioxane reactivity
1,3,5-TRIOXANE is stable under normal laboratory conditions but is unstable in the presence of acids, which initiate polymerization. Sublimes readily. May react with oxidizing matter (NTP, 1992). A stable polymeric product of formaldehyde that in the presence of strong aqueous acids will depolymerize (reforming the parent formaldehyde). Inert to strong alkalis. Readily converted in non aqueous solutions to the monomeric formaldehyde by small concentrations of acid---the rate of conversion is directly proportional to the concentration of the acid.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 1,3,5-Trioxane in the storage compatibility matrix →
11 · Questions
1,3,5-Trioxane — frequently asked questions
What is the CAS number of 1,3,5-Trioxane?
The CAS number of 1,3,5-Trioxane is 110-88-3. Its EC number is 203-812-5.
What is the chemical formula of 1,3,5-Trioxane?
The molecular formula of 1,3,5-Trioxane is C3H6O3 and its molecular weight is 90.08 g/mol.
What does a 1,3,5-Trioxane label have to show?
Under CLP Annex VI the label for 1,3,5-Trioxane carries the pictograms Flame, Health hazard and Exclamation mark and the signal word is Danger.
Is 1,3,5-Trioxane flammable?
Yes. CLP Annex VI assigns 1,3,5-Trioxane H228 — flammable solid. The flash point reported for it is 45 °C (113 °F) (HSDB).
Is 1,3,5-Trioxane a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 1,3,5-Trioxane. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of 1,3,5-Trioxane?
The boiling point reported for 1,3,5-Trioxane is 114.5 °C (238.1 °F), at 759 mmHg (HSDB).
What is the melting point of 1,3,5-Trioxane?
The melting point reported for 1,3,5-Trioxane is 64 °C (147.2 °F) (HSDB).
How should 1,3,5-Trioxane be stored?
STORE IN COOL, DRY, WELL-VENTILATED PLACE AWAY FROM SOURCES OF HEAT & IGNITION. SEPARATE FROM COMBUSTIBLES, & ACIDIC, ALKALINE, & OXIDIZING MATERIALS. /PARAFORMALDEHYDE/ (Hazardous Substances Data Bank (HSDB))
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