Substance profile
4-Methylpyridine
4-Methylpyridine is a colorless liquid with obnoxious, sweetish odor.
01 · Identification
What 4-Methylpyridine is
4-Methylpyridine is a colorless liquid with obnoxious, sweetish odor. Its molecular formula is C6H7N and its molecular weight is 93.13 g/mol. It boils at 145 °C, melts at 3.7 °C, is miscible with water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
4-Methylpyridine identifiers and molecular data
4-Methylpyridine CAS number and EC number
4-Methylpyridine molecular formula and molecular weight
Other names for 4-Methylpyridine
- 4-picoline
03 · GHS classification
4-Methylpyridine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4-Methylpyridine pictograms and signal word
4-Methylpyridine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Flammable liquids GHS chapter 2.6 | Category 3 | H226 | GHS02 |
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
4-Methylpyridine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H226 | Flammable liquid and vapour. |
| H311 | Toxic in contact with skin. |
| H332 | Harmful if inhaled. |
| H302 | Harmful if swallowed. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
This page lists only the codes assigned to 4-Methylpyridine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4-Methylpyridine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4-Methylpyridine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4-Methylpyridine precautionary statements
CLP Annex VI assigns 22 precautionary statements to 4-Methylpyridine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4-Methylpyridine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4-метилпиридин 4-пиколин |
| Spanish español | 4-Metilpiridina 4-picolina |
| Czech čeština | 4-methylpyridin γ-pikolin |
| Danish dansk | 4-methylpyridin 4-picolin |
| German Deutsch | 4-Methylpyridin 4-Picolin |
| Estonian eesti | 4-metüülpüridiin 4-pikoliin |
| Greek ελληνικά | 4-μεθυλοπυριδίνη 4-πικολίνη |
| English English | 4-methylpyridine 4-picoline |
| French français | 4-méthylpyridine 4-picoline |
| Croatian hrvatski | 4-metilpiridin 4-pikolin |
| Italian italiano | 4-metilpiridina 4-picolina |
| Latvian latviešu | 4-metilpiridīns 4-pikolīns |
| Lithuanian lietuvių | 4-metilpiridinas 4-pikolinas |
| Hungarian magyar | 4-metilpiridin 4-pikolin |
| Maltese Malti | 4-metilpiridina 4-pikolina |
| Dutch Nederlands | 4-methylpyridine 4-picoline |
| Polish polski | 4-metylopirydyna 4-pikolina |
| Portuguese português | 4-metilpiridina 4-picolina |
| Romanian română | 4- metilpiridină 4-picolină |
| Slovak slovenčina | 4-metylpyridín 4-pikolín |
| Slovenian slovenščina | 4-metilpiridin 4-pikolin |
| Finnish suomi | 4-pikoliini 4-metyylipyridin |
| Swedish svenska | 4-metylpyridin 4-pikolin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4-Methylpyridine GHS label elements
Everything CLP Annex VI fixes for 4-Methylpyridine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4-Methylpyridine
- Flammable liquid and vapour.
- Toxic in contact with skin.
- Harmful if inhaled.
- Harmful if swallowed.
- May cause respiratory irritation.
- Causes skin irritation.
- Causes serious eye irritation.
- Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Keep container tightly closed.
- Use explosion-proof [electrical/ventilating/lighting/…] equipment.
- Use only non-sparking tools.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Store in a well-ventilated place.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4-Methylpyridine in the GHS label constructor →
07 · Health hazards
4-Methylpyridine health hazards and exposure limits
4-Methylpyridine hazard summary
A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation of high concentrations can cause unconsciousness; The liquid defats the skin; [ICSC] An irritant; Can be absorbed through skin; [MSDSonline] An irritant that can cause CNS depression; Liver changes occur in rats exposed to chronic high doses; [AIHA] See Pyridine.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
4-Methylpyridine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4-Methylpyridine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 145 °C (293 °F) | at 760 mmHg | HSDB |
| 144.89 °C (292.8 °F) | at 760 mmHg | CAMEO | |
| 144.5 °C (292.1 °F) | range, midpoint shown | ICSC |
4-Methylpyridine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 3.68 °C (38.6 °F) | HSDB | |
| 3.61 °C (38.5 °F) | CAMEO | ||
| 3.7 °C (38.7 °F) | ICSC |
4-Methylpyridine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.96 g/cm³ | ICSC | |
| 0.9548 g/cm³ | at 20 °C | HSDB |
4-Methylpyridine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in alcohol, ether | HSDB | |
| Soluble in acetone, carbon tetrachloride | HSDB | ||
| Miscible with water at 20 °C | at 20 °C | HSDB |
4-Methylpyridine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 5.77 mmHg | at 25 °C | HSDB |
| 5.7005 mmHg | at 25 °C | ICSC | |
| 5.77 mmHg | Haz-Map |
4-Methylpyridine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 56.67 °C (134 °F) | HSDB | |
| 39 °C (102.2 °F) | HSDB |
4-Methylpyridine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.3 % by volume | ICSC |
4-Methylpyridine upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 8.7 % by volume | ICSC |
4-Methylpyridine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 3.2 (air = 1) | HSDB |
4-Methylpyridine critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 372.65 °C (702.8 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
4-Methylpyridine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
4-Methylpyridine fire potential
Moderate fire risk.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
4-Methylpyridine storage and handling
4-Methylpyridine safe storage
Fireproof. Separated from strong oxidants. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
4-Methylpyridine storage conditions
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Source: Hazardous Substances Data Bank (HSDB)
4-Methylpyridine incompatible materials
Incompatible materials: Oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
4-Methylpyridine reactivity
4-METHYL PYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-Methylpyridine in the storage compatibility matrix →
11 · Questions
4-Methylpyridine — frequently asked questions
What is the CAS number of 4-Methylpyridine?
The CAS number of 4-Methylpyridine is 108-89-4. Its EC number is 203-626-4.
What is the chemical formula of 4-Methylpyridine?
The molecular formula of 4-Methylpyridine is C6H7N and its molecular weight is 93.13 g/mol.
What does a 4-Methylpyridine label have to show?
Under CLP Annex VI the label for 4-Methylpyridine carries the pictograms Flame and Skull and crossbones and the signal word is Danger.
Is 4-Methylpyridine flammable?
Yes. CLP Annex VI assigns 4-Methylpyridine H226 — flammable liquid and vapour. The flash point reported for it is 56.67 °C (134 °F) (HSDB).
Is 4-Methylpyridine a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 4-Methylpyridine. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of 4-Methylpyridine?
The boiling point reported for 4-Methylpyridine is 145 °C (293 °F), at 760 mmHg (HSDB).
What is the melting point of 4-Methylpyridine?
The melting point reported for 4-Methylpyridine is 3.68 °C (38.6 °F) (HSDB).
How should 4-Methylpyridine be stored?
CLP Annex VI assigns 4-Methylpyridine the storage statement P403. Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. (Hazardous Substances Data Bank (HSDB))
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