Substance profile
4-Chlorophenyl Isocyanate
4-Chlorophenyl Isocyanate is colorless to slightly yellow liquid or crystals.
01 · Identification
What 4-Chlorophenyl Isocyanate is
4-Chlorophenyl Isocyanate is colorless to slightly yellow liquid or crystals. Its molecular formula is C7H4ClNO and its molecular weight is 153.56 g/mol. It boils at 204 °C, melts at 31.3 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
4-Chlorophenyl Isocyanate identifiers and molecular data
4-Chlorophenyl Isocyanate CAS number and EC number
4-Chlorophenyl Isocyanate molecular formula and molecular weight
Other names for 4-Chlorophenyl Isocyanate
- 4-chlorophenylisocyanate
03 · GHS classification
4-Chlorophenyl Isocyanate hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4-Chlorophenyl Isocyanate pictograms and signal word
4-Chlorophenyl Isocyanate hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 1 | H318 | GHS05 |
| Respiratory sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H334 | GHS08 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4-Chlorophenyl Isocyanate hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H330 | Fatal if inhaled. |
| H302 | Harmful if swallowed. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H318 | Causes serious eye damage. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 4-Chlorophenyl Isocyanate. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4-Chlorophenyl Isocyanate
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4-Chlorophenyl… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4-Chlorophenyl Isocyanate precautionary statements
CLP Annex VI assigns 25 precautionary statements to 4-Chlorophenyl Isocyanate. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4-Chlorophenyl Isocyanate name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4-хлорофенилизоцианат |
| Spanish español | Isocianato de 4-clorofenilo |
| Czech čeština | (4-chlorfenyl)isokyanát |
| Danish dansk | 4-chlorphenylisocyanat |
| German Deutsch | 4-Chlorphenylisocyanat |
| Estonian eesti | 4-klorofenüülisotsüanaat |
| Greek ελληνικά | ισοκυανικό 4-χλωροφαινύλιο |
| English English | 4-chlorophenylisocyanate |
| French français | 4-chlorophénylisocyanate |
| Croatian hrvatski | 4-klorfenilizocijanat |
| Italian italiano | isocianato di 4-clorofenile |
| Latvian latviešu | 4-hlorfenilizocianāts |
| Lithuanian lietuvių | 4-chlorfenilizocianatas |
| Hungarian magyar | 4-klórfenil-izocianát |
| Maltese Malti | 4-klorofenilisoċjanat |
| Dutch Nederlands | 4-chloorfenylisocyanaat |
| Polish polski | 4-chlorofenyloizocyjanian |
| Portuguese português | isocianato de 4-clorofenilo |
| Romanian română | 4-clorfenilizocianat |
| Slovak slovenčina | 4-chlórfenylizokyanát |
| Slovenian slovenščina | 4-klorofenil izocianat |
| Finnish suomi | 4-kloorifenyyli-isosyanaatti |
| Swedish svenska | 4-klorfenylisocyanat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4-Chlorophenyl Isocyanate GHS label elements
Everything CLP Annex VI fixes for 4-Chlorophenyl Isocyanate, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4-Chlorophenyl Isocyanate
- Fatal if inhaled.
- Harmful if swallowed.
- May cause respiratory irritation.
- Causes skin irritation.
- Causes serious eye damage.
- May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- [In case of inadequate ventilation] wear respiratory protection.
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Remove person to fresh air and keep comfortable for breathing.
- If experiencing respiratory symptoms:
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4-Chlorophenyl Isocyanate in the GHS label constructor →
07 · Health hazards
4-Chlorophenyl Isocyanate health hazards and exposure limits
4-Chlorophenyl Isocyanate hazard summary
A strong irritant of the skin and eyes; [Hawley] An irritant; May cause lacrimation and serious injury to eyes; May cause respiratory sensitization after prolonged contact; [MSDSonline] Could be carcinogenic for man but not conclusive because of insufficient data (3B); [MAK] See MONOISOCYANATES.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
4-Chlorophenyl Isocyanate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4-Chlorophenyl Isocyanate boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 204 °C (399.2 °F) | HSDB | |
| 116 °C (240.8 °F) | at 45 mmHg (reduced pressure) | HSDB |
4-Chlorophenyl Isocyanate melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 31.3 °C (88.3 °F) | HSDB |
4-Chlorophenyl Isocyanate density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.25 g/cm³ | at 40 °C | HSDB |
4-Chlorophenyl Isocyanate solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in organic solvents | HSDB |
4-Chlorophenyl Isocyanate vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 95.4 mmHg | at 20 °C | HSDB |
| 19.4 mmHg | at 25 °C, extrapolated | HSDB | |
| 95.4 mmHg | Haz-Map |
4-Chlorophenyl Isocyanate flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 110 °C (230 °F) | HSDB |
4-Chlorophenyl Isocyanate lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Can explode on distillation. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
4-Chlorophenyl Isocyanate fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
4-Chlorophenyl Isocyanate fire potential
A flammable liquid when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
4-Chlorophenyl Isocyanate storage and handling
4-Chlorophenyl Isocyanate storage conditions
Isocyanates are transported in railroad tank cars, tank trucks, tanks in ships, containers, and drums. They are stored in steel tanks and processed in steel equipment. For long-term storage stainless steel is recommended. To avoid contamination by atmospheric moisture, a dry air or inert gas blanket is essential. /Isocyanates/
Source: Hazardous Substances Data Bank (HSDB)
4-Chlorophenyl Isocyanate reactivity
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-Chlorophenyl Isocyanate in the storage compatibility matrix →
11 · Questions
4-Chlorophenyl Isocyanate — frequently asked questions
What is the CAS number of 4-Chlorophenyl Isocyanate?
The CAS number of 4-Chlorophenyl Isocyanate is 104-12-1. Its EC number is 203-176-9.
What is the chemical formula of 4-Chlorophenyl Isocyanate?
The molecular formula of 4-Chlorophenyl Isocyanate is C7H4ClNO and its molecular weight is 153.56 g/mol.
What does a 4-Chlorophenyl Isocyanate label have to show?
Under CLP Annex VI the label for 4-Chlorophenyl Isocyanate carries the pictograms Skull and crossbones, Corrosion, Health hazard and Environment and the signal word is Danger.
Is 4-Chlorophenyl Isocyanate flammable?
CLP Annex VI assigns 4-Chlorophenyl Isocyanate no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 110 °C (230 °F) (HSDB).
Is 4-Chlorophenyl Isocyanate a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 4-Chlorophenyl Isocyanate. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of 4-Chlorophenyl Isocyanate?
The boiling point reported for 4-Chlorophenyl Isocyanate is 204 °C (399.2 °F) (HSDB).
What is the melting point of 4-Chlorophenyl Isocyanate?
The melting point reported for 4-Chlorophenyl Isocyanate is 31.3 °C (88.3 °F) (HSDB).
How should 4-Chlorophenyl Isocyanate be stored?
Isocyanates are transported in railroad tank cars, tank trucks, tanks in ships, containers, and drums. They are stored in steel tanks and processed in steel equipment. For long-term storage stainless steel is recommended. To avoid contamination by atmospheric moisture, a dry air or inert gas blanket is essential. /Isocyanates/ (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to 4-Chlorophenyl Isocyanate
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