Substance profile
Ziram
Ziram is crystals from hot chloroform + alcohol and is odorless.
01 · Identification
What Ziram is
Ziram is crystals from hot chloroform + alcohol and is odorless. Its molecular formula is C6H12N2S4Zn and its molecular weight is 305.8 g/mol. It melts at 246 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Ziram identifiers and molecular data
Ziram CAS number and EC number
Ziram molecular formula and molecular weight
Other names for Ziram
- ziram (ISO)
- zinc bis dimethyldithiocarbamate
03 · GHS classification
Ziram hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Ziram pictograms and signal word
Ziram hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 1 | H318 | GHS05 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Specific target organ toxicity - single exposure GHS chapter 3.8 | Category 3 | H335 | GHS07 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Ziram hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H330 | Fatal if inhaled. |
| H302 | Harmful if swallowed. |
| H335 | May cause respiratory irritation. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H318 | Causes serious eye damage. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Ziram. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Ziram
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Ziram issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Ziram precautionary statements
CLP Annex VI assigns 19 precautionary statements to Ziram. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Ziram name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | цирам (ISO) цинков бисдиметилдитиокарбамат |
| Spanish español | Ziram (ISO) bisdimetilditiocarbamato de cinc |
| Czech čeština | ziram (ISO) bis( N, N -dimethyldithiokarbamát) zinečnatýzink- N, N -dimethyldithiokarbamát |
| Danish dansk | ziram (ISO) zink-bis( N, N- dimethyldithiocarbamat) |
| German Deutsch | Ziram (ISO) Zinkbis(dimethyl-dithiocarbamat) |
| Estonian eesti | tsiraam (ISO) tsinkbis(dimetüülditiokarbamaat) |
| Greek ελληνικά | ziram (ζιράμη) (ISO) δις(διμεθυλοδιθειoκαρβαμιδικός) ψευδάργυρος |
| English English | ziram (ISO) zinc bis dimethyldithiocarbamate |
| French français | zirame (ISO) bisdiméthyldithiocarbamate de zinc |
| Croatian hrvatski | ziram (ISO) cinkov bis-dimetil-ditiokarbamat |
| Italian italiano | ziram [ISO] bis(N, N-dimetil-ditiocarbammato) di zinco |
| Latvian latviešu | cirams (ISO) cinka bisdimetilditiokarbamāts |
| Lithuanian lietuvių | ziramas (ISO) cinko bis(N, N-dimetilditiokarbamatas) |
| Hungarian magyar | zirám (ISO) cink-bisz(dimetil-ditiokarbamát) |
| Maltese Malti | This edition prints another entry’s name as one of the designations here. The Maltese edition prints the dibutyl name of entry 006-081-00-9 as the second designation here. The first designation, żiram (ISO), is correct. CAS 137-30-4 in the same row is the dimethyl compound, and twenty-two of the twenty-three editions print the dimethyl name. Regulation (EU) 2018/669, OJ L 115, 4.5.2018, p. 11 żiram (ISO) bis(dibutilditijokarbamat) taż-żingu |
| Dutch Nederlands | ziram (ISO) zink-bis( N , N -dimethyldithiocarbamaat) |
| Polish polski | ziram (ISO) bis(dimetyloditiokarbaminian) cynku |
| Portuguese português | zirame (ISO) bis(dimetilditiocarbamato) de zinco |
| Romanian română | ziram (ISO) bis dimetilditiocarbamat de zinc |
| Slovak slovenčina | ziram (ISO) zinkium-bis(dimetylditiokarbamát) |
| Slovenian slovenščina | ziram (ISO) cinkov bis dimetilditiokarbamat |
| Finnish suomi | ziraami (ISO) sinkkibis(dimetyyliditiokarbamaatti) |
| Swedish svenska | ziram (ISO) zinkbisdimetylditiokarbamat |
One or more lines above are flagged. In those language editions the Regulation as published in the Official Journal prints something that the rest of the same row contradicts — a name belonging to a different entry, or the qualifier of a paired entry. Each flag cites the amending act and the Official Journal page, so the wording can be checked at source. The lines are reproduced as printed, because Art. 18(2) points at Annex VI and not at our reading of it; the note beside each one says what the row’s own EC and CAS numbers identify.
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Ziram GHS label elements
Everything CLP Annex VI fixes for Ziram, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Ziram
- Fatal if inhaled.
- Harmful if swallowed.
- May cause respiratory irritation.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes serious eye damage.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- If skin irritation or rash occurs:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Ziram in the GHS label constructor →
07 · Health hazards
Ziram health hazards and exposure limits
Ziram hazard summary
Allergic contact dermatitis reported in farmworkers; [Kanerva, p. 1847] Danger of skin sensitization; [MAK] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] A skin, respiratory tract, and severe eye irritant; May cause skin sensitization; Tumors observed in experimental animals with unknown relevance to humans; [ICSC] The primary target organs for toxicity seem to be the nervous system, liver, and thyroid; In rats a single oral dose can cause neurological impairment. Histopathology of the liver (sometimes with corresponding increases in hepatic serum enzyme levels) observed in sub-chronic and chronic rat studies and carcinogenicity study of mice; Classified as suggestive of carcinogenicity in humans; [Reference #2] See the agent, Ethylene thiourea.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Ziram carcinogenicity classification
Under the conditions of these studies, ziram was carcinogenic for male F344/N rats, causing increased incidences of C-cell carcinomas of the thyroid gland. Ziram was not carcinogenic for either female F344/N rats or for male B6C3F1 mice. Increased incidences of alveolar/bronchiolar adenomas and of combined alveolar/bronchiolar adenomas or carcinomas occurred in female B6C3F1 mice. However, the interpretation of this increase in lung tumors is complicated by an intercurrent Sendai virus infection.
Source: US National Toxicology Program · TR-238: Carcinogenesis Bioassay of Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study) (1983 )
Cancer Classification: Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential; Likely to be Carcinogenic to Humans
Source: Hazardous Substances Data Bank (HSDB)
Evaluation: No data were available from studies in humans. There is limited evidence in experimental animals for the carcinogenicity of ziram. Overall evaluation: Ziram is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Ziram properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Ziram melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 246 °C (474.8 °F) | HSDB | |
| 250 °C (482 °F) | crystals | HSDB | |
| 250 °C (482 °F) | CAMEO |
Ziram density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.7 g/cm³ | ICSC | |
| 1.66 g/cm³ | at 25 °C | HSDB |
Ziram solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in carbon disulfide, chloroform, dilute alkalies, and concentrated HCl. | HSDB | |
| Soluble in alkali. | HSDB |
Ziram vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 7.5e-9 mmHg | at 0 °C | HSDB |
| 1e-8 mmHg | Haz-Map | ||
| Negligible (NTP, 1992) | CAMEO |
Ziram flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 93.33 °C (200 °F) | CAMEO |
Ziram corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | NONCORROSIVE EXCEPT TO IRON & COPPER | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Ziram fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Ziram fire potential
CAN FORM FLAMMABLE DUST.
Source: Hazardous Substances Data Bank (HSDB)
Solubility
In alcohol: less than 0.2 g/100 ml @ 25 °C; in acetone: less than 0.5 g/100 ml @ 25 °C; in benzene: less than 0.5 g/100 ml @ 25 °C; in carbon tetrachloride: less than 0.2 g/100 ml @ 25 °C; in ether: less than 0.2 g/100 ml @ 25 °C; in naphtha: 0.5 g/100 ml @ 25 °C. sol in diluted caustic soln.
Source: HSDB
10 · Handling and storage
Ziram storage and handling
Ziram safe storage
Store in an area without drain or sewer access. Separated from acids and food and feedstuffs. Keep in a well-ventilated room. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Ziram storage conditions
Mezene must be stored in its sealed original containers, in well-aired, fresh & dry storehouses or in shaded & possibly well-aired places. It is recommended that the product's temp not exceed 25-30 °C. Container must be stacked in such a way to permit free circulation of air also at bottom & inside of piles.
Source: Hazardous Substances Data Bank (HSDB)
Ziram incompatible materials
... Incompatable with compounds containing iron, copper, mercury, TEPP, lime, & calcium arsenate.
Source: Hazardous Substances Data Bank (HSDB)
Ziram reactivity
ZIRAM is a dithiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides. ZIRAM is corrosive to iron and copper. It is incompatible with strong oxidizing agents and acids. It is also incompatible with mercury. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Ziram in the storage compatibility matrix →
11 · Questions
Ziram — frequently asked questions
What is the CAS number of Ziram?
The CAS number of Ziram is 137-30-4. Its EC number is 205-288-3.
What is the chemical formula of Ziram?
The molecular formula of Ziram is C6H12N2S4Zn and its molecular weight is 305.8 g/mol.
What does a Ziram label have to show?
Under CLP Annex VI the label for Ziram carries the pictograms Skull and crossbones, Health hazard, Corrosion and Environment and the signal word is Danger.
Is Ziram flammable?
CLP Annex VI assigns Ziram no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 93.33 °C (200 °F) (CAMEO).
Is Ziram a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Ziram. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the melting point of Ziram?
The melting point reported for Ziram is 246 °C (474.8 °F) (HSDB).
How should Ziram be stored?
Mezene must be stored in its sealed original containers, in well-aired, fresh & dry storehouses or in shaded & possibly well-aired places. It is recommended that the product's temp not exceed 25-30 °C. Container must be stacked in such a way to permit free circulation of air also at bottom & inside of piles. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Ziram
Keep going: substances starting with Z, or search the whole database by name, CAS number, pictogram or signal word.