Substance profile
2-Nitroanisole
2-Nitroanisole is a colorless to yellowish liquid.
01 · Identification
What 2-Nitroanisole is
2-Nitroanisole is a colorless to yellowish liquid. Its molecular formula is C7H7NO3 and its molecular weight is 153.14 g/mol. It boils at 277 °C, melts at 10.5 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
2-Nitroanisole identifiers and molecular data
2-Nitroanisole CAS number and EC number
2-Nitroanisole molecular formula and molecular weight
03 · GHS classification
2-Nitroanisole hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
2-Nitroanisole pictograms and signal word
2-Nitroanisole hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
2-Nitroanisole hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
This page lists only the codes assigned to 2-Nitroanisole. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 2-Nitroanisole
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 2-Nitroanisole issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
2-Nitroanisole precautionary statements
CLP Annex VI assigns 8 precautionary statements to 2-Nitroanisole. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
2-Nitroanisole name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2-нитроанизол |
| Spanish español | 2-Nitroanisol |
| Czech čeština | 1-methoxy-2-nitrobenzen |
| Danish dansk | 2-nitroanisol |
| German Deutsch | 2-Nitroanisol 2-Methoxynitrobenzol |
| Estonian eesti | 2-nitroanisool |
| Greek ελληνικά | 2-νιτροανισόλη |
| English English | 2-nitroanisole |
| French français | 2-nitroanisole |
| Croatian hrvatski | 2-nitroanisol |
| Italian italiano | 2-nitroanisolo |
| Latvian latviešu | 2-nitroanizols |
| Lithuanian lietuvių | 2-nitroanizolas |
| Hungarian magyar | 2-nitroanizol |
| Maltese Malti | 2-nitroanisol |
| Dutch Nederlands | 2-nitroanisool |
| Polish polski | 2-nitroanizol |
| Portuguese português | 2-nitroanisole |
| Romanian română | 2-nitroanisol |
| Slovak slovenčina | 2-nitroanizol |
| Slovenian slovenščina | 2-nitroanizol |
| Finnish suomi | 2-nitroanisoli |
| Swedish svenska | 2-nitroanisol |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
2-Nitroanisole GHS label elements
Everything CLP Annex VI fixes for 2-Nitroanisole, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
2-Nitroanisole
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 2-Nitroanisole in the GHS label constructor →
07 · Health hazards
2-Nitroanisole health hazards and exposure limits
2-Nitroanisole hazard summary
Inhalation of high concentrations can cause methemoglobinemia; The substance may have effects on the blood, resulting in anaemia. [ICSC] An irritant; Effects in high-dose animal studies include methemoglobinemia; [MSDSonline] See 2021 (Volume 127) monograph at IARC.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
2-Nitroanisole carcinogenicity classification
Under the conditions of these feed studies there was clear evidence of carcinogenic activity of o-nitroanisole in male and female F344 rats that received diets containing 6,000 or 18,000 ppm for 6 months based on overall increased incidences of benign and malignant neoplasms of the urinary bladder, transitional cell neoplasms of the kidney, and benign and malignant neoplasms of the large intestine. There was a chemical-related increased incidence of mononuclear cell leukemia in male and female rats receiving diets containing 222, 666, or 2,000 ppm o-nitroanisole for 2 years. Marginally increased incidences of uncommon renal tubule neoplasms in male rats and forestomach neoplasms in male and female rats were considered uncertain findings. There was clear evidence of carcinogenic activity of o-nitroanisolein male B6C3F1 mice based on increased incidences of benign and malignant hepatocellular neoplasms. There was some evidence of carcinogenic activity of o-nitroanisole in female B6C3F1 mice based on increased incidences of hepatocellular adenomas.
Source: US National Toxicology Program · TR-416: Toxicology and Carcinogenesis Studies of o-Nitroanisole (CASRN 91-23-6) in F344 Rats and B6C3F1 Mice (Feed Studies) (1993 )
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2-nitroanisole. There is sufficient evidence in experimental animals for the carcinogenicity of 2-nitroanisole. Overall evaluation: 2-Nitroanisole is possibly carcinogenic to humans (Group 2B).
Source: Hazardous Substances Data Bank (HSDB)
o-Nitroanisole: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
2-Nitroanisole properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
2-Nitroanisole boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 277 °C (530.6 °F) | ICSC | |
| 269.5 °C (517.1 °F) | range, midpoint shown | HSDB | |
| 277 °C (530.6 °F) | at 4 mmHg (reduced pressure) | HSDB |
2-Nitroanisole melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 10.5 °C (50.9 °F) | HSDB |
2-Nitroanisole density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.254 g/cm³ | at 20 °C | HSDB |
| 1.25 g/cm³ | at 20 °C | ICSC |
2-Nitroanisole solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Miscible with ethanol, ethyl ether; soluble in carbon tetrachloride | HSDB | |
| In water, 1.69X10+3 mg/L at 30 °C | at 30 °C | HSDB | |
| Solubility in water, g/l at 30 °C: 1.69 (slightly soluble) | at 30 °C | ICSC |
2-Nitroanisole vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0036 mmHg | at 25 °C | HSDB |
| 0.03 mmHg | at 30 °C | ICSC | |
| 0.0036 mmHg | Haz-Map |
2-Nitroanisole flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 142 °C (287.6 °F) | HSDB | |
| 124 °C (255.2 °F) | Haz-Map |
2-Nitroanisole autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 464 °C (867.2 °F) | HSDB |
2-Nitroanisole lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.04 % by volume | at 150 °C | ICSC |
| The explosion of 400 g of o-nitroanisole during reduction using nickel as a catalyst has been reported. | HSDB | ||
| Catalytic hydrogenation of nitroanisole in the presence of nickel catalyst has resulted in an explosion. | HSDB |
2-Nitroanisole upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 66 % by volume | at 150 °C | ICSC |
2-Nitroanisole vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 5.29 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
2-Nitroanisole storage and handling
2-Nitroanisole safe storage
Well closed. Store only in original packaging. Ventilation along the floor. Dry.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
2-Nitroanisole storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check 2-Nitroanisole in the storage compatibility matrix →
10 · Questions
2-Nitroanisole — frequently asked questions
What is the CAS number of 2-Nitroanisole?
The CAS number of 2-Nitroanisole is 91-23-6. Its EC number is 202-052-1.
What is the chemical formula of 2-Nitroanisole?
The molecular formula of 2-Nitroanisole is C7H7NO3 and its molecular weight is 153.14 g/mol.
What does a 2-Nitroanisole label have to show?
Under CLP Annex VI the label for 2-Nitroanisole carries the pictograms Health hazard and Exclamation mark and the signal word is Danger.
Is 2-Nitroanisole flammable?
CLP Annex VI assigns 2-Nitroanisole no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 142 °C (287.6 °F) (HSDB).
Is 2-Nitroanisole a carcinogen?
Yes. CLP Annex VI classifies 2-Nitroanisole as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2A: probably carcinogenic to humans.
What is the boiling point of 2-Nitroanisole?
The boiling point reported for 2-Nitroanisole is 277 °C (530.6 °F) (ICSC).
What is the melting point of 2-Nitroanisole?
The melting point reported for 2-Nitroanisole is 10.5 °C (50.9 °F) (HSDB).
How should 2-Nitroanisole be stored?
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. (Hazardous Substances Data Bank (HSDB))
Nearby
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