Substance profile
6-methoxy-m-toluidine
6-methoxy-m-toluidine is white crystals.
01 · Identification
What 6-methoxy-m-toluidine is
6-methoxy-m-toluidine is white crystals. Its molecular formula is C8H11NO and its molecular weight is 137.18 g/mol. It boils at 235 °C, melts at 51.5 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
6-methoxy-m-toluidine identifiers and molecular data
6-methoxy-m-toluidine CAS number and EC number
6-methoxy-m-toluidine molecular formula and molecular weight
Other names for 6-methoxy-m-toluidine
- p-cresidine
03 · GHS classification
6-methoxy-m-toluidine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
6-methoxy-m-toluidine pictograms and signal word
6-methoxy-m-toluidine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
6-methoxy-m-toluidine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
This page lists only the codes assigned to 6-methoxy-m-toluidine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 6-methoxy-m-toluidine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 6-methoxy-m-toluidine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
6-methoxy-m-toluidine precautionary statements
CLP Annex VI assigns 8 precautionary statements to 6-methoxy-m-toluidine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
6-methoxy-m-toluidine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 6-метокси- m -толуидин p -крезидин |
| Spanish español | 6-Metoxi- m -toluidina p -cresidina |
| Czech čeština | 2-methoxy-5-methylanilin p -kresidin |
| Danish dansk | 6-methoxy- m -toluidin p -cresidin |
| German Deutsch | 6-Methoxy-m-toluidin p-Cresidin2-Methoxy-5-methylanilin |
| Estonian eesti | 6-metoksü- m -toluidiin p -kresidiin |
| Greek ελληνικά | 6-μεθοξυ- m -τολουιδίνη p -κρεσιδίνη |
| English English | 6-methoxy- m -toluidine p -cresidine |
| French français | 6-méthoxy- m -toluidine p -crésidine |
| Croatian hrvatski | 6-metoksi- m -toluidin p -krezidin |
| Italian italiano | 6-metossi- m -toluidina p -cresidina |
| Latvian latviešu | 6-metoksi- m -toluidīns p -krezidīns |
| Lithuanian lietuvių | 6-metoksi- m -toluidinas p -krezidinas |
| Hungarian magyar | 6-metoxi- m -toluidin p -krezidin |
| Maltese Malti | 6-metossi- m -toluwidina p -kresidina |
| Dutch Nederlands | 6-methoxy- m -toluïdine p -cresidine |
| Polish polski | 6-metoksy-m-toluidyna p -krezydyna3-amino-4-metoksytoluen |
| Portuguese português | 6-metoxi- m -toluidina p -cresidina |
| Romanian română | 6-metoxi- m -toluidină p -cresidină |
| Slovak slovenčina | 2-metoxy-5-metylanilín para -krezidín |
| Slovenian slovenščina | 6-metoksi- m -toluidin p -krezidin |
| Finnish suomi | 6-metoksi- m -toluidiini p -kresidiini |
| Swedish svenska | 6-metoxi- m -toluidin p -kresidin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
6-methoxy-m-toluidine GHS label elements
Everything CLP Annex VI fixes for 6-methoxy-m-toluidine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
6-methoxy-m-toluidine
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 6-methoxy-m-toluidine in the GHS label constructor →
07 · Health hazards
6-methoxy-m-toluidine health hazards and exposure limits
6-methoxy-m-toluidine hazard summary
Possibly carcinogenic to humans; [ICSC] Irritating to the skin and eyes; [HSDB] Harmful by ingestion, inhalation, and skin absorption; Can cause methemoglobinemia, damage to the liver, and unconsciousness; [CAMEO] An eye irritant; May induce methemoglobinemia; Targets blood, liver, and bladder; [MSDSonline]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
6-methoxy-m-toluidine carcinogenicity classification
Under the conditions of this bioassay, p-cresidine was carcinogenic to Fischer 344 rats, causing increased incidences of carcinomas and of papillomas of the urinary bladder in both sexes, increased incidences of olfactory neuroblastomas in both sexes, and of liver tumors in males. p-Cresidine was also carcinogenic in B6C3F1 mice, causing carcinomas of the urinary bladders in both sexes and hepatocellular carcinomas in females.
Source: US National Toxicology Program · TR-142: Bioassay of p-Cresidine for Possible Carcinogenicity (CASRN 120-71-8) (1979 )
Classification of carcinogenicity: 1) evidence in humans: no data; 2) evidence in animals: sufficient. Overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. /From table/
Source: Hazardous Substances Data Bank (HSDB)
p-Cresidine: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
6-methoxy-m-toluidine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
6-methoxy-m-toluidine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 235 °C (455 °F) | HSDB | |
| 235 °C (455 °F) | at 760 mmHg | CAMEO |
6-methoxy-m-toluidine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 51.5 °C (124.7 °F) | HSDB | |
| 53.06 °C (127.5 °F) | range, midpoint shown | CAMEO |
6-methoxy-m-toluidine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1 g/cm³ | CAMEO |
6-methoxy-m-toluidine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in water, chloroform. Soluble in ether, benzene, petroleum ether, and ethanol. | HSDB | |
| Solubility in water: poor | ICSC | ||
| less than 1 mg/mL at 72 °F (NTP, 1992) | at 22.22 °C | CAMEO |
6-methoxy-m-toluidine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0105 mmHg | at 25 °C | ICSC |
| 0.02 mmHg | Haz-Map |
6-methoxy-m-toluidine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 111 °C (231.8 °F) | ICSC | |
| 110 °C (230 °F) | above this value | CAMEO |
6-methoxy-m-toluidine autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 450 °C (842 °F) | ICSC |
6-methoxy-m-toluidine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.7 (air = 1) | calculated | CAMEO |
6-methoxy-m-toluidine corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | Liquid anisidine will attack some forms of plastics, rubber, and coatings. | o-Anisidine | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
6-methoxy-m-toluidine storage and handling
6-methoxy-m-toluidine safe storage
Separated from strong oxidants and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
6-methoxy-m-toluidine storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
6-methoxy-m-toluidine incompatible materials
Contact with strong oxidizers may cause fires and explosions. /o-Anisidine/
Source: Hazardous Substances Data Bank (HSDB)
6-methoxy-m-toluidine reactivity
P-CRESIDINE is sensitive to moisture and temperatures greater than 104 °F. Incompatible with strong oxidizing agents (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 6-methoxy-m-toluidine in the storage compatibility matrix →
10 · Questions
6-methoxy-m-toluidine — frequently asked questions
What is the CAS number of 6-methoxy-m-toluidine?
The CAS number of 6-methoxy-m-toluidine is 120-71-8. Its EC number is 204-419-1.
What is the chemical formula of 6-methoxy-m-toluidine?
The molecular formula of 6-methoxy-m-toluidine is C8H11NO and its molecular weight is 137.18 g/mol.
What does a 6-methoxy-m-toluidine label have to show?
Under CLP Annex VI the label for 6-methoxy-m-toluidine carries the pictograms Health hazard and Exclamation mark and the signal word is Danger.
Is 6-methoxy-m-toluidine flammable?
CLP Annex VI assigns 6-methoxy-m-toluidine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 111 °C (231.8 °F) (ICSC).
Is 6-methoxy-m-toluidine a carcinogen?
Yes. CLP Annex VI classifies 6-methoxy-m-toluidine as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of 6-methoxy-m-toluidine?
The boiling point reported for 6-methoxy-m-toluidine is 235 °C (455 °F) (HSDB).
What is the melting point of 6-methoxy-m-toluidine?
The melting point reported for 6-methoxy-m-toluidine is 51.5 °C (124.7 °F) (HSDB).
How should 6-methoxy-m-toluidine be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to 6-methoxy-m-toluidine
Keep going: substances starting with 0–9, or search the whole database by name, CAS number, pictogram or signal word.