Substance profile
Acetamide
Acetamide is deliquescent hexagonal crystals and is odorless.
01 · Identification
What Acetamide is
Acetamide is deliquescent hexagonal crystals and is odorless. Its molecular formula is C2H5NO and its molecular weight is 59.07 g/mol. It boils at 222 °C, melts at 81.2 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
Acetamide identifiers and molecular data
Acetamide CAS number and EC number
Acetamide molecular formula and molecular weight
03 · GHS classification
Acetamide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Acetamide pictograms and signal word
Acetamide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
Acetamide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
This page lists only the codes assigned to Acetamide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Acetamide
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Acetamide issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Acetamide precautionary statements
CLP Annex VI assigns 4 precautionary statements to Acetamide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Acetamide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | ацетамид |
| Spanish español | Acetamida |
| Czech čeština | acetamid |
| Danish dansk | acetamid |
| German Deutsch | Acetamid Essigsäureamid |
| Estonian eesti | atseetamiid |
| Greek ελληνικά | ακεταμίδιο |
| English English | acetamide |
| French français | acétamide |
| Croatian hrvatski | acetamid |
| Italian italiano | acetammide |
| Latvian latviešu | acetamīds |
| Lithuanian lietuvių | acetamidas |
| Hungarian magyar | acetamid |
| Maltese Malti | aċetammid |
| Dutch Nederlands | aceetamide |
| Polish polski | acetamid |
| Portuguese português | acetamida |
| Romanian română | acetamidă |
| Slovak slovenčina | acetamid |
| Slovenian slovenščina | acetamid |
| Finnish suomi | asetamidi |
| Swedish svenska | acetamid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Acetamide GHS label elements
Everything CLP Annex VI fixes for Acetamide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Acetamide
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Obtain special instructions before use.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Acetamide in the GHS label constructor →
07 · Health hazards
Acetamide health hazards and exposure limits
Acetamide hazard summary
Acetamide is used primarily as a solvent and a plasticizer. Workers may be exposed in the plastics and chemical industries. It causes mild skin irritation from acute (short-term) exposure. No information is available on the chronic (long-term), reproductive/developmental, or carcinogenic effects of acetamide in humans. EPA has not classified acetamide for carcinogenicity.
Source: EPA Hazardous Air Pollutants
Acetamide carcinogenicity classification
Cancer classification: Group C - possible human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
Evaluation: No epidemiological data relevant to the carcinogenicity of acetamide were available. There is sufficient evidence in experimental animals for the carcinogenicity of acetamide. Overall evaluation: Acetamide is possibly carcinogenic to humans (Group 2B).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Acetamide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Acetamide boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 222 °C (431.6 °F) | at 760 mmHg | HSDB |
| 221.11 °C (430 °F) | at 760 mmHg | CAMEO | |
| 222 °C (431.6 °F) | ICSC |
Acetamide melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 81.16 °C (178.1 °F) | HSDB | |
| 82.28 °C (180.1 °F) | CAMEO | ||
| 81 °C (177.8 °F) | ICSC |
Acetamide density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.16 g/cm³ | ICSC | |
| 1.159 g/cm³ | at 20 °C | HSDB |
Acetamide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | One gram dissolves in 0.5 mL water, 2 mL alcohol, 6 mL pyridine | HSDB | |
| Soluble in chloroform, glycerol, hot benzene | HSDB | ||
| In water, 7.05X10+5 mg/L at 24.5 °C | at 24.5 °C | HSDB |
Acetamide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0182 mmHg | at 25 °C | HSDB |
| 1 mmHg | at 60 °C | DOE PAC | |
| 1 mmHg | at 65 °C | CAMEO |
Acetamide odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Recognition: 140-160 mg/cu m | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Acetamide fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Acetamide fire potential
This substance is a combustible solid.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Acetamide storage and handling
Acetamide safe storage
Dry. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Acetamide storage conditions
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive.
Source: Hazardous Substances Data Bank (HSDB)
Acetamide incompatible materials
Incompatible materials: Strong oxidizing agents, strong acids, strong bases, strong reducing agents.
Source: Hazardous Substances Data Bank (HSDB)
Acetamide reactivity
ACETAMIDE may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Acetamide in the storage compatibility matrix →
11 · Questions
Acetamide — frequently asked questions
What is the CAS number of Acetamide?
The CAS number of Acetamide is 60-35-5. Its EC number is 200-473-5.
What is the chemical formula of Acetamide?
The molecular formula of Acetamide is C2H5NO and its molecular weight is 59.07 g/mol.
What does a Acetamide label have to show?
Under CLP Annex VI the label for Acetamide carries the pictogram Health hazard and the signal word is Warning.
Is Acetamide flammable?
CLP Annex VI assigns Acetamide no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Acetamide a carcinogen?
CLP Annex VI assigns Acetamide H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of Acetamide?
The boiling point reported for Acetamide is 222 °C (431.6 °F), at 760 mmHg (HSDB).
What is the melting point of Acetamide?
The melting point reported for Acetamide is 81.16 °C (178.1 °F) (HSDB).
How should Acetamide be stored?
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Acetamide
Keep going: substances starting with A, or search the whole database by name, CAS number, pictogram or signal word.