Substance profile
Cyclohexanone
Cyclohexanone is an oily liquid with an odor reminiscent of peppermint & acetone.
01 · Identification
What Cyclohexanone is
Cyclohexanone is an oily liquid with an odor reminiscent of peppermint & acetone. Its molecular formula is C6H10O and its molecular weight is 98.14 g/mol. It boils at 156 °C, melts at -31 °C.
Under the GHS it carries the signal word Warning. It is classed as flammable agents - 2nd degree.
02 · Identifiers
Cyclohexanone identifiers and molecular data
Cyclohexanone CAS number and EC number
Cyclohexanone molecular formula and molecular weight
03 · GHS classification
Cyclohexanone hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Cyclohexanone pictograms and signal word
Cyclohexanone hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Flammable liquids GHS chapter 2.6 | Category 3 | H226 | GHS02 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
Cyclohexanone hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H226 | Flammable liquid and vapour. |
| H332 | Harmful if inhaled. |
This page lists only the codes assigned to Cyclohexanone. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Cyclohexanone
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Cyclohexanone issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Cyclohexanone precautionary statements
CLP Annex VI assigns 9 precautionary statements to Cyclohexanone. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Cyclohexanone name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | циклохексанон |
| Spanish español | Ciclohexanona |
| Czech čeština | cyklohexanon |
| Danish dansk | cyclohexanon |
| German Deutsch | Cyclohexanon |
| Estonian eesti | tsükloheksanoon |
| Greek ελληνικά | κυκλοεξανόνη |
| English English | cyclohexanone |
| French français | cyclohexanone |
| Croatian hrvatski | cikloheksanon |
| Italian italiano | cicloesanone |
| Latvian latviešu | cikloheksanons |
| Lithuanian lietuvių | cikloheksanonas |
| Hungarian magyar | ciklohexanon |
| Maltese Malti | ċikloessanon |
| Dutch Nederlands | cyclohexanon |
| Polish polski | cykloheksanon |
| Portuguese português | ciclo-hexanona |
| Romanian română | ciclohexanonă |
| Slovak slovenčina | cyklohexanón |
| Slovenian slovenščina | cikloheksanon |
| Finnish suomi | sykloheksanoni |
| Swedish svenska | cyklohexanon |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Cyclohexanone GHS label elements
Everything CLP Annex VI fixes for Cyclohexanone, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Cyclohexanone
- Flammable liquid and vapour.
- Harmful if inhaled.
- Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Keep container tightly closed.
- Use explosion-proof [electrical/ventilating/lighting/…] equipment.
- Use only non-sparking tools.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Use only outdoors or in a well-ventilated area.
- IF INHALED:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Store in a well-ventilated place.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Cyclohexanone in the GHS label constructor →
07 · Health hazards
Cyclohexanone health hazards and exposure limits
Cyclohexanone hazard summary
Liquid causes first degree burns on short exposure; [CHRIS] Animals become stuporous in high-dose inhalation studies and develop liver necrosis after high-dose feeding studies. [ACGIH] [Sanmartin O, et al. Occupational contact dermatitis from cyclohexanone as a PVC adhesive. Contact Dermatitis. 1992 Sep;27(3):189-90. No abstract available. Abstract in NIOSHTIC #179644]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Cyclohexanone carcinogenicity classification
Evaluation: No epidemiological data relevant to the carcinogenicity of cyclohexanone were available. There is inadequate evidence in experimental animals for the carcinogenicity of cyclohexanone. Overall evaluation: Cyclohexanone is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Cyclohexanone occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 50.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 50 ppm (200 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 50 ppm (200 mg/m3) See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 25 ppm (100 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 25 ppm (100 mg/m3) [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 700 ppm (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 700.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | Excerpts from Documentation for IDLHs: It has been reported that exposure to 75 ppm for 3 to 5 minutes has resulted in pronounced irritation of the eyes, nose, and throat [Nelson et al. 1943]. | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Cyclohexanone properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Cyclohexanone boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 155.6 °C (312.1 °F) | at 760 mmHg | HSDB |
| 155.56 °C (312 °F) | NIOSH | ||
| 155.61 °C (312.1 °F) | at 760 mmHg | CAMEO |
Cyclohexanone melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -31 °C (-23.8 °F) | HSDB | |
| -45 °C (-49 °F) | NIOSH | ||
| -16.11 °C (3 °F) | CAMEO |
Cyclohexanone density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.95 g/cm³ | NIOSH | |
| 0.945 g/cm³ | at 20 °C | CAMEO | |
| 0.9421 g/cm³ | at 25 °C | HSDB |
Cyclohexanone solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | SOL IN ACETONE; ETHYL ETHER; ETHANOL; WATER | HSDB | |
| SOLUBLE IN ALCOHOL, ETHER, AND OTHER COMMON ORGANIC SOLVENTS | HSDB | ||
| SOLUBILITY OF WATER IN CYCLOHEXANONE: 87 G/L AT 20 °C. | at 20 °C | HSDB |
Cyclohexanone vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 5 mmHg | NIOSH | |
| 5.2 mmHg | at 25 °C | CAMEO | |
| 5 mmHg | at 26.4 °C | HSDB |
Cyclohexanone flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 43.89 °C (111 °F) | HSDB |
Cyclohexanone autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 420 °C (788 °F) | HSDB |
Cyclohexanone lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.2 % by volume | CAMEO | |
| 1.1 % by volume | OSHA |
Cyclohexanone upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 9.4 % by volume | NIOSH | |
| 8.1 % by volume | CAMEO |
Cyclohexanone vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 3.4 (air = 1) | HSDB |
Cyclohexanone odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | 0.88 ppm; v/v | HSDB | |
| Odor low mg/cu m= 0.4800; Odor high 400 mg/cu m; Irritating Concn= 100 mg/cu m | HSDB | ||
| Odor Threshold Low: 0.12 [ppm] | Haz-Map |
Cyclohexanone critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 356.11 °C (673 °F) | HSDB |
Cyclohexanone corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | Corrosive | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Cyclohexanone fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Cyclohexanone fire potential
MODERATE, WHEN EXPOSED TO HEAT OR FLAME; CAN REACT VIGOROUSLY WITH OXIDIZING MATERIALS ...
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Cyclohexanone storage and handling
Cyclohexanone peroxide formation
D*: Other compounds that may form peroxides
Source: Lab and Research Safety, University of Minnesota
Cyclohexanone safe storage
Fireproof. Separated from strong oxidants.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Cyclohexanone storage conditions
Keep containers closed; prohibit open flame. Store in cool and dark plane.
Source: Hazardous Substances Data Bank (HSDB)
Cyclohexanone incompatible materials
Incompatible with oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
Cyclohexanone reactivity
CYCLOHEXANONE forms an explosive peroxide with H2O2, and reacts vigorously with oxidizing materials (nitric acid). (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Cyclohexanone in the storage compatibility matrix →
11 · Transport
Cyclohexanone UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
Cyclohexanone under UN 1915 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| CYCLOHEXANONE | 3 | F1 | III | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 3 is “Flammable liquids” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Cyclohexanone | 3 | III | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 3 is “Flammable and combustible liquid” (49 CFR 173.2).
12 · Questions
Cyclohexanone — frequently asked questions
What is the CAS number of Cyclohexanone?
The CAS number of Cyclohexanone is 108-94-1. Its EC number is 203-631-1.
What is the chemical formula of Cyclohexanone?
The molecular formula of Cyclohexanone is C6H10O and its molecular weight is 98.14 g/mol.
What does a Cyclohexanone label have to show?
Under CLP Annex VI the label for Cyclohexanone carries the pictograms Flame and Exclamation mark and the signal word is Warning.
Is Cyclohexanone flammable?
Yes. CLP Annex VI assigns Cyclohexanone H226 — flammable liquid and vapour. The flash point reported for it is 43.89 °C (111 °F) (HSDB).
Is Cyclohexanone a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Cyclohexanone. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the exposure limit for Cyclohexanone?
The US occupational exposure limit reported for Cyclohexanone is 50.0 [ppm] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Cyclohexanone?
The boiling point reported for Cyclohexanone is 155.6 °C (312.1 °F), at 760 mmHg (HSDB).
What is the melting point of Cyclohexanone?
The melting point reported for Cyclohexanone is -31 °C (-23.8 °F) (HSDB).
How should Cyclohexanone be stored?
CLP Annex VI assigns Cyclohexanone the storage statement P403. Keep containers closed; prohibit open flame. Store in cool and dark plane. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Cyclohexanone
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