Substance profile
Cycloheximide
Cycloheximide is plates from amyl acetate, water or 30% methanol.
01 · Identification
What Cycloheximide is
Cycloheximide is plates from amyl acetate, water or 30% methanol. It melts at 25 °C.
Under the GHS it carries the signal word Danger. It is classed as teratogens.
02 · Identifiers
Cycloheximide identifiers and molecular data
Cycloheximide CAS number and EC number
Cycloheximide molecular formula and molecular weight
Other names for Cycloheximide
- cycloheximide (ISO)
- 4-{}{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}}piperidine-2,6-dione
03 · GHS classification
Cycloheximide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Cycloheximide pictograms and signal word
Cycloheximide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 1 or 2 | H300 | GHS06 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Cycloheximide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H360D | May damage the unborn child. |
| H300 | Fatal if swallowed. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Cycloheximide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Cycloheximide
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Cycloheximide issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Cycloheximide precautionary statements
CLP Annex VI assigns 11 precautionary statements to Cycloheximide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Cycloheximide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | циклохексимид (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-диметил-2-оксоциклохексил]-2-хидроксиетил}пиперидин-2,6-дион |
| Spanish español | Cicloheximida (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oxociclohexil]-2-hidroxietil}piperidina-2,6- diona |
| Czech čeština | cykloheximid (ISO) 4-[2-(3,5-dimethyl-2-oxocyklohexyl)-2-hydroxyethyl]piperidin-2,6-dion |
| Danish dansk | cycloheximid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidin-2,6-dion |
| German Deutsch | Cycloheximid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidin-2,6-dion |
| Estonian eesti | tsükloheksimiid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetüül-2-oksotsükloheksüül]-2-hüdroksüetüül}piperidiin-2,6-dioon |
| Greek ελληνικά | cycloheximide (κυκλοεξιμίδη) (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-διμεθυλ-2-οξοκυκλοεξυλ]-2-υδροξυαιθυλο}πιπεριδινο-2,6-διόνη |
| English English | cycloheximide (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5- dimethyl-2-oxocyclohexyl]-2- hydroxyethyl}piperidine-2,6- dione |
| French français | cycloheximide (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-diméthyl-2-oxocyclohexyl]-2-hydroxyéthyl}pipéridine-2,6-dione |
| Croatian hrvatski | cikloheksimid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oksocikloheksil]-2-hidroksietil}piperidin-2,6-dion |
| Italian italiano | cicloesimide (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5- dimetil-2-ossocicloesil]-2-idrossietil}piperidina-2,6- dione |
| Latvian latviešu | cikloheksimīds (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oksocikloheksil]-2-hidroksietil}piperidīn-2,6- dions |
| Lithuanian lietuvių | cikloheksamidas (ISO) 4-{}{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oksocikloheksil]-2-hidroksietil}}piperidino-2,6-dionas |
| Hungarian magyar | cycloheximid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oxociklohexil]-2-hidroxietil}piperidin-2,6-dion |
| Maltese Malti | ċikloeżimmid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-ossoċikloeżil]-2-idrossietil}piperidina-2,6-dion |
| Dutch Nederlands | cycloheximide (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dion |
| Polish polski | cykloheksymid (ISO) 3-{(2R)-2-[(1 S ,3 S ,5 S )-3,5-dimetylo-2-oksocykloheksylo]-2-hydroksyetylo}glutarimid |
| Portuguese português | ciclo-heximide (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oxociclo-hexil]-2-hidroxietil}piperidina-2,6-diona |
| Romanian română | cicloheximidă (ISO) 4-{(2 R -2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oxociclohexil]-2-hidroxietil}piperidin-2,6-dionă |
| Slovak slovenčina | cykloheximid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetyl-2-oxocyklohexyl]-2-hydroxyetyl}}piperidín-2,6-dión |
| Slovenian slovenščina | cikloheksimid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetil-2-oksocikloheksil]-2-hidroksietil}piperidin-2,6-dion |
| Finnish suomi | sykloheksimidi (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetyyli-2-oksosykloheksyyli]-2- hydroksietyyli}piperidiini-2,6-dioni |
| Swedish svenska | cykloheximid (ISO) 4-{(2 R )-2-[(1 S ,3 S ,5 S )-3,5-dimetyl-2-oxocyklohexyl]-2-hydroxietyl}piperidin-2,6-dion |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Cycloheximide GHS label elements
Everything CLP Annex VI fixes for Cycloheximide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Cycloheximide
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May damage the unborn child.
- Fatal if swallowed.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Cycloheximide in the GHS label constructor →
07 · Physical and chemical properties
Cycloheximide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Cycloheximide melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 25 °C (77 °F) | Cycloheximide acetate | HSDB |
| 120.25 °C (248.5 °F) | range, midpoint shown | HSDB | |
| 120.28 °C (248.5 °F) | range, midpoint shown | CAMEO |
Cycloheximide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | INSOL IN PETROLEUM ETHER | HSDB | |
| Isopropyl alcohol 5.5 g/100 ml; acetone 33.0 g/100 ml; cyclohexanone 19.0 g/100 ml (@ 20 °C) | at 20 °C | HSDB | |
| In water, 2.1X10-4 mg/l @ 25 °C | at 25 °C | HSDB |
Cycloheximide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.006 mmHg | at 25 °C | DOE PAC |
Cycloheximide corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | NONCORROSIVE | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
08 · Handling and storage
Cycloheximide storage and handling
Cycloheximide safe storage
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Cycloheximide reactivity
CYCLOHEXIMIDE is an imide. This chemical is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides. It decomposes rapidly in alkali at room temperature. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Cycloheximide in the storage compatibility matrix →
09 · Questions
Cycloheximide — frequently asked questions
What is the CAS number of Cycloheximide?
The CAS number of Cycloheximide is 66-81-9. Its EC number is 200-636-0.
What does a Cycloheximide label have to show?
Under CLP Annex VI the label for Cycloheximide carries the pictograms Skull and crossbones, Health hazard and Environment and the signal word is Danger.
Is Cycloheximide flammable?
CLP Annex VI assigns Cycloheximide no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Cycloheximide a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Cycloheximide. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the melting point of Cycloheximide?
The melting point reported for Cycloheximide is 25 °C (77 °F), Cycloheximide acetate (HSDB).
Nearby
Substances next to Cycloheximide
Keep going: substances starting with C, or search the whole database by name, CAS number, pictogram or signal word.