Substance profile
Dimethyl-p-toluidine
Dimethyl-p-toluidine is a clear colorless liquid with an aromatic odor.
01 · Identification
What Dimethyl-p-toluidine is
Dimethyl-p-toluidine is a clear colorless liquid with an aromatic odor. Its molecular formula is C9H13N and its molecular weight is 135.21 g/mol. It boils at 211 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Dimethyl-p-toluidine identifiers and molecular data
Dimethyl-p-toluidine CAS number and EC number
Dimethyl-p-toluidine molecular formula and molecular weight
Other names for Dimethyl-p-toluidine
- N,N-dimethyl-p-toluidine
03 · GHS classification
Dimethyl-p-toluidine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Dimethyl-p-toluidine pictograms and signal word
Dimethyl-p-toluidine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 3 | H412 | — |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Dimethyl-p-toluidine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H301 | Toxic if swallowed. |
| H332 | Harmful if inhaled. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H412 | Harmful to aquatic life with long lasting effects. |
This page lists only the codes assigned to Dimethyl-p-toluidine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Dimethyl-p-toluidine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Dimethyl-p-toluidine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Dimethyl-p-toluidine precautionary statements
CLP Annex VI assigns 15 precautionary statements to Dimethyl-p-toluidine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Dimethyl-p-toluidine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | N , N -диметил- p -толуидин |
| Spanish español | N , N -Dimetil- p -toluidina |
| Czech čeština | N,N -dimethyl- p -toluidin |
| Danish dansk | N,N -dimethyl- p -toluidin |
| German Deutsch | N,N -Dimethyl- p -toluidin |
| Estonian eesti | N , N -dimetüül- p -toluidiin |
| Greek ελληνικά | N,N -διμεθυλο- p -τολουιδίνη |
| English English | N,N -dimethyl- p -toluidine |
| French français | N,N -diméthyl-p-toluidine |
| Croatian hrvatski | N,N -dimetil- p -toluidin |
| Italian italiano | N,N -dimetil- p -toluidina |
| Latvian latviešu | N,N -dimetil- p -toluidīns |
| Lithuanian lietuvių | N,N -dimetil- p -toluidinas |
| Hungarian magyar | N,N -dimetil- p -toluidin |
| Maltese Malti | N,N -dimetil- p -toluwidina |
| Dutch Nederlands | N,N -dimethyl- p -toluïdine |
| Polish polski | N,N -dimetylo- p -toluidyna |
| Portuguese português | N , N -dimetil- p -toluidina |
| Romanian română | N,N -dimetil- p -toluidină |
| Slovak slovenčina | N,N -dimetyl- para -toluidín |
| Slovenian slovenščina | N,N -dimetil- p -toluidin |
| Finnish suomi | N,N -dimetyyli- p -toluidiini |
| Swedish svenska | N,N -dimetyl- p -toluidin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Dimethyl-p-toluidine GHS label elements
Everything CLP Annex VI fixes for Dimethyl-p-toluidine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Dimethyl-p-toluidine
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Toxic if swallowed.
- Harmful if inhaled.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Dimethyl-p-toluidine in the GHS label constructor →
07 · Health hazards
Dimethyl-p-toluidine health hazards and exposure limits
Dimethyl-p-toluidine hazard summary
Can induce methemoglobinemia; [ICSC] See Carcinogenicity of some industrial chemicals, Volume 115. [IARC, News Release, 23 February 2016]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Dimethyl-p-toluidine carcinogenicity classification
Under the conditions of these 2-year oral gavage studies, there was clear evidence of carcinogenic activity of N,N-dimethyl-p-toluidine in male F344/N rats based on increased incidences of hepatocellular carcinoma, and hepatocellular adenoma or carcinoma (combined), and increased incidences of nasal cavity neoplasms (primarily nasal cavity transitional epithelium adenoma). The increased incidences of thyroid gland follicular cell neoplasms may have been related to treatment. There was clear evidence of carcinogenic activity of N,N-dimethyl-p-toluidine in female F344/N rats based on increased incidences of hepatocellular carcinoma and hepatocellular adenoma or carcinoma (combined). The occurrence of nasal cavity transitional epithelium adenoma was considered to be related to treatment. There was clear evidence of carcinogenic activity of N,N-dimethyl-p-toluidine in male B6C3F1/N mice based on increased incidences of hepatocellular adenoma (multiple), hepatocellular carcinoma, and hepatoblastoma. There was clear evidence of carcinogenic activity of N,N-dimethyl-p-toluidine in female B6C3F1/N mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma and increased incidences of alveolar/ bronchiolar neoplasms (primarily adenoma). The increased incidences of forestomach squamous cell papilloma in female mice were considered to be related to treatment.
Source: US National Toxicology Program · TR-579: Toxicology and Carcinogenesis Studies of N,N-Dimethyl-p-Toluidine (CASRN 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies) (2012 )
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Dimethyl-p-toluidine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Dimethyl-p-toluidine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 211 °C (411.8 °F) | HSDB | |
| 215 °C (419 °F) | ICSC |
Dimethyl-p-toluidine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.9 g/cm³ | ICSC | |
| 0.9366 g/cm³ | at 20 °C | HSDB |
Dimethyl-p-toluidine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In water, 455 mg/L | HSDB | |
| Miscible with ethanol, ethyl ether; soluble in carbon tetrachloride | HSDB | ||
| In water, 650 mg/L at 37 °C | at 37 °C | HSDB |
Dimethyl-p-toluidine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.178 mmHg | at 25 °C | HSDB |
| 0.17 mmHg | Haz-Map |
Dimethyl-p-toluidine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 76 °C (168.8 °F) | closed cup | HSDB |
| 83 °C (181.4 °F) | ICSC |
Dimethyl-p-toluidine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.2 % by volume | HSDB |
Dimethyl-p-toluidine upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 7 % by volume | HSDB |
Dimethyl-p-toluidine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.7 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
Dimethyl-p-toluidine storage and handling
Dimethyl-p-toluidine safe storage
Separated from oxidants and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Dimethyl-p-toluidine storage conditions
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed.
Source: Hazardous Substances Data Bank (HSDB)
Dimethyl-p-toluidine incompatible materials
Incompatible materials acids, Acid chlorides, Acid anhydrides, Strong oxidizing agents
Source: Hazardous Substances Data Bank (HSDB)
Dimethyl-p-toluidine reactivity
N,N-DIMETHYL-P-TOLUIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Dimethyl-p-toluidine in the storage compatibility matrix →
10 · Questions
Dimethyl-p-toluidine — frequently asked questions
What is the CAS number of Dimethyl-p-toluidine?
The CAS number of Dimethyl-p-toluidine is 99-97-8. Its EC number is 202-805-4.
What is the chemical formula of Dimethyl-p-toluidine?
The molecular formula of Dimethyl-p-toluidine is C9H13N and its molecular weight is 135.21 g/mol.
What does a Dimethyl-p-toluidine label have to show?
Under CLP Annex VI the label for Dimethyl-p-toluidine carries the pictograms Skull and crossbones and Health hazard and the signal word is Danger.
Is Dimethyl-p-toluidine flammable?
CLP Annex VI assigns Dimethyl-p-toluidine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 76 °C (168.8 °F), closed cup (HSDB).
Is Dimethyl-p-toluidine a carcinogen?
Yes. CLP Annex VI classifies Dimethyl-p-toluidine as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of Dimethyl-p-toluidine?
The boiling point reported for Dimethyl-p-toluidine is 211 °C (411.8 °F) (HSDB).
How should Dimethyl-p-toluidine be stored?
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. (Hazardous Substances Data Bank (HSDB))
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