Substance profile
Guaiacol
Guaiacol is faintly yellowish, limpid, oily liquid or yellow crystals with an aromatic odor.
01 · Identification
What Guaiacol is
Guaiacol is faintly yellowish, limpid, oily liquid or yellow crystals with an aromatic odor. Its molecular formula is C7H8O2 and its molecular weight is 124.14 g/mol. It boils at 205 °C, melts at 32 °C, is soluble in water.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Guaiacol identifiers and molecular data
Guaiacol CAS number and EC number
Guaiacol molecular formula and molecular weight
03 · GHS classification
Guaiacol hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Guaiacol pictograms and signal word
Guaiacol hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
Guaiacol hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
This page lists only the codes assigned to Guaiacol. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Guaiacol
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Guaiacol issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Guaiacol precautionary statements
CLP Annex VI assigns 13 precautionary statements to Guaiacol. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Guaiacol name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | гвайакол |
| Spanish español | Guayacol |
| Czech čeština | guajakol 2-methoxyfenol |
| Danish dansk | guaiacol |
| German Deutsch | Guajakol 2-Methoxyphenol |
| Estonian eesti | guajakool |
| Greek ελληνικά | γουαϊακόλη |
| English English | guaiacol |
| French français | gaïacol |
| Croatian hrvatski | gvajakol |
| Italian italiano | guaiacolo 2-metossifenolo |
| Latvian latviešu | gvajakols |
| Lithuanian lietuvių | gvajakolis |
| Hungarian magyar | gvajakol |
| Maltese Malti | gwajakol |
| Dutch Nederlands | guajacol |
| Polish polski | gwajakol 2-metoksyfenol2-hydroksyanizol |
| Portuguese português | guaiacol |
| Romanian română | guaiacol |
| Slovak slovenčina | guajakol |
| Slovenian slovenščina | gvajakol |
| Finnish suomi | guajakoli |
| Swedish svenska | guajakol |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Guaiacol GHS label elements
Everything CLP Annex VI fixes for Guaiacol, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Guaiacol
- Harmful if swallowed.
- Causes skin irritation.
- Causes serious eye irritation.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF IN EYES:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Guaiacol in the GHS label constructor →
07 · Health hazards
Guaiacol health hazards and exposure limits
Guaiacol hazard summary
Emergency treatment: Phenol and related agents; [HSDB] May cause skin and eye irritation; Can be absorbed through skin; [CAMEO] Causes somnolence and acts as a general anesthetic; Causes elevation of transaminase enzymes; Mild eye irritant in rabbits; [RTECS] Safe when used as a flavoring agent in food; [JECFA] An irritant; [MSDSonline] See Phenol.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Guaiacol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Guaiacol boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 205 °C (401 °F) | HSDB | |
| 205 °C (401 °F) | range, midpoint shown, at 760 mmHg | CAMEO | |
| 204.5 °C (400.1 °F) | range, midpoint shown | JECFA |
Guaiacol melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 32 °C (89.6 °F) | HSDB | |
| 28 °C (82.4 °F) | CAMEO |
Guaiacol density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.13 g/cm³ | at 21.39 °C | CAMEO |
| 1.1287 g/cm³ | at 21 °C | HSDB | |
| 1.1345 g/cm³ | range, midpoint shown | JECFA |
Guaiacol solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in carbon tetrachloride | HSDB | |
| Miscible with alcohol, chloroform, ether, oils, glacial acetic acid; slightly soluble in petroleum ether; soluble in sodium hydroxide solution | HSDB | ||
| 1 g is soluble in 60-70 mL water, in 1 mL glycerol | o-methoxyphenol | HSDB |
Guaiacol vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.103 mmHg | HSDB | |
| 5 mmHg | at 78.89 °C | CAMEO | |
| 0.1 mmHg | Haz-Map |
Guaiacol flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 82.22 °C (180 °F) | HSDB |
Guaiacol vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.27 (air = 1) | CAMEO |
Guaiacol odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Odor threshold = 0.001-0.002 ppm (recognition) | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Guaiacol fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Guaiacol fire potential
This material is combustible when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Guaiacol storage and handling
Guaiacol storage conditions
Store in tight, light-resistant container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.
Source: Hazardous Substances Data Bank (HSDB)
Guaiacol reactivity
O-METHOXYPHENOL may react with oxidizing materials. It forms salts readily with bases. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Guaiacol in the storage compatibility matrix →
11 · Questions
Guaiacol — frequently asked questions
What is the CAS number of Guaiacol?
The CAS number of Guaiacol is 90-05-1. Its EC number is 201-964-7.
What is the chemical formula of Guaiacol?
The molecular formula of Guaiacol is C7H8O2 and its molecular weight is 124.14 g/mol.
What does a Guaiacol label have to show?
Under CLP Annex VI the label for Guaiacol carries the pictogram Exclamation mark and the signal word is Warning.
Is Guaiacol flammable?
CLP Annex VI assigns Guaiacol no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 82.22 °C (180 °F) (HSDB).
Is Guaiacol a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Guaiacol. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Guaiacol?
The boiling point reported for Guaiacol is 205 °C (401 °F) (HSDB).
What is the melting point of Guaiacol?
The melting point reported for Guaiacol is 32 °C (89.6 °F) (HSDB).
How should Guaiacol be stored?
Store in tight, light-resistant container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Guaiacol
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