Substance profile
Imidazole
Imidazole is monoclinic prisms from benzene with an amine-like odor.
01 · Identification
What Imidazole is
Imidazole is monoclinic prisms from benzene with an amine-like odor. Its molecular formula is C3H4N2 and its molecular weight is 68.08 g/mol. It boils at 257 °C, melts at 89.5 °C, is very soluble in water.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Imidazole identifiers and molecular data
Imidazole CAS number and EC number
Imidazole molecular formula and molecular weight
03 · GHS classification
Imidazole hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Imidazole pictograms and signal word
Imidazole hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 1A or 1B or 1C | H314 | GHS05 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Imidazole hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H360D | May damage the unborn child. |
| H302 | Harmful if swallowed. |
| H314 | Causes severe skin burns and eye damage. |
This page lists only the codes assigned to Imidazole. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Imidazole
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Imidazole issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Imidazole precautionary statements
CLP Annex VI assigns 8 precautionary statements to Imidazole. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Imidazole name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | имидазол |
| Spanish español | imidazol |
| Czech čeština | imidazol |
| Danish dansk | imidazol |
| German Deutsch | Imidazol |
| Estonian eesti | imidasool |
| Greek ελληνικά | ιμιδαζόλιο |
| English English | imidazole |
| French français | imidazole |
| Croatian hrvatski | imidazol |
| Italian italiano | imidazolo |
| Latvian latviešu | imidazols |
| Lithuanian lietuvių | imidazolas |
| Hungarian magyar | imidazol |
| Maltese Malti | imidażol |
| Dutch Nederlands | imidazool |
| Polish polski | imidazol |
| Portuguese português | imidazole |
| Romanian română | imidazol |
| Slovak slovenčina | imidazol |
| Slovenian slovenščina | imidazol |
| Finnish suomi | Imidatsoli |
| Swedish svenska | imidazol |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Imidazole GHS label elements
Everything CLP Annex VI fixes for Imidazole, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Imidazole
- May damage the unborn child.
- Harmful if swallowed.
- Causes severe skin burns and eye damage.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Rinse mouth.
- Do NOT induce vomiting.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Imidazole in the GHS label constructor →
07 · Health hazards
Imidazole health hazards and exposure limits
Imidazole hazard summary
Corrosive to skin and irritating to eyes in rabbits--may cause permanent eye injury; A 90-day oral study of rats showed histopathological changes of the liver and kidney at 180 mg/kg/day; No evidence of neurotoxicity; No effects on sperm parameters or toxicity to male or female reproductive organs observed in the 90-day study; Teratogenicity and developmental toxicity observed at doses maternally toxic in rats; [OECD SIDS] No increase in abnormalities of offspring in rats dosed 240 mg/kg by gavage during embryogenesis (non-standard study, no information on maternal toxicity); [REPROTOX] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; May be toxic to human reproduction and cause harm to the unborn child; [Sigma-Aldrich MSDS]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Imidazole properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Imidazole boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 257 °C (494.6 °F) | HSDB | |
| 268 °C (514.4 °F) | ICSC | ||
| 257 °C (494.6 °F) | at 760 mmHg | DOE PAC |
Imidazole melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 89.52 °C (193.1 °F) | HSDB | |
| 89 °C (192.2 °F) | ICSC | ||
| 90.5 °C (194.9 °F) | HMDB |
Imidazole density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.03 g/cm³ | ICSC | |
| 1.0303 g/cm³ | at 101 °C | HSDB |
Imidazole solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Very soluble in water | HSDB | |
| In water, 241 g/100 g at 20 °C | at 20 °C | HSDB | |
| In water, 2060 g/kg H2O at 19 °C | at 19 °C | HSDB |
Imidazole vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0023 mmHg | at 20 °C | ICSC |
| 0.0025 mmHg | at 25 °C | HSDB | |
| 0.002 mmHg | Haz-Map |
Imidazole flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 145 °C (293 °F) | HSDB |
Imidazole autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 480 °C (896 °F) | HSDB |
Imidazole lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Dust explosion possible if in powder or granular form, mixed with air. | HSDB |
Imidazole vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 2.35 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Imidazole fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Imidazole fire potential
Combustible.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Imidazole storage and handling
Imidazole safe storage
Separated from strong acids and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Imidazole storage conditions
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.
Source: Hazardous Substances Data Bank (HSDB)
Imidazole incompatible materials
Incompatible materials: acids, acid anhydrides, strong oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Imidazole in the storage compatibility matrix →
11 · Questions
Imidazole — frequently asked questions
What is the CAS number of Imidazole?
The CAS number of Imidazole is 288-32-4. Its EC number is 206-019-2.
What is the chemical formula of Imidazole?
The molecular formula of Imidazole is C3H4N2 and its molecular weight is 68.08 g/mol.
What does a Imidazole label have to show?
Under CLP Annex VI the label for Imidazole carries the pictograms Health hazard, Exclamation mark and Corrosion and the signal word is Danger.
Is Imidazole flammable?
CLP Annex VI assigns Imidazole no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 145 °C (293 °F) (HSDB).
Is Imidazole a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Imidazole. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Imidazole?
The boiling point reported for Imidazole is 257 °C (494.6 °F) (HSDB).
What is the melting point of Imidazole?
The melting point reported for Imidazole is 89.52 °C (193.1 °F) (HSDB).
How should Imidazole be stored?
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Imidazole
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