Substance profile
Propyl 3,4,5-trihydroxybenzoate
Propyl 3,4,5-trihydroxybenzoate is a white to creamy-white crystalline powder and is odorless.
01 · Identification
What Propyl 3,4,5-trihydroxybenzoat… is
Propyl 3,4,5-trihydroxybenzoate is a white to creamy-white crystalline powder and is odorless. Its molecular formula is C10H12O5 and its molecular weight is 212.2 g/mol. It melts at 150 °C.
Under the GHS it carries the signal word Warning.
02 · Identifiers
Propyl 3,4,5-trihydroxybenzoat… identifiers and molecular data
Propyl 3,4,5-trihydroxybenzoat… CAS number and EC number
Propyl 3,4,5-trihydroxybenzoat… molecular formula and molecular weight
03 · GHS classification
Propyl 3,4,5-trihydroxybenzoat… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Propyl 3,4,5-trihydroxybenzoat… pictograms and signal word
Propyl 3,4,5-trihydroxybenzoat… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Propyl 3,4,5-trihydroxybenzoat… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H302 | Harmful if swallowed. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Propyl 3,4,5-trihydroxyben…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Propyl 3,4,5-trihydroxyben…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Propyl 3,4,5-trihydrox… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Propyl 3,4,5-trihydroxybenzoat… precautionary statements
CLP Annex VI assigns 12 precautionary statements to Propyl 3,4,5-trihydroxyben…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Propyl 3,4,5-trihydroxybenzoat… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | пропилов 3,4,5-трихидроксибензоат |
| Spanish español | 3,4,5-Trihidroxibenzoato de propilo |
| Czech čeština | propyl-3,4,5-trihydroxybenzoát |
| Danish dansk | propyl-3,4,5-trihydroxybenzoat |
| German Deutsch | Propyl-3,4,5-trihydroxybenzoat |
| Estonian eesti | propüül-3,4,5-trihüdroksübensoaat |
| Greek ελληνικά | 3,4,5-τριυδροξυβενζοϊκό προπύλιο |
| English English | propyl 3,4,5-trihydroxybenzoate |
| French français | 3,4,5-trihydroxybenzoate de propyle |
| Croatian hrvatski | propil-3,4,5-trihidroksibenzoat |
| Italian italiano | 3,4,5-triidrossibenzoato di propile |
| Latvian latviešu | propil-3,4,5-trihidroksibenzoāts |
| Lithuanian lietuvių | propilo 3,4,5-trihidroksibenzenkarboksilatas |
| Hungarian magyar | propil-3,4,5-trihidroxibenzoát |
| Maltese Malti | 3,4,5-triidrossibenżoat tal-propil |
| Dutch Nederlands | propyl-3,4,5-trihydroxybenzoaat |
| Polish polski | 3,4,5-trihydroksybenzoesan propylu |
| Portuguese português | 3,4,5-tri-hidroxibenzoato de propilo |
| Romanian română | 3,4,5-trihidroxibenzoat de propil |
| Slovak slovenčina | propyl-3,4,5-trihydroxybenzoát |
| Slovenian slovenščina | propil 3,4,5-trihidroksibenzoat |
| Finnish suomi | propyyli-3,4,5-trihydroksibentsoaatti |
| Swedish svenska | propyl-3,4,5-trihydroxibensoat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Propyl 3,4,5-trihydroxybenzoat… GHS label elements
Everything CLP Annex VI fixes for Propyl 3,4,5-trihydroxyben…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
Propyl 3,4,5-trihydroxybenzoat…
- Harmful if swallowed.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation or rash occurs:
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Propyl 3,4,5-trihydroxyben… in the GHS label constructor →
07 · Health hazards
Propyl 3,4,5-trihydroxybenzoat… health hazards and exposure limits
Propyl 3,4,5-trihydroxybenzoat… hazard summary
Cause allergic contact dermatitis in bakers and other workers; [HSDB] A skin, eye, mucous membrane, and upper respiratory tract irritant; May cause skin sensitization; [CAMEO] Causes convulsions in lethal dose studies of rats; [RTECS] May cause skin sensitization; [eChemPortal: ESIS] Does not increase birth defects in animal experiments; [REPROTOX] ADI = 0-1.4 mg/kg when used as an antioxidant in food; [JECFA]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Propyl 3,4,5-trihydroxybenzoat… carcinogenicity classification
Under the conditions of this bioassay, propyl gallate was not considered carcinogenic for F344/N rats, although there was evidence of an increased proportion of low-dose male rats with preputial gland tumors, islet-cell tumors of the pancreas, and pheochromocytomas of the adrenal glands; rare tumors of the brain occurred in two low-dose females. Propyl gallate was not considered to be carcinogenic for B6C3F1 mice of either sex, although the increased incidence of malignant lymphoma in male mice may have been related to the dietary administration of propyl gallate.
Source: US National Toxicology Program · TR-240: Carcinogenesis Bioassay of Propyl Gallate (CASRN 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study) (1982 )
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Propyl 3,4,5-trihydroxybenzoat… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Propyl 3,4,5-trihydroxybenzoat… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | Decomposes (NTP, 1992) | decomposes | CAMEO |
Propyl 3,4,5-trihydroxybenzoat… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 150 °C (302 °F) | CAMEO | |
| 148 °C (298.4 °F) | range, midpoint shown | HSDB |
Propyl 3,4,5-trihydroxybenzoat… density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.21 g/cm³ | HSDB |
Propyl 3,4,5-trihydroxybenzoat… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in acetone and 2-butanol | HSDB | |
| In water, 3490 mg/L at 25 deg, 2790 mg/L at 20 °C, 3790 mg/L at 30 °C | at 20 °C | HSDB | |
| Solubility at 25 °C: in water 0.35 g/100 mL | at 25 °C | HSDB |
Propyl 3,4,5-trihydroxybenzoat… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 187 °C (368.6 °F) | HSDB | |
| 186.67 °C (368 °F) | CAMEO |
Propyl 3,4,5-trihydroxybenzoat… vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 7.3 (air = 1) | CAMEO |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Propyl 3,4,5-trihydroxyben… fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Propyl 3,4,5-trihydroxybenzoat… fire potential
Combustible when exposed to heat or flame ... .
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Propyl 3,4,5-trihydroxybenzoat… storage and handling
Propyl 3,4,5-trihydroxybenzoat… storage conditions
Keep container tightly closed in a dry and well-ventilated place.
Source: Hazardous Substances Data Bank (HSDB)
Propyl 3,4,5-trihydroxybenzoat… incompatible materials
Incompatible materials: Strong oxidizing agents, strong acids, strong bases, strong reducing agents
Source: Hazardous Substances Data Bank (HSDB)
Propyl 3,4,5-trihydroxybenzoat… reactivity
PROPYL GALLATE can react with oxidizing agents. Incompatible with strong acids, strong bases and strong reducing agents. Darkens in the presence of iron and iron salts. Contact with metals should be avoided (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Propyl 3,4,5-trihydroxybe… in the storage compatibility matrix →
11 · Questions
Propyl 3,4,5-trihydroxybenzoat… — frequently asked questions
What is the CAS number of Propyl 3,4,5-trihydroxybenzoat…?
The CAS number of Propyl 3,4,5-trihydroxybenzoat… is 121-79-9. Its EC number is 204-498-2.
What is the chemical formula of Propyl 3,4,5-trihydroxybenzoat…?
The molecular formula of Propyl 3,4,5-trihydroxybenzoat… is C10H12O5 and its molecular weight is 212.2 g/mol.
What does a Propyl 3,4,5-trihydroxybenzoat… label have to show?
Under CLP Annex VI the label for Propyl 3,4,5-trihydroxybenzoat… carries the pictograms Exclamation mark and Environment and the signal word is Warning.
Is Propyl 3,4,5-trihydroxybenzoat… flammable?
CLP Annex VI assigns Propyl 3,4,5-trihydroxybenzoat… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 187 °C (368.6 °F) (HSDB).
Is Propyl 3,4,5-trihydroxybenzoat… a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Propyl 3,4,5-trihydroxybenzoat…. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Propyl 3,4,5-trihydroxybenzoat…?
The boiling point reported for Propyl 3,4,5-trihydroxybenzoat… is Decomposes (NTP, 1992), decomposes (CAMEO).
What is the melting point of Propyl 3,4,5-trihydroxybenzoat…?
The melting point reported for Propyl 3,4,5-trihydroxybenzoat… is 150 °C (302 °F) (CAMEO).
How should Propyl 3,4,5-trihydroxybenzoat… be stored?
Keep container tightly closed in a dry and well-ventilated place. (Hazardous Substances Data Bank (HSDB))
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