Substance profile
Prothoate
Prothoate is colorless yellow crystals (tech is an amber to yellow semi-solid) with a camphor-like odor.
01 · Identification
What Prothoate is
Prothoate is colorless yellow crystals (tech is an amber to yellow semi-solid) with a camphor-like odor. Its molecular formula is C9H20NO3PS2 and its molecular weight is 285.4 g/mol. It boils at 330 °C, melts at 28.5 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Prothoate identifiers and molecular data
Prothoate CAS number and EC number
Prothoate molecular formula and molecular weight
Other names for Prothoate
- prothoate (ISO)
- O,O-diethyl isopropylcarbamoylmethyl phosphorodithioate
03 · GHS classification
Prothoate hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Prothoate pictograms and signal word
Prothoate hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 1 or 2 | H300 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 1 or 2 | H310 | GHS06 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 3 | H412 | — |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Prothoate hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H310 | Fatal in contact with skin. |
| H300 | Fatal if swallowed. |
| H412 | Harmful to aquatic life with long lasting effects. |
This page lists only the codes assigned to Prothoate. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Prothoate
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Prothoate issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Prothoate precautionary statements
CLP Annex VI assigns 9 precautionary statements to Prothoate. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Prothoate name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | протоат (ISO) O , O -диетилов изопропилкарбамоилметилов фосфородитиоат |
| Spanish español | Protoato (ISO) fosforoditioato de O, O -dietilo e isopropilcarbamoilmetilo |
| Czech čeština | prothoát (ISO) O, O -diethyl-(isopropylkarbamoyl)methyl-fosforodithioát |
| Danish dansk | prothoat (ISO) O, O- diethylisopropylcarbamoylmethyldithiophosphat |
| German Deutsch | Prothoat (ISO) O , O -Diethylisopropylcarbamoylmethyl phosphorodithioat |
| Estonian eesti | protoaat (ISO) O , O -dietüülisopropüülkarbamoüülmetüülfosforoditioaat |
| Greek ελληνικά | prothoate (προθοάτη) (ISO) διθειοφωσφορικό O , O -διαιθύλιο ισοπροπυλοκαρβαμοϋλομεθύλιο |
| English English | prothoate (ISO) O , O -diethyl isopropylcarbamoylmethyl phosphorodithioate |
| French français | prothoate (ISO) phosphorodithioate de O , O -diéthyle et d'isopropylcarbamoylméthyle |
| Croatian hrvatski | protoat (ISO) O , O -dietil-izopropil-karbamoil-metil-fosforoditioat |
| Italian italiano | protoato (ISO) ditiofosfato di O, O-dietile e isopropilcarbammoilmetile |
| Latvian latviešu | protoāts (ISO) O , O -dietilizopropilkarbamoilmetilfosforditioāts |
| Lithuanian lietuvių | protoatas (ISO) O , O -dietilizopropilkarbamoilmetilditiofosfatas |
| Hungarian magyar | protoát (ISO) O , O -dietil-izopropil-karbamoilmetil-ditiofoszfát |
| Maltese Malti | protoat (ISO) fosforoditijoat tal-isopropilkarbamojlmetil ta’ O , O -dietil |
| Dutch Nederlands | prothoaat (ISO) O , O -diëthylisopropylcarbamoylmethyldithiofosfaat |
| Polish polski | protoat (ISO) ditiofosforan O , O -dietylu- S -(izopropylokarbamoilo)metylu |
| Portuguese português | protoato (ISO) ditiofosfato de O , O -dietilo e de isopropilcarbamoilmetilo |
| Romanian română | protoat (ISO) ditiofosfat de O , O -dietil și de izopropilcarbamoil metil |
| Slovak slovenčina | protoát (ISO) O, O -dietyl- S -[(izopropylkarbamoyl)metyl]- fosforoditioát |
| Slovenian slovenščina | protoat (ISO) O , O -dietil izopropilkarbamoilmetil fosforoditioat |
| Finnish suomi | protoaatti (ISO) O , O -dietyyli-isopropyylikarbamoyylimetyylifosforoditioaatti |
| Swedish svenska | protoat (ISO) O , O -dietylisopropylkarbamoylmetylfosforditioat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Prothoate GHS label elements
Everything CLP Annex VI fixes for Prothoate, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Prothoate
- Fatal in contact with skin.
- Fatal if swallowed.
- Harmful to aquatic life with long lasting effects.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- Immediately call a POISON CENTER/doctor/…
- Rinse mouth.
- Wash with plenty of water/…
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Prothoate in the GHS label constructor →
07 · Health hazards
Prothoate health hazards and exposure limits
Prothoate hazard summary
May cause death or permanent injury from exposure during normal use; A cholinesterase inhibitor that may cause nervous system damage and liver injury; [HSDB] Extremely toxic cholinesterase inhibitor; [CAMEO] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Prothoate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Prothoate boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 330 °C (626 °F) | at 760 mmHg | DOE PAC |
Prothoate melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 28.5 °C (83.3 °F) | HSDB |
Prothoate density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.151 g/cm³ | at 32 °C | HSDB |
Prothoate solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Miscible with most organic solvents e.g. hexane, cyclohexane, higher petroleum fractions <30. Light petroleum <20, glycerol <10 (all in g/kg , 20 °C) | at 20 °C | HSDB |
| In water, 2.5X10+3 mg/L at 20 °C | at 20 °C | HSDB |
Prothoate vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0001 mmHg | at 25 °C | DOE PAC |
| 0.0000975 mmHg | at 40 °C | HSDB | |
| 0.0001 mmHg | at 40 °C | CAMEO |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Prothoate fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Prothoate fire potential
This material may burn, but does not ignite readily.
Source: Hazardous Substances Data Bank (HSDB)
Solubility
SOLIDIFIES AT 21 TO 24 °C; AMBER TO YELLOW SEMI-SOLID; MISCIBLE AT 20 °C WITH MOST ORGANIC SOLVENTS; SOLUBILITY LESS THAN: 10 G/KG GLYCEROL, 20 G/KG LIGHT PETROLEUM, 30 G/KG CYCLOHEXANE, HEXANE & HIGHER PETROLEUM FRACTIONS /TECHNICAL PRODUCT/
Source: HSDB
10 · Handling and storage
Prothoate storage and handling
Prothoate storage conditions
Storage: Prior to working with this chemical you should be trained on its proper handling and storage. Store in tightly closed containers in a cool, well-ventilated area. Where possible, automatically transfer material from drums or other storage containers to process containers. Sources of ignition such as smoking and open flames are prohibited where this chemical is handled, used, or stored. Metal containers involving the transfer of this chemical should be grounded and bonded. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.
Source: Hazardous Substances Data Bank (HSDB)
Prothoate reactivity
Organothiophosphates, such as PROTHOATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Prothoate in the storage compatibility matrix →
11 · Questions
Prothoate — frequently asked questions
What is the CAS number of Prothoate?
The CAS number of Prothoate is 2275-18-5. Its EC number is 218-893-2.
What is the chemical formula of Prothoate?
The molecular formula of Prothoate is C9H20NO3PS2 and its molecular weight is 285.4 g/mol.
What does a Prothoate label have to show?
Under CLP Annex VI the label for Prothoate carries the pictogram Skull and crossbones and the signal word is Danger.
Is Prothoate flammable?
CLP Annex VI assigns Prothoate no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Prothoate a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Prothoate. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Prothoate?
The boiling point reported for Prothoate is 330 °C (626 °F), at 760 mmHg (DOE PAC).
What is the melting point of Prothoate?
The melting point reported for Prothoate is 28.5 °C (83.3 °F) (HSDB).
How should Prothoate be stored?
Storage: Prior to working with this chemical you should be trained on its proper handling and storage. Store in tightly closed containers in a cool, well-ventilated area. Where possible, automatically transfer material from drums or other storage containers to process containers. Sources of ignition such as smoking and open flames are prohibited where this chemical is handled, used, or stored. Metal containers involving the transfer of this chemical should be grounded and bonded. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Prothoate
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