Substance profile
Thioacetamide
Thioacetamide is crystals from benzene with slight odor of mercaptans.
01 · Identification
What Thioacetamide is
Thioacetamide is crystals from benzene with slight odor of mercaptans. Its molecular formula is C2H5NS and its molecular weight is 75.14 g/mol. It melts at 116 °C, is miscible with water.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
Thioacetamide identifiers and molecular data
Thioacetamide CAS number and EC number
Thioacetamide molecular formula and molecular weight
03 · GHS classification
Thioacetamide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Thioacetamide pictograms and signal word
Thioacetamide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 3 | H412 | — |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Thioacetamide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H412 | Harmful to aquatic life with long lasting effects. |
This page lists only the codes assigned to Thioacetamide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Thioacetamide
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Thioacetamide issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Thioacetamide precautionary statements
CLP Annex VI assigns 17 precautionary statements to Thioacetamide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Thioacetamide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | тиоацетамид |
| Spanish español | Tioacetamida |
| Czech čeština | thioacetamid |
| Danish dansk | thioacetamid |
| German Deutsch | Thioacetamid |
| Estonian eesti | tioatseetamiid |
| Greek ελληνικά | θειακεταμίδιο |
| English English | thioacetamide |
| French français | thioacétamide |
| Croatian hrvatski | tioacetamid |
| Italian italiano | tioacetammide |
| Latvian latviešu | tioacetamīds |
| Lithuanian lietuvių | tioacetamidas |
| Hungarian magyar | tioacetamid |
| Maltese Malti | tijoaċetammid |
| Dutch Nederlands | thioaceetamide |
| Polish polski | tioacetamid |
| Portuguese português | tioacetamida |
| Romanian română | tioacetamidă |
| Slovak slovenčina | tioacetamid |
| Slovenian slovenščina | tioacetamid |
| Finnish suomi | tioasetamidi |
| Swedish svenska | tioacetamid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Thioacetamide GHS label elements
Everything CLP Annex VI fixes for Thioacetamide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Thioacetamide
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Causes skin irritation.
- Causes serious eye irritation.
- Harmful to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF IN EYES:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Thioacetamide in the GHS label constructor →
07 · Health hazards
Thioacetamide health hazards and exposure limits
Thioacetamide hazard summary
Reports of degenerative liver changes following ingestion of the juice of oranges dipped for 2-5 seconds in 5% solution; Cirrhosis and other adverse changes (including tumors) of the liver observed in rats, mice, and dogs in feeding studies; [HSDB] May cause liver injury; A possible human carcinogen; [ICSC] A skin and eye irritant; [eChemPortal: ESIS] A skin and strong eye irritant; [Alfa Aesar MSDS]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Thioacetamide carcinogenicity classification
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
Thioacetamide: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Thioacetamide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Thioacetamide melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 115.5 °C (239.9 °F) | DOE PAC | |
| 113.5 °C (236.3 °F) | range, midpoint shown | HSDB | |
| 113.06 °C (235.5 °F) | range, midpoint shown | CAMEO |
Thioacetamide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In ethanol 26.4 g/100 g; sparingly sol in ether | HSDB | |
| Miscible in benzene | HSDB | ||
| MISCIBLE IN PETROLEUM ETHER | HSDB |
Thioacetamide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 15.2 mmHg | Haz-Map |
Thioacetamide odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Medium odor threshold level: 94.7 ppm in 50% aqueous ethylene glycol. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
Thioacetamide storage and handling
Thioacetamide safe storage
Separated from food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Thioacetamide storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
Thioacetamide incompatible materials
FORMS COMPD & SULFIDES WITH SALTS OF HEAVY METALS; HYDROLYZED BY ACIDS OR BASES, FORMING ACETIC ACID, AMMONIA, NITROGEN & HYDROGEN SULFIDE
Source: Hazardous Substances Data Bank (HSDB)
Thioacetamide reactivity
THIOACETAMIDE reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Thioacetamide in the storage compatibility matrix →
10 · Questions
Thioacetamide — frequently asked questions
What is the CAS number of Thioacetamide?
The CAS number of Thioacetamide is 62-55-5. Its EC number is 200-541-4.
What is the chemical formula of Thioacetamide?
The molecular formula of Thioacetamide is C2H5NS and its molecular weight is 75.14 g/mol.
What does a Thioacetamide label have to show?
Under CLP Annex VI the label for Thioacetamide carries the pictograms Health hazard and Exclamation mark and the signal word is Danger.
Is Thioacetamide flammable?
CLP Annex VI assigns Thioacetamide no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Thioacetamide a carcinogen?
Yes. CLP Annex VI classifies Thioacetamide as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the melting point of Thioacetamide?
The melting point reported for Thioacetamide is 115.5 °C (239.9 °F) (DOE PAC).
How should Thioacetamide be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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