Substance profile
1,2,4-Trichlorobenzene
1,2,4-Trichlorobenzene is a colorless liquid with an aromatic odor.
01 · Identification
What 1,2,4-Trichlorobenzene is
1,2,4-Trichlorobenzene is a colorless liquid with an aromatic odor. Its molecular formula is C6H3Cl3 and its molecular weight is 181.4 g/mol. It boils at 214 °C, melts at 16.9 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
1,2,4-Trichlorobenzene identifiers and molecular data
1,2,4-Trichlorobenzene CAS number and EC number
1,2,4-Trichlorobenzene molecular formula and molecular weight
03 · GHS classification
1,2,4-Trichlorobenzene hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
1,2,4-Trichlorobenzene pictograms and signal word
1,2,4-Trichlorobenzene hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
1,2,4-Trichlorobenzene hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 1,2,4-Trichlorobenzene. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 1,2,4-Trichlorobenzene
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,2,4-Trichlorobenzene issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
1,2,4-Trichlorobenzene precautionary statements
CLP Annex VI assigns 13 precautionary statements to 1,2,4-Trichlorobenzene. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
1,2,4-Trichlorobenzene name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 1,2,4-трихлоробензен |
| Spanish español | 1,2,4-Triclorobenceno |
| Czech čeština | 1,2,4-trichlorbenzen |
| Danish dansk | 1,2,4-trichlorbenzen |
| German Deutsch | 1,2,4-Trichlorbenzol |
| Estonian eesti | 1,2,4-triklorobenseen |
| Greek ελληνικά | 1,2,4-τριχλωροβενζόλιο |
| English English | 1,2,4-trichlorobenzene |
| French français | 1,2,4-trichlorobenzène |
| Croatian hrvatski | 1,2,4-triklorbenzen |
| Italian italiano | 1,2,4-triclorobenzene |
| Latvian latviešu | 1,2,4-trihlorbenzols |
| Lithuanian lietuvių | 1,2,4-trichlorbenzenas |
| Hungarian magyar | 1,2,4-triklórbenzol |
| Maltese Malti | 1,2,4-triklorobenżen |
| Dutch Nederlands | 1,2,4-trichloorbenzeen |
| Polish polski | 1,2,4-trichlorobenzen |
| Portuguese português | 1,2,4-triclorobenzeno |
| Romanian română | 1,2,4-triclorbenzen |
| Slovak slovenčina | 1,2,4-trichlórbenzén |
| Slovenian slovenščina | 1,2,4-triklorobenzen |
| Finnish suomi | 1,2,4-triklorobentseeni |
| Swedish svenska | 1,2,4-triklorbensen |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
1,2,4-Trichlorobenzene GHS label elements
Everything CLP Annex VI fixes for 1,2,4-Trichlorobenzene, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
1,2,4-Trichlorobenzene
- Harmful if swallowed.
- Causes skin irritation.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation occurs:
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 1,2,4-Trichlorobenzene in the GHS label constructor →
07 · Health hazards
1,2,4-Trichlorobenzene health hazards and exposure limits
1,2,4-Trichlorobenzene hazard summary
Occupational exposure to 1,2,4-trichlorobenzene may occur from inhalation during its manufacture and use. No information is available on the acute (short-term), chronic (long-term), reproductive, developmental, and carcinogenic effects of 1,2,4-trichlorobenzene in humans. Local irritation of the lungs and dyspnea have been reported in animals following acute inhalation exposure. Chronic oral exposure has been observed to result in increased adrenal weights and vacuolization of the zona fasciculata in the cortex in rats. Liver effects have also been reported following chronic oral exposure in rats. EPA has classified 1,2,4-trichlorobenzene as a Group D, not classifiable as to human carcinogenicity.
Source: EPA Hazardous Air Pollutants
1,2,4-Trichlorobenzene carcinogenicity classification
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity
Source: Hazardous Substances Data Bank (HSDB)
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Inadequate.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
1,2,4-Trichlorobenzene occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 5 ppm (40 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | C 5 ppm (40 mg/m3) | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | N.D. | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
1,2,4-Trichlorobenzene properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
1,2,4-Trichlorobenzene boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 213.5 °C (416.3 °F) | HSDB | |
| 213.33 °C (416 °F) | NIOSH | ||
| 212.78 °C (415 °F) | at 760 mmHg | CAMEO |
1,2,4-Trichlorobenzene melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 16.92 °C (62.5 °F) | HSDB | |
| 17.22 °C (63 °F) | NIOSH |
1,2,4-Trichlorobenzene density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.4483 g/cm³ | HSDB | |
| 0.447 g/cm³ | HSDB | ||
| 1.459 g/cm³ | at 20 °C | HSDB |
1,2,4-Trichlorobenzene solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Sparingly soluble in alcohol. Miscible with ether, benzene, petroleum ether, carbon disulfide | HSDB | |
| 0.003% | NIOSH | ||
| In water, 49.0 mg/L at 25 °C | at 25 °C | HSDB |
1,2,4-Trichlorobenzene vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 1 mmHg | NIOSH | |
| 0.46 mmHg | at 25 °C | HSDB | |
| 0.3 mmHg | at 25 °C | ICSC |
1,2,4-Trichlorobenzene flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 105 °C (221 °F) | HSDB | |
| 105.56 °C (222 °F) | NIOSH | ||
| 110 °C (230 °F) | CAMEO |
1,2,4-Trichlorobenzene autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 571 °C (1059.8 °F) | HSDB | |
| 571.11 °C (1060 °F) | CAMEO |
1,2,4-Trichlorobenzene lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 2.5 % by volume | DOE PAC | |
| 2.5 % by volume | at 150 °C | HSDB |
1,2,4-Trichlorobenzene upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 6.6 % by volume | at 150 °C | HSDB |
1,2,4-Trichlorobenzene vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 6.26 (air = 1) | HSDB |
1,2,4-Trichlorobenzene odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Industrial data report an odor threshold of approx 3 ppm ... | HSDB | |
| Low odor threshold= 24.0 mg/cu m; High odor threshold= 24.0 mg/cu m; Irritating concn= 40.0 mg/cu m | HSDB | ||
| Odor Threshold Low: 2.96 [ppm] | Haz-Map |
1,2,4-Trichlorobenzene critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 453.3 °C (847.9 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
1,2,4-Trichlorobenzene fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
1,2,4-Trichlorobenzene fire potential
Vapor explosion hazard indoors, outdoors, or in sewers. Runoff to sewer may creat fire or explosion hazard.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
1,2,4-Trichlorobenzene storage and handling
1,2,4-Trichlorobenzene safe storage
Separated from strong oxidants, acids and food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
1,2,4-Trichlorobenzene storage conditions
1,2,4-Trichlorobenzenes are liquids at room temperature and are shipped in bulk in aluminum tank trucks and steel or stainless steel tank cars.
Source: Hazardous Substances Data Bank (HSDB)
1,2,4-Trichlorobenzene incompatible materials
... On contact with acids or acid fumes they evolve highly toxic /hydrogen chloride/ fumes. /chlorides/
Source: Hazardous Substances Data Bank (HSDB)
1,2,4-Trichlorobenzene reactivity
1,2,4-TRICHLOROBENZENE can react vigorously with oxidizing materials (NTP, 1992). Yields hydrogen chloride and phosgene when heated to decomposition (USCG, 1999).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 1,2,4-Trichlorobenzene in the storage compatibility matrix →
11 · Questions
1,2,4-Trichlorobenzene — frequently asked questions
What is the CAS number of 1,2,4-Trichlorobenzene?
The CAS number of 1,2,4-Trichlorobenzene is 120-82-1. Its EC number is 204-428-0.
What is the chemical formula of 1,2,4-Trichlorobenzene?
The molecular formula of 1,2,4-Trichlorobenzene is C6H3Cl3 and its molecular weight is 181.4 g/mol.
What does a 1,2,4-Trichlorobenzene label have to show?
Under CLP Annex VI the label for 1,2,4-Trichlorobenzene carries the pictograms Exclamation mark and Environment and the signal word is Warning.
Is 1,2,4-Trichlorobenzene flammable?
CLP Annex VI assigns 1,2,4-Trichlorobenzene no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 105 °C (221 °F) (HSDB).
Is 1,2,4-Trichlorobenzene a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 1,2,4-Trichlorobenzene. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for 1,2,4-Trichlorobenzene?
The US occupational exposure limit reported for 1,2,4-Trichlorobenzene is none See Appendix G (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of 1,2,4-Trichlorobenzene?
The boiling point reported for 1,2,4-Trichlorobenzene is 213.5 °C (416.3 °F) (HSDB).
What is the melting point of 1,2,4-Trichlorobenzene?
The melting point reported for 1,2,4-Trichlorobenzene is 16.92 °C (62.5 °F) (HSDB).
How should 1,2,4-Trichlorobenzene be stored?
1,2,4-Trichlorobenzenes are liquids at room temperature and are shipped in bulk in aluminum tank trucks and steel or stainless steel tank cars. (Hazardous Substances Data Bank (HSDB))
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