Substance profile
1,3-propylene oxide
1,3-propylene oxide is an oil with an agreeable aromatic odor.
01 · Identification
What 1,3-propylene oxide is
1,3-propylene oxide is an oil with an agreeable aromatic odor. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. It boils at 48 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
1,3-propylene oxide identifiers and molecular data
1,3-propylene oxide CAS number and EC number
1,3-propylene oxide molecular formula and molecular weight
03 · GHS classification
1,3-propylene oxide hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
1,3-propylene oxide pictograms and signal word
1,3-propylene oxide hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Flammable liquids GHS chapter 2.6 | Category 2 | H225 | GHS02 |
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 4 | H332 | GHS07 |
1,3-propylene oxide hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H225 | Highly flammable liquid and vapour. |
| H332 | Harmful if inhaled. |
| H312 | Harmful in contact with skin. |
| H302 | Harmful if swallowed. |
This page lists only the codes assigned to 1,3-propylene oxide. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 1,3-propylene oxide
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,3-propylene oxide issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
1,3-propylene oxide precautionary statements
CLP Annex VI assigns 15 precautionary statements to 1,3-propylene oxide. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
1,3-propylene oxide name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 1,3-пропиленоксид |
| Spanish español | Óxido de 1,3-propileno |
| Czech čeština | 1,3-propylenoxid |
| Danish dansk | oxetan |
| German Deutsch | 1,3-Propylenoxid Oxetan1,3-Epoxypropan |
| Estonian eesti | 1,3-propüleenoksiid |
| Greek ελληνικά | 1,3-προπυλενοξείδιο |
| English English | 1,3-propylene oxide |
| French français | oxyde de 1,3-propylène |
| Croatian hrvatski | 1,3-propilen-oksid |
| Italian italiano | 1,3-epossipropano |
| Latvian latviešu | 1,3-propilēnoksīds |
| Lithuanian lietuvių | 1,3-propilenoksidas |
| Hungarian magyar | 1,3-propilén-oxid 1,3-epoxipropán |
| Maltese Malti | ossidu ta’ 1,3-propilen |
| Dutch Nederlands | 1,3-epoxypropaan 1,3-propyleenoxide |
| Polish polski | 1,3-epoksypropan |
| Portuguese português | óxido de 1,3-propileno |
| Romanian română | 1,3-propilen oxid |
| Slovak slovenčina | oxetán |
| Slovenian slovenščina | 1,3-propilen oksid |
| Finnish suomi | 1,3-propyleenioksidi |
| Swedish svenska | 1,3-propylenoxid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
1,3-propylene oxide GHS label elements
Everything CLP Annex VI fixes for 1,3-propylene oxide, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
1,3-propylene oxide
- Highly flammable liquid and vapour.
- Harmful if inhaled.
- Harmful in contact with skin.
- Harmful if swallowed.
- Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Keep container tightly closed.
- Use explosion-proof [electrical/ventilating/lighting/…] equipment.
- Use only non-sparking tools.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Rinse mouth.
- Wash with plenty of water/…
- Store in a well-ventilated place.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 1,3-propylene oxide in the GHS label constructor →
07 · Health hazards
1,3-propylene oxide health hazards and exposure limits
1,3-propylene oxide hazard summary
A tumorigen and a mutagen; [RTECS] May cause irritation; Harmful by inhalation, ingestion, and skin absorption; [CAMEO] An irritant; [MSDSonline]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
1,3-propylene oxide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
1,3-propylene oxide boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 48 °C (118.4 °F) | at 750 mmHg | HSDB |
| 50 °C (122 °F) | at 760 mmHg | CAMEO |
1,3-propylene oxide density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.893 g/cm³ | at 25 °C | HSDB |
1,3-propylene oxide solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | SOL IN ALL PROPORTIONS OF WATER, ALCOHOL; SOL IN ETHER; VERY SOL IN ACETONE, ORGANIC SOLVENTS | HSDB | |
| In water, miscible. | HSDB | ||
| 10 to 50 mg/mL at 68 °F (NTP, 1992) | at 20 °C | CAMEO |
1,3-propylene oxide vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 324 mmHg | at 25 °C | HSDB |
| 324 mmHg | Haz-Map |
1,3-propylene oxide flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | -28.33 °C (-19 °F) | CAMEO | |
| -28 °C (-18.4 °F) | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
1,3-propylene oxide storage and handling
1,3-propylene oxide incompatible materials
Strained ring oxygen heterocycles such as epoxides and exetanes react with the oxide in dichloromethane at sub-ambient temperatures to form high yields of the powerfully explosive glycol dinitrate esters.
Source: Hazardous Substances Data Bank (HSDB)
1,3-propylene oxide reactivity
1,3-PROPYLENE OXIDE reacts with Grignard reagents and organolithium compounds. It is also incompatible with oxidizing agents and strong acids. (NTP, 1992). An explosion occurred when propylene oxide was added to epoxy resin. Polymerization was catalyzed by amine accelerator in the resin [Bretherick 1995]. Propylene oxide and sodium hydroxide base-catalyzed the polymerization of the former, causing ignition and explosion of a drum of the crude product. [Combust Sci. Technol., 1983].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 1,3-propylene oxide in the storage compatibility matrix →
10 · Questions
1,3-propylene oxide — frequently asked questions
What is the CAS number of 1,3-propylene oxide?
The CAS number of 1,3-propylene oxide is 503-30-0. Its EC number is 207-964-3.
What is the chemical formula of 1,3-propylene oxide?
The molecular formula of 1,3-propylene oxide is C3H6O and its molecular weight is 58.08 g/mol.
What does a 1,3-propylene oxide label have to show?
Under CLP Annex VI the label for 1,3-propylene oxide carries the pictograms Flame and Exclamation mark and the signal word is Danger.
Is 1,3-propylene oxide flammable?
Yes. CLP Annex VI assigns 1,3-propylene oxide H225 — highly flammable liquid and vapour. The flash point reported for it is -28.33 °C (-19 °F) (CAMEO).
Is 1,3-propylene oxide a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 1,3-propylene oxide. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of 1,3-propylene oxide?
The boiling point reported for 1,3-propylene oxide is 48 °C (118.4 °F), at 750 mmHg (HSDB).
How should 1,3-propylene oxide be stored?
CLP Annex VI assigns 1,3-propylene oxide the storage statement P403.
Nearby
Substances next to 1,3-propylene oxide
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