Substance profile
1,4-Diaminobenzene dihydrochloride
1,4-Diaminobenzene dihydrochloride is white to slightly reddish crystals.
01 · Identification
What 1,4-Diaminobenzene dihydrochlo… is
1,4-Diaminobenzene dihydrochloride is white to slightly reddish crystals. Its molecular formula is C6H10Cl2N2 and its molecular weight is 181.06 g/mol. It melts at 275 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
1,4-Diaminobenzene dihydrochlo… identifiers and molecular data
1,4-Diaminobenzene dihydrochlo… CAS number and EC number
1,4-Diaminobenzene dihydrochlo… molecular formula and molecular weight
Other names for 1,4-Diaminobenzene dihydrochlo…
- benzene-1,4-diamine dihydrochloride
- p-phenylenediamine dihydrochloride
03 · GHS classification
1,4-Diaminobenzene dihydrochlo… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
1,4-Diaminobenzene dihydrochlo… pictograms and signal word
1,4-Diaminobenzene dihydrochlo… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
1,4-Diaminobenzene dihydrochlo… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H319 | Causes serious eye irritation. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 1,4-Diaminobenzene…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 1,4-Diaminobenzene…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,4-Diaminobenzene… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
1,4-Diaminobenzene dihydrochlo… precautionary statements
CLP Annex VI assigns 21 precautionary statements to 1,4-Diaminobenzene…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
1,4-Diaminobenzene dihydrochlo… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | бензен-1,4-диаминдихидрохлорид p -фенилендиаминдихидрохлорид |
| Spanish español | Diclorhidrato de benceno-1,4-diamina diclorhidrato de p -fenilendiamina |
| Czech čeština | benzen-1,4-diamin-dihydrochlorid p -fenylendiamin-dihydrochlorid |
| Danish dansk | benzen-1,4-diamindihydrochlorid p-phenylendiamindihydrochlorid |
| German Deutsch | Benzol-1,4-diamindihydrochlorid p -Phenylendiamindihydrochlorid |
| Estonian eesti | benseen-1,4-diamiindivesinikkloriid p -fenüleendiamiindivesinikkloriid |
| Greek ελληνικά | διυδροχλωρική βενζολο-1,4-διαμίνη διυδροχλωρική p -φαινυλενοδιαμίνη |
| English English | benzene-1,4-diamine dihydrochloride p -phenylenediamine dihydrochloride |
| French français | dichlorhydrate de benzène-1,4-diamine dichlorhydrate de p -phénylènediamine |
| Croatian hrvatski | benzen-1,4-diamin dihidroklorid p -fenilendiamin dihidroklorid |
| Italian italiano | benzen-1,4-diamina, dicloridrato p -fenilendiamina, dicloridrato |
| Latvian latviešu | benzol-1,4-diamīna dihidrohlorīds p -fenilēndiamīna dihidrohlorīds |
| Lithuanian lietuvių | benzeno-1,4-diamino vandenilio dichloridas p -fenilendiamino vandenilio dichloridas |
| Hungarian magyar | benzol-1,4-diamin-dihidroklorid p -feniléndiamin-dihidroklorid |
| Maltese Malti | diidroklorur tal-benzen-1,4-diammina p - dikloidrat tal-fenilendiammina |
| Dutch Nederlands | benzeen-1,4-diaminedihydrochloride p -fenyleendiaminedihydrochloride |
| Polish polski | dichlorek 1,4-fenylenodiamoniowy dichlorowodorek p -fenylenodiaminy |
| Portuguese português | benzeno-1,4-diamina, dicloridrato p -fenilenodiamina, dicloridrato |
| Romanian română | diclorhidrat de 1,4-diamino-benzen diclorhidrat de p -fenilen-diamină |
| Slovak slovenčina | benzén-1,4-diamónium-dichlorid dihydrochlorid para -fenyléndiamínu |
| Slovenian slovenščina | benzen-1,4-diamin dihidroklorid p -fenilendiamin dihidroklorid |
| Finnish suomi | p -fenyleenidiamiinidihydrokloridi bentseeni-1,4-diamiinidihydrokloridi |
| Swedish svenska | bensen-1,4-diamindihydroklorid p -fenylendiamindihydroklorid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
1,4-Diaminobenzene dihydrochlo… GHS label elements
Everything CLP Annex VI fixes for 1,4-Diaminobenzene…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
1,4-Diaminobenzene dihydrochlo…
- Toxic if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- Causes serious eye irritation.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation or rash occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 1,4-Diaminobenzene… in the GHS label constructor →
07 · Health hazards
1,4-Diaminobenzene dihydrochlo… health hazards and exposure limits
1,4-Diaminobenzene dihydrochlo… hazard summary
An eye irritant; Can be absorbed through skin; Can induce methemoglobinemia; May cause skin sensitization and asthma after prolonged contact; May cause kidney injury; [ICSC] The parent compound has caused allergic dermatitis and eye injury in humans; Emergency treatment: Paraphenylenediamine; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] A skin, eye, mucous membrane, and upper respiratory tract irritant; May cause asthma, skin sensitization, liver atrophy, and permanent eye injury; [CAMEO] An eye irritant; May cause skin sensitization; [eChemPortal: ESIS] A mutagen; [RTECS] See p-Phenylenediamine.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
1,4-Diaminobenzene dihydrochlo… carcinogenicity classification
Under the conditions of this bioassay, there was no convincing evidence that dietary administration of p-phenylenediamine dihydrochloride was carcinogenic in Fischer 344 rats or B6C3F1 mice.
Source: US National Toxicology Program · TR-174: Bioassay of p-Phenylenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 624-18-0) (1979 )
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
1,4-Diaminobenzene dihydrochlo… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
1,4-Diaminobenzene dihydrochlo… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 275 °C (527 °F) | ICSC | |
| 200 °C (392 °F) | above this value | CAMEO |
1,4-Diaminobenzene dihydrochlo… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | FREELY SOL IN WATER; SLIGHTLY SOL IN ALC, ETHER | HSDB | |
| Solubility in water: very good | ICSC | ||
| greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) | at 21.11 °C | CAMEO |
1,4-Diaminobenzene dihydrochlo… vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 6.2 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
1,4-Diaminobenzene dihydrochlo… storage and handling
1,4-Diaminobenzene dihydrochlo… safe storage
Separated from food and feedstuffs.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
1,4-Diaminobenzene dihydrochlo… reactivity
Acidic organic/inorganic salts, such as 1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE, are generally soluble in water. The resulting solutions contain moderate to high concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 1,4-Diaminobenzene… in the storage compatibility matrix →
10 · Questions
1,4-Diaminobenzene dihydrochlo… — frequently asked questions
What is the CAS number of 1,4-Diaminobenzene dihydrochlo…?
The CAS number of 1,4-Diaminobenzene dihydrochlo… is 624-18-0. Its EC number is 210-834-9.
What is the chemical formula of 1,4-Diaminobenzene dihydrochlo…?
The molecular formula of 1,4-Diaminobenzene dihydrochlo… is C6H10Cl2N2 and its molecular weight is 181.06 g/mol.
What does a 1,4-Diaminobenzene dihydrochlo… label have to show?
Under CLP Annex VI the label for 1,4-Diaminobenzene dihydrochlo… carries the pictograms Skull and crossbones and Environment and the signal word is Danger.
Is 1,4-Diaminobenzene dihydrochlo… flammable?
CLP Annex VI assigns 1,4-Diaminobenzene dihydrochlo… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is 1,4-Diaminobenzene dihydrochlo… a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 1,4-Diaminobenzene dihydrochlo…. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the melting point of 1,4-Diaminobenzene dihydrochlo…?
The melting point reported for 1,4-Diaminobenzene dihydrochlo… is 275 °C (527 °F) (ICSC).
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