Substance profile
1,4-Dichlorobenzene
1,4-Dichlorobenzene is white crystals with a distinctive aromatic odor becomes very strong at concentrations between 30 and.
01 · Identification
What 1,4-Dichlorobenzene is
1,4-Dichlorobenzene is white crystals with a distinctive aromatic odor becomes very strong at concentrations between 30 and. It boils at 174 °C, melts at 53.1 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
1,4-Dichlorobenzene identifiers and molecular data
1,4-Dichlorobenzene CAS number and EC number
1,4-Dichlorobenzene molecular formula and molecular weight
Other names for 1,4-Dichlorobenzene
- p-dichlorobenzene
03 · GHS classification
1,4-Dichlorobenzene hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
1,4-Dichlorobenzene pictograms and signal word
1,4-Dichlorobenzene hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
1,4-Dichlorobenzene hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H319 | Causes serious eye irritation. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 1,4-Dichlorobenzene. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 1,4-Dichlorobenzene
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,4-Dichlorobenzene issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
1,4-Dichlorobenzene precautionary statements
CLP Annex VI assigns 11 precautionary statements to 1,4-Dichlorobenzene. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
1,4-Dichlorobenzene name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 1,4-дихлоробензен p -дихлоробензен |
| Spanish español | 1,4-Diclorobenceno p -diclorobenceno |
| Czech čeština | 1,4-dichlorbenzen p -dichlorbenzen |
| Danish dansk | 1,4-dichlorbenzen para-dichlorbenzen |
| German Deutsch | 1,4-Dichlorbenzol p -Dichlorbenzol |
| Estonian eesti | 1,4-diklorobenseen p -diklorobenseen |
| Greek ελληνικά | 1,4-διχλωροβενζόλιο p -διχλωροβενζόλιο |
| English English | 1,4-dichlorobenzene p -dichlorobenzene |
| French français | 1,4-dichlorobenzène p -dichlorobenzène |
| Croatian hrvatski | 1,4-diklorbenzen p -diklorbenzen |
| Italian italiano | 1,4-diclorobenzene p -diclorobenzene |
| Latvian latviešu | 1,4-dihlorbenzols p -dihlorbenzols |
| Lithuanian lietuvių | 1,4-dichlorbenzenas p -dichlorbenzenas |
| Hungarian magyar | 1,4-diklórbenzol p -diklórbenzol |
| Maltese Malti | 1,4-diklorobenżen p -diklorobenżen |
| Dutch Nederlands | 1,4-dichloorbenzeen p -dichloorbenzeen |
| Polish polski | 1,4-dichlorobenzen p -dichlorobenzen |
| Portuguese português | 1,4-diclorobenzeno p -diclorobenzeno |
| Romanian română | 1,4-diclorobenzenă p -diclorobenzenă |
| Slovak slovenčina | 1,4-dichlórbenzén para -dichlórbenzén |
| Slovenian slovenščina | 1,4-diklorobenzen p -diklorobenzen |
| Finnish suomi | 1,4-diklooribentseeni p -diklooribentseeni |
| Swedish svenska | 1,4-diklorbensen p -diklorbensen |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
1,4-Dichlorobenzene GHS label elements
Everything CLP Annex VI fixes for 1,4-Dichlorobenzene, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
1,4-Dichlorobenzene
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes serious eye irritation.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Wash … thoroughly after handling.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF IN EYES:
- IF exposed or concerned:
- Get medical advice/attention.
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 1,4-Dichlorobenzene in the GHS label constructor →
07 · Health hazards
1,4-Dichlorobenzene health hazards and exposure limits
1,4-Dichlorobenzene hazard summary
The primary exposure to 1,4-dichlorobenzene is from breathing contaminated indoor air. Acute (short- term) exposure to 1,4-dichlorobenzene, via inhalation in humans, results in irritation of the skin, throat, and eyes. Chronic (long-term) 1,4-dichlorobenzene inhalation exposure in humans results in effects on the liver, skin, and central nervous system (CNS). No information is available on the reproductive, developmental, or carcinogenic effects of 1,4-dichlorobenzene in humans. A National Toxicology Program (NTP) study reported that 1,4-dichlorobenzene caused kidney tumors in male rats and liver tumors in both sexes of mice by gavage (experimentally placing the chemical in their stomachs). EPA has classified 1,4- dichlorobenzene as a Group C, possible human carcinogen.
Source: EPA Hazardous Air Pollutants
1,4-Dichlorobenzene carcinogenicity classification
Under the conditions of these 2-year gavage studies, 1,4-dichlorobenzene produced clear evidence of carcinogenicity for male F344/N rats, as shown by an increased incidence of renal tubular cell adenocarcinomas. There was no evidence of carcinogenicity for female F344/N rats receiving doses of 300 or 600 mg/kg. There was clear evidence of carcinogenicity for both male and female B6C3F1 mice, as shown by increased incidences of hepatocellular carcinomas and hepatocellular adenomas. Marginal increases were observed in the incidences of pheochromocytomas of the adrenal gland in male mice. Nonneoplastic effects in the kidney of male and female rats, in the liver of male and female mice, and in the thyroid gland and adrenal gland of male mice were also associated with the administration of 1,4-dichlorobenzene.
Source: US National Toxicology Program · TR-319: Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1987 )
Cancer Classification: Group C Possible Human Carcinogen
Source: Hazardous Substances Data Bank (HSDB)
1,4-Dichlorobenzene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
1,4-Dichlorobenzene occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 75.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 75 ppm (450 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 75 ppm (450 mg/m3) See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | Ca See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 150 ppm ; A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 150.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | NIOSH considers p-dichlorobenzene to be a potential occupational carcinogen. [150 ppm] | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
1,4-Dichlorobenzene properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
1,4-Dichlorobenzene boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 173.9 °C (345 °F) | HSDB | |
| 173.89 °C (345 °F) | NIOSH | ||
| 173.89 °C (345 °F) | at 760 mmHg | CAMEO |
1,4-Dichlorobenzene melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 53.1 °C (127.6 °F) | HSDB | |
| 53.33 °C (128 °F) | NIOSH | ||
| 52.78 °C (127 °F) | CAMEO |
1,4-Dichlorobenzene density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.25 g/cm³ | NIOSH | |
| 1.4581 g/cm³ | at 20.5 °C | HSDB | |
| 1.2475 g/cm³ | at 25 °C | HSDB |
1,4-Dichlorobenzene solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Practically insoluble in water | HSDB | |
| Soluble in chloroform, carbon disulfide, benzene, ether, alcohol | HSDB | ||
| In water, 81.3 mg/L at 25 °C | at 25 °C | HSDB |
1,4-Dichlorobenzene vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 1.3 mmHg | NIOSH | |
| 0.6 mmHg | at 20 °C | CAMEO | |
| 1.74 mmHg | at 25 °C | HSDB |
1,4-Dichlorobenzene flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 66 °C (150.8 °F) | HSDB | |
| 65.56 °C (150 °F) | HSDB |
1,4-Dichlorobenzene autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 500 °C (932 °F) | HSDB | |
| 640 °C (1184 °F) | ICSC |
1,4-Dichlorobenzene lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 2.5 % by volume | NIOSH | |
| 1.7 % by volume | ICSC |
1,4-Dichlorobenzene upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 5.9 % by volume | ICSC |
1,4-Dichlorobenzene vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 5.08 (air = 1) | HSDB |
1,4-Dichlorobenzene odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Odor Threshold Low: 0.12 [ppm] | Haz-Map | |
| Odor Threshold High: 15.0 [ppm] | Haz-Map | ||
| Detection odor threshold from AIHA (mean = 0.12 ppm) | Haz-Map |
1,4-Dichlorobenzene critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 395.85 °C (744.5 °F) | HSDB |
1,4-Dichlorobenzene corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | Non-corrosive | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
1,4-Dichlorobenzene storage and handling
1,4-Dichlorobenzene safe storage
Separated from strong oxidants and food and feedstuffs. Provision to contain effluent from fire extinguishing. Keep in a well-ventilated room. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
1,4-Dichlorobenzene storage conditions
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): 13: Non Combustible Solids.
Source: Hazardous Substances Data Bank (HSDB)
1,4-Dichlorobenzene incompatible materials
Incompatible materials: Oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
1,4-Dichlorobenzene reactivity
P-DICHLOROBENZENE is incompatible with oxidizing agents. It is also incompatible with aluminum and its alloys. It liquefies when mixed with camphor, phenol and salol. It will attack some forms of plastics, rubber and coatings. (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 1,4-Dichlorobenzene in the storage compatibility matrix →
10 · Questions
1,4-Dichlorobenzene — frequently asked questions
What is the CAS number of 1,4-Dichlorobenzene?
The CAS number of 1,4-Dichlorobenzene is 106-46-7. Its EC number is 203-400-5.
What does a 1,4-Dichlorobenzene label have to show?
Under CLP Annex VI the label for 1,4-Dichlorobenzene carries the pictograms Health hazard and Environment and the signal word is Warning.
Is 1,4-Dichlorobenzene flammable?
CLP Annex VI assigns 1,4-Dichlorobenzene no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 66 °C (150.8 °F) (HSDB).
Is 1,4-Dichlorobenzene a carcinogen?
CLP Annex VI assigns 1,4-Dichlorobenzene H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for 1,4-Dichlorobenzene?
The US occupational exposure limit reported for 1,4-Dichlorobenzene is 75.0 [ppm] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of 1,4-Dichlorobenzene?
The boiling point reported for 1,4-Dichlorobenzene is 173.9 °C (345 °F) (HSDB).
What is the melting point of 1,4-Dichlorobenzene?
The melting point reported for 1,4-Dichlorobenzene is 53.1 °C (127.6 °F) (HSDB).
How should 1,4-Dichlorobenzene be stored?
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): 13: Non Combustible Solids. (Hazardous Substances Data Bank (HSDB))
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