Substance profile
2,2'-bioxirane
2,2'-bioxirane is a water-white.
01 · Identification
What 2,2'-bioxirane is
2,2'-bioxirane is a water-white. It boils at 138 °C, melts at -19 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
2,2'-bioxirane identifiers and molecular data
2,2'-bioxirane CAS number and EC number
2,2'-bioxirane molecular formula and molecular weight
Other names for 2,2'-bioxirane
- 1,2:3,4-diepoxybutane
03 · GHS classification
2,2'-bioxirane hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
2,2'-bioxirane pictograms and signal word
2,2'-bioxirane hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 1A or 1B or 1C | H314 | GHS05 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 1A or 1B | H340 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
2,2'-bioxirane hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H340 | May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H330 | Fatal if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H314 | Causes severe skin burns and eye damage. |
This page lists only the codes assigned to 2,2'-bioxirane. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 2,2'-bioxirane
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 2,2'-bioxirane issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
2,2'-bioxirane precautionary statements
CLP Annex VI assigns 14 precautionary statements to 2,2'-bioxirane. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
2,2'-bioxirane name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2,2′-биоксиран 1,2:3,4-диепоксибутан |
| Spanish español | 2,2'-Bioxirano 1,2:3,4-diepoxibutano |
| Czech čeština | 2,2'- bioxiran 1,2:3,4-diepoxybutan |
| Danish dansk | 2,2'-bioxiran 1,2:3,4-diepoxybutan |
| German Deutsch | 2,2'-Bioxiran 1,2:3,4-Diepoxybutan |
| Estonian eesti | 2,2'-bioksiraan 1,2:3,4-diepoksübutaan |
| Greek ελληνικά | 2,2′-διοξιράνιο 1,2:3,4-διεποξυβουτάνιο |
| English English | 2,2'-bioxirane 1,2:3,4-diepoxybutane |
| French français | 2,2'-bioxirane 1,2:3,4-diépoxybutane |
| Croatian hrvatski | 2,2'-bioksiran 1,2:3,4-diepoksibutan |
| Italian italiano | 2,2'- biosssirano 1,2:3,4-diepossibutano |
| Latvian latviešu | 2,2′-bioksirāns 1,2:3,4-diepoksibutāns |
| Lithuanian lietuvių | 2,2'-bioksiranas l,2:3,4-diepoksibutanas |
| Hungarian magyar | 2,2'-bioxirán 1,2:3,4-diepoxibután |
| Maltese Malti | 2,2'-bijossiran 1,2:3,4-diepossibutan |
| Dutch Nederlands | 2,2'-bioxiraan 1,2:3,4-diëpoxybutaan |
| Polish polski | 2,2'-bioksiran 1,2:3,4-diepoksybutanditlenek butadienu |
| Portuguese português | 2,2'-bioxirano 1,2:3,4-diepoxibutano |
| Romanian română | 2,2′-bioxiran 1,2:3,4 -diepoxibutan |
| Slovak slovenčina | 2,2‘-bioxirán 1,2:3,4-diepoxybután |
| Slovenian slovenščina | 2,2'-bioksiran 1,2:3,4-diepoksibutan |
| Finnish suomi | 2,2'-bioksiraani 1,2:3,4-diepoksibutaani |
| Swedish svenska | 2,2'-bioxiran 1,2:3,4-diepoxibutan |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
2,2'-bioxirane GHS label elements
Everything CLP Annex VI fixes for 2,2'-bioxirane, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
2,2'-bioxirane
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Fatal if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- Causes severe skin burns and eye damage.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- Do NOT induce vomiting.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 2,2'-bioxirane in the GHS label constructor →
07 · Health hazards
2,2'-bioxirane health hazards and exposure limits
2,2'-bioxirane hazard summary
A strong skin and eye irritant; [HSDB] May cause burns; Toxic by ingestion and skin absorption; Very toxic by inhalation; [eChemPortal: ESIS] Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals. [MAK] A severe irritant; May cause burns; May cause burns to the respiratory tract after inhalation; [MSDSonline]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
2,2'-bioxirane carcinogenicity classification
The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated 1,2:3,4-diepoxybutane for carcinogenicity. According to their analysis, the weight-of-evidence for 1,2:3,4-diepoxybutane is group B2, which is based on no evidence in humans and sufficient evidence in animals. As a group B2 chemical, 1,2:3,4-diepoxybutane is considered to be probably carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
Evaluation: There is limited evidence in humans for the carcinogenicity of 1,3-butadiene. ... There is sufficient evidence in experimental animals for the carcinogenicity of 1,2:3,4-diepoxybutane. Overall evaluation: 1,3-Butadiene is probably carcinogenic to humans (Group 2A). /1,3-Butadiene/
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
2,2'-bioxirane properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
2,2'-bioxirane boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 138 °C (280.4 °F) | HSDB | |
| 143.89 °C (291 °F) | at 760 mmHg | CAMEO | |
| 137.78 °C (280 °F) | at 760 mmHg | CAMEO |
2,2'-bioxirane melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -19 °C (-2.2 °F) | HSDB | |
| 3.89 °C (39 °F) | CAMEO | ||
| 19 °C (66.2 °F) | DOE PAC |
2,2'-bioxirane density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.962 g/cm³ | HSDB | |
| 1.1157 g/cm³ | at 20 °C | CAMEO | |
| 1.113 g/cm³ | at 18 °C | CAMEO |
2,2'-bioxirane solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In water, 1X10+6 mg/l | HSDB | |
| greater than or equal to 100 mg/mL at 67.1 °F (NTP, 1992) | at 19.5 °C | CAMEO |
2,2'-bioxirane vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 3.9 mmHg | at 20 °C | HSDB |
| 16 mmHg | at 25 °C | DOE PAC |
2,2'-bioxirane flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 45.56 °C (114 °F) | CAMEO |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
2,2'-bioxirane storage and handling
2,2'-bioxirane storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
2,2'-bioxirane reactivity
D,L-1,2:3,4-DIEPOXYBUTANE is incompatible with acids, bases and oxidizing agents. Reacts with 4-(4'-nitrobenzyl)pyridine. Also reacts with alcohols, amines, phenols. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2,2'-bioxirane in the storage compatibility matrix →
10 · Questions
2,2'-bioxirane — frequently asked questions
What is the CAS number of 2,2'-bioxirane?
The CAS number of 2,2'-bioxirane is 1464-53-5. Its EC number is 215-979-1.
What does a 2,2'-bioxirane label have to show?
Under CLP Annex VI the label for 2,2'-bioxirane carries the pictograms Skull and crossbones, Health hazard and Corrosion and the signal word is Danger.
Is 2,2'-bioxirane flammable?
CLP Annex VI assigns 2,2'-bioxirane no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 45.56 °C (114 °F) (CAMEO).
Is 2,2'-bioxirane a carcinogen?
Yes. CLP Annex VI classifies 2,2'-bioxirane as a category 1A or 1B carcinogen and assigns it H350: may cause cancer.
What is the boiling point of 2,2'-bioxirane?
The boiling point reported for 2,2'-bioxirane is 138 °C (280.4 °F) (HSDB).
What is the melting point of 2,2'-bioxirane?
The melting point reported for 2,2'-bioxirane is -19 °C (-2.2 °F) (HSDB).
How should 2,2'-bioxirane be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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