Substance profile
2,2-Bis(bromomethyl)-1,3-propanediol
2,2-Bis(bromomethyl)-1,3-propanediol is needles from benzene.
01 · Identification
What 2,2-Bis(bromomethyl)-1,3-propa… is
2,2-Bis(bromomethyl)-1,3-propanediol is needles from benzene. It boils at 235 °C, melts at 113 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
2,2-Bis(bromomethyl)-1,3-propa… identifiers and molecular data
2,2-Bis(bromomethyl)-1,3-propa… CAS number and EC number
2,2-Bis(bromomethyl)-1,3-propa… molecular formula and molecular weight
Other names for 2,2-Bis(bromomethyl)-1,3-propa…
- 2,2-bis(bromomethyl) propane-1,3-diol
03 · GHS classification
2,2-Bis(bromomethyl)-1,3-propa… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
2,2-Bis(bromomethyl)-1,3-propa… pictograms and signal word
2,2-Bis(bromomethyl)-1,3-propa… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Germ cell mutagenicity GHS chapter 3.5 | Category 1A or 1B | H340 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
2,2-Bis(bromomethyl)-1,3-propa… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H340 | May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
This page lists only the codes assigned to 2,2-Bis(bromomethyl)-1,3-p…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 2,2-Bis(bromomethyl)-1,3-p…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 2,2-Bis(bromomethyl)-1… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
2,2-Bis(bromomethyl)-1,3-propa… precautionary statements
CLP Annex VI assigns 4 precautionary statements to 2,2-Bis(bromomethyl)-1,3-p…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
2,2-Bis(bromomethyl)-1,3-propa… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2,2-бис(бромометил)пропан-1,3-диол |
| Spanish español | 2,2-Bis(bromometil)propano-1,3-diol |
| Czech čeština | 2,2-bis(brommethyl)propan-1,3-diol |
| Danish dansk | 2,2-bis(brommethyl)propan-1,3-diol |
| German Deutsch | 2,2-Bis(brommethyl)propan-1,3-diol |
| Estonian eesti | 2,2-bis(bromometüül)propaan-1,3-diool |
| Greek ελληνικά | 2,2-δις(βρωμομεθυλο)προπανο-1,3-διόλη |
| English English | 2,2-bis(bromomethyl)propane-1,3-diol |
| French français | 2,2-bis(bromométhyl)propane-1,3-diol |
| Croatian hrvatski | 2,2-bis(brommetil)propan-1,3-diol |
| Italian italiano | 2,2-bis(bromometil)propano-1,3-diolo |
| Latvian latviešu | 2,2-bis(brommetil)propān-1,3-diols |
| Lithuanian lietuvių | 2,2-bis(brommetil)propan-1,3-diolis |
| Hungarian magyar | 2,2-bisz(brómmetil)propán-1,3-diol |
| Maltese Malti | 2,2-bis(bromometil)propan-1,3-diol |
| Dutch Nederlands | 2,2-bis(broommethyl)propaan-1,3-diol |
| Polish polski | 2,2-bis(bromometylo)propano-1,3-diol |
| Portuguese português | 2,2-bis(bromometil)propano-1,3-diol |
| Romanian română | 2,2-bis(bromometil)propan-1,3-diol |
| Slovak slovenčina | 2,2-bis(brómmetyl)propán-1,3-diol |
| Slovenian slovenščina | 2,2-bis(bromometil)propan-1,3-diol |
| Finnish suomi | 2,2-bis(bromimetyyli)propaani-1,3-dioli |
| Swedish svenska | 2,2-bis(brommetyl)propan-1,3-diol |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
2,2-Bis(bromomethyl)-1,3-propa… GHS label elements
Everything CLP Annex VI fixes for 2,2-Bis(bromomethyl)-1,3-p…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
2,2-Bis(bromomethyl)-1,3-propa…
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Obtain special instructions before use.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 2,2-Bis(bromomethyl)-1,3-p… in the GHS label constructor →
07 · Health hazards
2,2-Bis(bromomethyl)-1,3-propa… health hazards and exposure limits
2,2-Bis(bromomethyl)-1,3-propa… hazard summary
A skin, eye, and mucous membrane irritant; May cause liver damage and corneal injury; [CAMEO] Observations in a high-dose lifetime feeding study of rats include degenerative changes to liver and eyes, but no oncogenic reaction; A two year feeding study with rats produced increase in neoplasm frequency in various tissues and organs; [HSDB] Effects observed in 13 week oral studies with mice and rats include histopathological changes to kidneys and urinary bladder; Rats fed 100 mg/kg bw throughout their lifetime exhibited degeneration of the liver, eye, and higher frequency of thyroid retention cyst formation; No adverse effects on sperm parameters or estrous cycle observed in 13 week feeding studies with rats and mice; A decrease in female reproductive capacity was shown in a continuous breeding study with mice; Some evidence of mutagenicity; Sufficient evidence of carcinogenicity in laboratory animals; [IARC]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
2,2-Bis(bromomethyl)-1,3-propa… carcinogenicity classification
Under the conditions of these waterborne studies, 2,2-bis(bromomethyl)-1,3-propanediol at concentrations of up to 150 mg/L for 16 months was considered carcinogenic for male guppies based on increased incidences of hepatocellular adenomas or carcinomas. The study in female guppies was considered inadequate based on reduced survival. Under the conditions of these waterborne studies, 2,2-bis(bromomethyl)- 1,3-propanediol at concentrations of up to 150 mg/L for 14 months was considered carcinogenic for male medaka based on increased incidences of hepatocellular adenomas or carcinomas. The study in female medaka was considered negative.
Source: US National Toxicology Program · TR-528: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies) (2005 )
No epidemiological data relevant to the carcinogenicity of 2,2-bis(bromomethyl)propane-1,3-diol were available. There is sufficient evidence in experimental animals for the carcinogenicity of 2,2-bis(bromomethyl)propane-1,3-diol. Overall evaluation 2,2-Bis(bromomethyl)propane-1,3-diol is possibly carcinogenic to humans (Group 2B).
Source: Hazardous Substances Data Bank (HSDB)
2,2-bis-(Bromomethyl)-1,3-propanediol: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
2,2-Bis(bromomethyl)-1,3-propa… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
2,2-Bis(bromomethyl)-1,3-propa… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 235 °C (455 °F) | decomposes, at 760 mmHg | CAMEO |
2,2-Bis(bromomethyl)-1,3-propa… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 113 °C (235.4 °F) | HSDB | |
| 109.44 °C (229 °F) | range, midpoint shown | CAMEO |
2,2-Bis(bromomethyl)-1,3-propa… density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 2.2 g/cm³ | CAMEO |
2,2-Bis(bromomethyl)-1,3-propa… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In water, 38 g/L at 25 °C | at 25 °C | HSDB |
| less than 1 mg/mL at 66 °F (NTP, 1992) | at 18.89 °C | CAMEO |
2,2-Bis(bromomethyl)-1,3-propa… vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000013 mmHg | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
2,2-Bis(bromomethyl)-1,3-propa… storage and handling
2,2-Bis(bromomethyl)-1,3-propa… storage conditions
Keep container tightly closed in a dry and well-ventilated place.
Source: Hazardous Substances Data Bank (HSDB)
2,2-Bis(bromomethyl)-1,3-propa… reactivity
A brominated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2,2-Bis(bromomethyl)-1,3… in the storage compatibility matrix →
10 · Questions
2,2-Bis(bromomethyl)-1,3-propa… — frequently asked questions
What is the CAS number of 2,2-Bis(bromomethyl)-1,3-propa…?
The CAS number of 2,2-Bis(bromomethyl)-1,3-propa… is 3296-90-0. Its EC number is 221-967-7.
What does a 2,2-Bis(bromomethyl)-1,3-propa… label have to show?
Under CLP Annex VI the label for 2,2-Bis(bromomethyl)-1,3-propa… carries the pictogram Health hazard and the signal word is Danger.
Is 2,2-Bis(bromomethyl)-1,3-propa… flammable?
CLP Annex VI assigns 2,2-Bis(bromomethyl)-1,3-propa… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is 2,2-Bis(bromomethyl)-1,3-propa… a carcinogen?
Yes. CLP Annex VI classifies 2,2-Bis(bromomethyl)-1,3-propa… as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of 2,2-Bis(bromomethyl)-1,3-propa…?
The boiling point reported for 2,2-Bis(bromomethyl)-1,3-propa… is 235 °C (455 °F), decomposes, at 760 mmHg (CAMEO).
What is the melting point of 2,2-Bis(bromomethyl)-1,3-propa…?
The melting point reported for 2,2-Bis(bromomethyl)-1,3-propa… is 113 °C (235.4 °F) (HSDB).
How should 2,2-Bis(bromomethyl)-1,3-propa… be stored?
Keep container tightly closed in a dry and well-ventilated place. (Hazardous Substances Data Bank (HSDB))
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