Substance profile
2,2'-iminodiethanol
2,2'-iminodiethanol is a faintly colored, viscous liquid or deliquescent prisms with a mild, ammonia-like odor.
01 · Identification
What 2,2'-iminodiethanol is
2,2'-iminodiethanol is a faintly colored, viscous liquid or deliquescent prisms with a mild, ammonia-like odor. It boils at 269 °C, melts at 27.9 °C, is miscible with water.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
2,2'-iminodiethanol identifiers and molecular data
2,2'-iminodiethanol CAS number and EC number
2,2'-iminodiethanol molecular formula and molecular weight
Other names for 2,2'-iminodiethanol
- diethanolamine
03 · GHS classification
2,2'-iminodiethanol hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
2,2'-iminodiethanol pictograms and signal word
2,2'-iminodiethanol hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 1 | H318 | GHS05 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 2 | H373 | GHS08 |
2,2'-iminodiethanol hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H302 | Harmful if swallowed. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H315 | Causes skin irritation. |
| H318 | Causes serious eye damage. |
This page lists only the codes assigned to 2,2'-iminodiethanol. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 2,2'-iminodiethanol
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 2,2'-iminodiethanol issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
2,2'-iminodiethanol precautionary statements
CLP Annex VI assigns 15 precautionary statements to 2,2'-iminodiethanol. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
2,2'-iminodiethanol name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2,2′-иминодиетанол диетаноламин |
| Spanish español | 2,2'-Iminodietanol dietanolamina |
| Czech čeština | 2,2'-iminodiethanol diethanolamin |
| Danish dansk | 2,2'-iminodiethanol diethanolamin |
| German Deutsch | 2,2'-Iminodiethanol Diethanolamin |
| Estonian eesti | 2,2'-iminodietanool dietanoolamiin |
| Greek ελληνικά | 2,2′-ιμινοδιαιθανόλη διαιθανολαμίνη |
| English English | 2,2'-iminodiethanol diethanolamine |
| French français | 2,2'-iminodiéthanol diéthanolamine |
| Croatian hrvatski | 2,2'-iminodietanol dietanolamin |
| Italian italiano | 2,2'-iminodietanolo dietanolamina |
| Latvian latviešu | 2,2′-iminodietanols dietanolamīns |
| Lithuanian lietuvių | 2,2'-iminodietanolis dietanolaminas |
| Hungarian magyar | 2,2’-iminodietanol dietanolamin |
| Maltese Malti | 2,2'-iminodietanol dietanolammina |
| Dutch Nederlands | 2,2'-iminodiëthanol diëthanolamine |
| Polish polski | 2,2'-iminodietanol dietanoloamina |
| Portuguese português | 2,2'-iminodietanol dietanolamina |
| Romanian română | 2,2'-iminodietanol dietanolamină |
| Slovak slovenčina | 2,2'-iminodietanol dietanolamín |
| Slovenian slovenščina | 2,2'-iminodietanol dietanolamin |
| Finnish suomi | 2,2'-iminodietanoli dietanolimiini |
| Swedish svenska | 2,2'-iminodietanol dietanolamin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
2,2'-iminodiethanol GHS label elements
Everything CLP Annex VI fixes for 2,2'-iminodiethanol, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
2,2'-iminodiethanol
- Harmful if swallowed.
- May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes skin irritation.
- Causes serious eye damage.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- If skin irritation occurs:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 2,2'-iminodiethanol in the GHS label constructor →
07 · Health hazards
2,2'-iminodiethanol health hazards and exposure limits
2,2'-iminodiethanol hazard summary
Diethanolamine is used in a number of consumer products, such as shampoos, cosmetics, and pharmaceuticals. Limited information is available on the health effects of diethanolamine. Acute (short- term) inhalation exposure to diethanolamine in humans may result in irritation of the nose and throat, and dermal exposure may irritate the skin. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of diethanolamine in humans. Animal studies have reported effects on the liver, kidney, blood, and central nervous system (CNS) from chronic oral exposure to diethanolamine. The National Toxicology Program (NTP) reported an increased incidence of liver and kidney tumors in mice from dermal exposure to diethanolamine. EPA has not classified diethanolamine for carcinogenicity.
Source: EPA Hazardous Air Pollutants
2,2'-iminodiethanol carcinogenicity classification
Under the conditions of these 2-year dermal studies, there was no evidence of carcinogenic activity of diethanolamine in male F344/N rats administered 16, 32, or 64 mg/kg diethanolamine or in female F344/N rats administered 8, 16, or 32 mg/kg. There was clear evidence of carcinogenic activity of diethanolamine in male and female B6C3F1 mice based on increased incidences of liver neoplasms in males and females and increased incidences of renal tubule neoplasms in males.
Source: US National Toxicology Program · TR-478: Toxicology and Carcinogenesis Studies of Diethanolamine (CASRN 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (1999 )
Evaluation: Cancer in humans: There is inadequate evidence in humans for the carcinogenicity of diethanolamine. Cancer in experimental animals: There is sufficient evidence in experimental animals for the carcinogenicity of diethanolamine. Overall evaluation: Diethanolamine is possibly carcinogen to humans (Group 2B).
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
2,2'-iminodiethanol occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 3 ppm (15 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 3 ppm (15 mg/m3) | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | N.D. | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
2,2'-iminodiethanol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
2,2'-iminodiethanol boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 268.8 °C (515.8 °F) | HSDB | |
| 269 °C (516.2 °F) | ICSC | ||
| 268.8 °C (515.8 °F) | at 760 mmHg | DOE PAC |
2,2'-iminodiethanol melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 27.9 °C (82.2 °F) | HSDB | |
| 27.78 °C (82 °F) | NIOSH |
2,2'-iminodiethanol density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.1 g/cm³ | NIOSH | |
| 1.09 g/cm³ | liquid | ICSC | |
| 1.0966 g/cm³ | at 20 °C | HSDB |
2,2'-iminodiethanol solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Very soluble in water, ethanol; slightly soluble in ethyl ether, benzene | HSDB | |
| Miscible (1X10+6 mg/L) with water at 20 °C | at 20 °C | HSDB |
2,2'-iminodiethanol vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.00028 mmHg | at 25 °C | HSDB |
| 0.01 mmHg | below this value | NIOSH |
2,2'-iminodiethanol flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 134 °C (273.2 °F) | Open cup | HSDB |
| 172.22 °C (342 °F) | HSDB | ||
| 137.22 °C (279 °F) | NIOSH |
2,2'-iminodiethanol autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 662.22 °C (1224 °F) | HSDB | |
| 662 °C (1223.6 °F) | ICSC |
2,2'-iminodiethanol lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 1.6 % by volume | calculated | HSDB |
| 1.6 % by volume | NIOSH |
2,2'-iminodiethanol upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 9.8 % by volume | estimated | HSDB |
| 9.8 % by volume | NIOSH |
2,2'-iminodiethanol vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 3.65 (air = 1) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
2,2'-iminodiethanol fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
2,2'-iminodiethanol fire potential
Combustile, when exposed to heat or flame; can react with oxidizing materials.
Source: Hazardous Substances Data Bank (HSDB)
Solubility
Miscible with methanol. acetone, alcohol, chloroform, glycerin. Solubility at 25 °C in benzene: 4.2%; in ether: 0.8%; in carbon tetrachloride: <0.1%; in heptane: <0.1%. Slightly soluble to insoluble in petroleum ether.
Source: HSDB
10 · Handling and storage
2,2'-iminodiethanol storage and handling
2,2'-iminodiethanol safe storage
Separated from strong oxidants and acids. Dry.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
2,2'-iminodiethanol storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Air sensitive.
Source: Hazardous Substances Data Bank (HSDB)
2,2'-iminodiethanol incompatible materials
DEA (Diethanolamine) degrades in the presense of carbon dioxide to yield HEOD [3-(2-hydroxy-ethyl)oxazolidone], THEED [N,N,N,'-(2-hydroxyethyl)ethyleen-diamine] and BHEP [N,N'-bis(2-hydroxyethyl)piperazine.
Source: Hazardous Substances Data Bank (HSDB)
2,2'-iminodiethanol reactivity
DIETHANOLAMINE is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. This compound is hygroscopic. It may be sensitive to exposure to air and light. This compound can react with oxidizing materials, acids, CO2, copper alloys, aluminum, zinc, galvanized iron and copper. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2,2'-iminodiethanol in the storage compatibility matrix →
11 · Questions
2,2'-iminodiethanol — frequently asked questions
What is the CAS number of 2,2'-iminodiethanol?
The CAS number of 2,2'-iminodiethanol is 111-42-2. Its EC number is 203-868-0.
What does a 2,2'-iminodiethanol label have to show?
Under CLP Annex VI the label for 2,2'-iminodiethanol carries the pictograms Health hazard, Corrosion and Exclamation mark and the signal word is Danger.
Is 2,2'-iminodiethanol flammable?
CLP Annex VI assigns 2,2'-iminodiethanol no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 134 °C (273.2 °F), Open cup (HSDB).
Is 2,2'-iminodiethanol a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for 2,2'-iminodiethanol. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for 2,2'-iminodiethanol?
The US occupational exposure limit reported for 2,2'-iminodiethanol is none See Appendix G (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of 2,2'-iminodiethanol?
The boiling point reported for 2,2'-iminodiethanol is 268.8 °C (515.8 °F) (HSDB).
What is the melting point of 2,2'-iminodiethanol?
The melting point reported for 2,2'-iminodiethanol is 27.9 °C (82.2 °F) (HSDB).
How should 2,2'-iminodiethanol be stored?
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Air sensitive. (Hazardous Substances Data Bank (HSDB))
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