Substance profile
4,4'-Thiodianiline
4,4'-Thiodianiline is needles (from water).
01 · Identification
What 4,4'-Thiodianiline is
4,4'-Thiodianiline is needles (from water). Its molecular formula is C12H12N2S and its molecular weight is 216.3 g/mol. It melts at 109 °C, is soluble in water.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
4,4'-Thiodianiline identifiers and molecular data
4,4'-Thiodianiline CAS number and EC number
4,4'-Thiodianiline molecular formula and molecular weight
Other names for 4,4'-Thiodianiline
- 4,4'-thiodianiline and its salts
03 · GHS classification
4,4'-Thiodianiline hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
4,4'-Thiodianiline pictograms and signal word
4,4'-Thiodianiline hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
4,4'-Thiodianiline hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to 4,4'-Thiodianiline. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 4,4'-Thiodianiline
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 4,4'-Thiodianiline issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
4,4'-Thiodianiline precautionary statements
CLP Annex VI assigns 11 precautionary statements to 4,4'-Thiodianiline. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
4,4'-Thiodianiline name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4,4′-тиодианилин и негови соли |
| Spanish español | 4,4'-Tiodianilina y sus sales |
| Czech čeština | 4,4'-sulfandiyldianilin a jeho soli |
| Danish dansk | 4,4'-thiodianilin salte heraf |
| German Deutsch | 4,4'-Thiodianilin und seine Salze |
| Estonian eesti | 4,4′-tiodianiliin ja selle soolad |
| Greek ελληνικά | 4,4′-θειοδιανιλίνη και τα άλατά της |
| English English | 4,4'-thiodianiline and its salts |
| French français | 4,4'-thiodianiline et ses sels |
| Croatian hrvatski | 4,4'-tiodianilin i njegove soli |
| Italian italiano | 4,4'-tiodianilina e suoi sali |
| Latvian latviešu | 4,4′-tiodianilīns un tā sāļi |
| Lithuanian lietuvių | 4,4'-tiodianilinas ir jo druskos |
| Hungarian magyar | 4,4’-tiodianilin és sói |
| Maltese Malti | 4,4'-tijodianilina u l-melħiet tagħha |
| Dutch Nederlands | 4,4'-thiodianiline [1] en zijn zouten This language edition of Annex VI files more than one substance under this single entry, so the cell is reproduced as printed: the [1] [2] markers say which name belongs to which member, and the members carry different CAS numbers. |
| Polish polski | 4,4'-tiodianilina i jej sole |
| Portuguese português | 4,4'-tiodianilina e sais de 4,4'-tiodianilina |
| Romanian română | 4,4'-tiodianilină și sărurile sale |
| Slovak slovenčina | 4,4'-sulfándiyldianilín a jeho soli |
| Slovenian slovenščina | 4,4'-tiodianilin in njegove soli |
| Finnish suomi | 4,4’-tiodianiliini ja sen suolat |
| Swedish svenska | 4,4'-tiodianilin och dess salter |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Where a cell is shown exactly as printed, the note beside it says why. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
4,4'-Thiodianiline GHS label elements
Everything CLP Annex VI fixes for 4,4'-Thiodianiline, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
4,4'-Thiodianiline
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 4,4'-Thiodianiline in the GHS label constructor →
07 · Health hazards
4,4'-Thiodianiline health hazards and exposure limits
4,4'-Thiodianiline hazard summary
Induces tumors in experimental animals in high-dose feeding studies; [HSDB]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
4,4'-Thiodianiline carcinogenicity classification
Studied by the US National Toxicology Program: TR-047: Bioassay of 4,4'-Thiodianiline for Possible Carcinogenicity (CASRN 139-65-1) (1978 )
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
4,4'-Thiodianiline: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
4,4'-Thiodianiline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
4,4'-Thiodianiline melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 108.5 °C (227.3 °F) | HSDB | |
| 108.33 °C (227 °F) | range, midpoint shown | CAMEO |
4,4'-Thiodianiline solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Very soluble in ethanol, diethyl ether, benzene; soluble in trifluoroacetic acid | HSDB | |
| Soluble in aqueous hydrochloric acid | HSDB | ||
| Slightly soluble in water | HSDB |
4,4'-Thiodianiline vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.0000111 mmHg | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
4,4'-Thiodianiline storage and handling
4,4'-Thiodianiline storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
4,4'-Thiodianiline reactivity
4,4'-THIODIANILINE is incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. May generate heat with these materials and hydrogen gas or hydrogen sulfide gas. May liberate hydrogen sulfide if heated to decomposition or mixed with an acid. Also incompatible with peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4,4'-Thiodianiline in the storage compatibility matrix →
10 · Questions
4,4'-Thiodianiline — frequently asked questions
What is the CAS number of 4,4'-Thiodianiline?
The CAS number of 4,4'-Thiodianiline is 139-65-1. Its EC number is 205-370-9.
What is the chemical formula of 4,4'-Thiodianiline?
The molecular formula of 4,4'-Thiodianiline is C12H12N2S and its molecular weight is 216.3 g/mol.
What does a 4,4'-Thiodianiline label have to show?
Under CLP Annex VI the label for 4,4'-Thiodianiline carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Danger.
Is 4,4'-Thiodianiline flammable?
CLP Annex VI assigns 4,4'-Thiodianiline no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is 4,4'-Thiodianiline a carcinogen?
Yes. CLP Annex VI classifies 4,4'-Thiodianiline as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the melting point of 4,4'-Thiodianiline?
The melting point reported for 4,4'-Thiodianiline is 108.5 °C (227.3 °F) (HSDB).
How should 4,4'-Thiodianiline be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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