Substance profile
7-oxa-3-oxiranylbicyclo [4.1.0]heptane
7-oxa-3-oxiranylbicyclo [4.1.0]heptane is a colorless liquid.
01 · Identification
What 7-oxa-3-oxiranylbicyclo… is
7-oxa-3-oxiranylbicyclo [4.1.0]heptane is a colorless liquid. Its molecular formula is C8H12O2 and its molecular weight is 140.18 g/mol. It boils at 227 °C, melts at -109 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
7-oxa-3-oxiranylbicyclo… identifiers and molecular data
7-oxa-3-oxiranylbicyclo… CAS number and EC number
7-oxa-3-oxiranylbicyclo… molecular formula and molecular weight
Other names for 7-oxa-3-oxiranylbicyclo…
- 1,2-epoxy- 4-epoxyethylcyclohexane
- 4-vinylcyclohexene diepoxide
03 · GHS classification
7-oxa-3-oxiranylbicyclo… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
7-oxa-3-oxiranylbicyclo… pictograms and signal word
7-oxa-3-oxiranylbicyclo… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 3 | H331 | GHS06 |
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
7-oxa-3-oxiranylbicyclo… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H360F | May damage fertility. |
| H331 | Toxic if inhaled. |
| H302 | Harmful if swallowed. |
This page lists only the codes assigned to 7-oxa-3-oxiranylbicyclo…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for 7-oxa-3-oxiranylbicyclo…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 7-oxa-3-oxiranylbicycl… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
7-oxa-3-oxiranylbicyclo… precautionary statements
CLP Annex VI assigns 12 precautionary statements to 7-oxa-3-oxiranylbicyclo…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
7-oxa-3-oxiranylbicyclo… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 7-окса-3-оксиранилбицикло[4.1.0]хептан 1,2-епокси-4-епоксиетилциклохексан4-винилциклохексен диепоксид |
| Spanish español | 7-Oxa-3-oxiranilbiciclo[4.1.0]heptano 1,2-epoxi-4-epoxietilciclohexanodiepóxido de 4-vinilciclohexeno |
| Czech čeština | 7-oxa-3-oxiranylbicyklo[4.1.0]heptan 1,2-epoxy-4-(1,2-epoxyethyl)cyklohexan 4-vinylcyklohexendiepoxid |
| Danish dansk | 7-oxa-3-oxiranylbicyclo[4.1.0]heptan 1,2-epoxy-4-epoxyethylcyclohexan4-vinylcyclohexendiepoxid |
| German Deutsch | 7-Oxa-3-oxiranylbicyclo[4.1.0]heptan 1,2-Epoxy-4-epoxyethylcyclohexan4-Vinylcyclohexendiepoxid |
| Estonian eesti | 7-oksa-3-oksiranüülbitsüklo[4.1.0]heptaan 1,2-epoksü-4-epoksüetüültsükloheksaan4-vinüültsüklohekseendiepoksiid |
| Greek ελληνικά | 7-οξα-3-οξιρανυλοδικυκλο[4.1.0]επτάνιο 1,2-εποξυ-4-εποξυαιθυλοκυκλοεξάνιοδιεποξείδιο του 4-βινυλοκυκλοεξενίου |
| English English | 7-oxa-3-oxiranylbicyclo[4.1.0]heptane 1,2-epoxy-4-epoxyethylcyclohexane4-vinylcyclohexene diepoxide |
| French français | 7-oxa-3-oxiranylbicyclo[4.1.0]heptane 1,2-époxy-4-époxyéthylcyclohexanediépoxyde de 4-vinylcyclohexène |
| Croatian hrvatski | 7-oks-3-oksiranilbiciklo[4.1.0]heptan 1,2-epoksi-4-epoksietilcikloheksan4-vinilcikloheksen diepoksid |
| Italian italiano | 7-ossa-3-ossiranilbiciclo[4.1.0]eptano 1,2-epossi-4-epossietilcicloesano4-vinilcicloesano diepossido |
| Latvian latviešu | 7-oksa-3-oksiranilbiciklo[4.1.0]heptāns 1,2-epoksi-4-epoksietilcikloheksāns4-vinilcikloheksēna diepoksīds |
| Lithuanian lietuvių | 7-oksa-3-oksiranilbiciklo[4.1.0]heptanas 1,2-epoksi-4-epoksietilcikloheksanas4-vinilciklohekseno diepoksidas |
| Hungarian magyar | 7-oxa-3-oxiranilbiciklo[4.1.0]heptán 1,2-epoxi-4-epoxietilciklohexán4-vinilciklohexán-diepoxid |
| Maltese Malti | 7-ossa-3-ossiranilbiċiklo[4.1.0]ettan 1,2-epossi-4-epossietilċikloeżandiepossidu ta’ 4-vinilċikloeżen |
| Dutch Nederlands | 7-oxa-3-oxiranylbicyclo[4.1.0]heptaan 1,2-epoxy-4-epoxyethylcyclohexaan4-vinylcyclohexeendiëpoxide |
| Polish polski | 7-oksa-3-oksiranylobicyklo[4.1.0]heptan 1,2-epoksy-4-epoksyetylocykloheksandiepoksy-4-winylocykloheksen |
| Portuguese português | 7-oxa-3-oxiranilbiciclo[4.1.0]heptano 1,2-epoxi-4-epoxietilciclo-hexanodiepóxido de 4-vinilciclo-hexeno |
| Romanian română | 7-oxa-3-oxiranilbiciclo [4.1.0] heptan 1,2-epoxi-4-epoxietilciclohexandiepoxid de 4-vinilciclohexen |
| Slovak slovenčina | 7-oxa-3-oxiranylbicyklo[4.1.0]heptán, 1,2-epoxy-4-epoxyetylcyklohexán, 4-vinylcyklohexén diepoxid |
| Slovenian slovenščina | 7-oksa-3-oksiranilbiciklo[4.1.0]heptan 1,2-epoksi-4-epoksietilcikloheksan4-vinilcikloheksen diepoksid |
| Finnish suomi | 7-oksa-3-oksiranyylibisyklo[4.1.0]heptaani 1,2-epoksi-4-epoksietyylisykloheksaani4-vinyylisyklohekseenidiepoksidi |
| Swedish svenska | 7-oxa-3-oxiranylbicyklo[4.1.0]heptan 1,2-epoxi-4-epoxietylcyklohexan4-vinylcyklohexendiepoxid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
7-oxa-3-oxiranylbicyclo… GHS label elements
Everything CLP Annex VI fixes for 7-oxa-3-oxiranylbicyclo…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
7-oxa-3-oxiranylbicyclo…
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May damage fertility.
- Toxic if inhaled.
- Harmful if swallowed.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF INHALED:
- IF exposed or concerned:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open 7-oxa-3-oxiranylbicyclo… in the GHS label constructor →
07 · Health hazards
7-oxa-3-oxiranylbicyclo… health hazards and exposure limits
7-oxa-3-oxiranylbicyclo… hazard summary
A potential skin sensitizer; [HSDB] VCD causes male and female reproductive damage in high-dose animal studies. [ACGIH] May cause respiratory tract irritation and pulmonary edema; May cause kidney injury; [ICSC]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
7-oxa-3-oxiranylbicyclo… carcinogenicity classification
Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of hexachloroethane for male F344/N rats, based on the increased incidences of renal neoplasms. The marginally increased incidences of pheochromocytomas of the adrenal gland may have been related to hexachloroethane administration to male rats. There was no evidence of carcinogenic activity of hexachloroethane for female F344/N rats administered 80 or 160 mg/kg by gavage for 103 weeks.
Source: US National Toxicology Program · TR-362: Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CASRN 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (1989 )
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 4-vinylcyclohexene diepoxide. There is sufficient evidence in experimental animals for the carcinogenicity of 4-vinylcyclohexene diepoxide. Overall evaluation: 4-Vinylcyclohexene diepoxide is possibly carcinogenic to humans (Group 2B).
Source: Hazardous Substances Data Bank (HSDB)
4-Vinyl-1-cyclohexene Diepoxide: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
7-oxa-3-oxiranylbicyclo… occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 10 ppm (60 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | Ca TWA 10 ppm (60 mg/m3) [skin] See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | NIOSH considers vinyl cyclohexene to be a potential occupational carcinogen. | Hazardous Substances Data Bank (HSDB) |
| IDLH | Ca [N.D.] | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
7-oxa-3-oxiranylbicyclo… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
7-oxa-3-oxiranylbicyclo… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 227 °C (440.6 °F) | at 760 mmHg | HSDB |
| 227.22 °C (441 °F) | NIOSH | ||
| 227.22 °C (441 °F) | at 760 mmHg | CAMEO |
7-oxa-3-oxiranylbicyclo… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -108.89 °C (-164 °F) | NIOSH | |
| -55 °C (-67 °F) | below this value | HSDB |
7-oxa-3-oxiranylbicyclo… density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.1 g/cm³ | NIOSH | |
| 1.0986 g/cm³ | at 20 °C | HSDB |
7-oxa-3-oxiranylbicyclo… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | SOL IN WATER | HSDB | |
| High | NIOSH | ||
| 50 to 100 mg/mL at 72 °F (NTP, 1992) | at 22.22 °C | CAMEO |
7-oxa-3-oxiranylbicyclo… vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.1 mmHg | NIOSH | |
| 0.1 mmHg | at 20 °C | CAMEO |
7-oxa-3-oxiranylbicyclo… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 110 °C (230 °F) | NIOSH |
7-oxa-3-oxiranylbicyclo… autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 393 °C (739.4 °F) | ICSC |
7-oxa-3-oxiranylbicyclo… lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Class IIIB Combustible Liquid: Fl.P. at or above 200 °F. | NIOSH |
7-oxa-3-oxiranylbicyclo… vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 4.07 (air = 1) | CAMEO | |
| 4.8 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
7-oxa-3-oxiranylbicyclo… fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
7-oxa-3-oxiranylbicyclo… fire potential
Slight, when exposed to heat or flame.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
7-oxa-3-oxiranylbicyclo… storage and handling
7-oxa-3-oxiranylbicyclo… safe storage
Separated from food and feedstuffs, alcohols, amines and other active hydrogen compounds. Dry. Ventilation along the floor.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
7-oxa-3-oxiranylbicyclo… incompatible materials
Alcohols, amines, water [Note: Slowly hydrolyzes in water].
Source: Hazardous Substances Data Bank (HSDB)
7-oxa-3-oxiranylbicyclo… reactivity
1-VINYL-3-CYCLOHEXENE DIOXIDE reacts with active hydrogen compounds (such as alcohols and amines). (NTP, 1992). Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 7-oxa-3-oxiranylbicyclo… in the storage compatibility matrix →
11 · Questions
7-oxa-3-oxiranylbicyclo… — frequently asked questions
What is the CAS number of 7-oxa-3-oxiranylbicyclo…?
The CAS number of 7-oxa-3-oxiranylbicyclo… is 106-87-6. Its EC number is 203-437-7.
What is the chemical formula of 7-oxa-3-oxiranylbicyclo…?
The molecular formula of 7-oxa-3-oxiranylbicyclo… is C8H12O2 and its molecular weight is 140.18 g/mol.
What does a 7-oxa-3-oxiranylbicyclo… label have to show?
Under CLP Annex VI the label for 7-oxa-3-oxiranylbicyclo… carries the pictograms Health hazard and Skull and crossbones and the signal word is Danger.
Is 7-oxa-3-oxiranylbicyclo… flammable?
CLP Annex VI assigns 7-oxa-3-oxiranylbicyclo… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 110 °C (230 °F) (NIOSH).
Is 7-oxa-3-oxiranylbicyclo… a carcinogen?
Yes. CLP Annex VI classifies 7-oxa-3-oxiranylbicyclo… as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the exposure limit for 7-oxa-3-oxiranylbicyclo…?
The US occupational exposure limit reported for 7-oxa-3-oxiranylbicyclo… is none See Appendix G (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of 7-oxa-3-oxiranylbicyclo…?
The boiling point reported for 7-oxa-3-oxiranylbicyclo… is 227 °C (440.6 °F), at 760 mmHg (HSDB).
What is the melting point of 7-oxa-3-oxiranylbicyclo…?
The melting point reported for 7-oxa-3-oxiranylbicyclo… is -108.89 °C (-164 °F) (NIOSH).
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