Substance profile
Azinphos-Methyl
Azinphos-Methyl is yellowish crystals and is odorless.
01 · Identification
What Azinphos-Methyl is
Azinphos-Methyl is yellowish crystals and is odorless. Its molecular formula is C10H12N3O3PS2 and its molecular weight is 317.3 g/mol. It melts at 72.8 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Azinphos-Methyl identifiers and molecular data
Azinphos-Methyl CAS number and EC number
Azinphos-Methyl molecular formula and molecular weight
Other names for Azinphos-Methyl
- azinphos-methyl (ISO)
- O,O-dimethyl-4-oxobenzotriazin-3-ylmethyl phosphorodithioate
03 · GHS classification
Azinphos-Methyl hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Azinphos-Methyl pictograms and signal word
Azinphos-Methyl hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 1 or 2 | H300 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Azinphos-Methyl hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H330 | Fatal if inhaled. |
| H300 | Fatal if swallowed. |
| H311 | Toxic in contact with skin. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Azinphos-Methyl. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Azinphos-Methyl
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Azinphos-Methyl issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Azinphos-Methyl precautionary statements
CLP Annex VI assigns 17 precautionary statements to Azinphos-Methyl. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Azinphos-Methyl name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | азинфос-метил (ISO) O , O -диметил-4-оксобензотриазин-3-илметилов фосфородитиоат |
| Spanish español | Azinfós-metilo (ISO) ditiofosfato de O, O -dimetilo y 4-oxobenzotriazin-3-ilmetilo |
| Czech čeština | azinfos-methyl (ISO) O, O -dimethyl- S -[(4(3 H )-oxo-1,2,3-benzotriazin-3-yl)methyl]-fosforodithioát |
| Danish dansk | azinphos-methyl (ISO) O, O- dimethyl-4-oxobenzotriazin-3-ylmethyldithiophosphat |
| German Deutsch | Azinphos-methyl (ISO) O , O -Dimethyl-4-oxobenzotriazin-3-ylmethylphosphorodithioat |
| Estonian eesti | metüülasiinfoss (ISO) O , O -dimetüül-4-oksobensotriasiin-3-üülmetüülfosforoditioaat |
| Greek ελληνικά | azinphos-methyl (μεθυλικό αζινφός) (ISO) διθειοφωσφορικό O , O -διμεθυλο-4-οξοβενζοτριαζιν-3-υλομεθύλιο |
| English English | azinphos-methyl (ISO) O , O -dimethyl-4-oxobenzotriazin-3-ylmethyl phosphorodithioate |
| French français | azinphos-méthyl (ISO) phosphorodithioate de O , O -diméthyl-4-oxobenzotriazin-3-ylméthyle |
| Croatian hrvatski | azinfos-metil (ISO) O , O -dimetil-4-oksobenzotriazin-3-il-metil-fosforoditioat |
| Italian italiano | azinfos-metil (ISO) ditiofosfato di O, O-dimetile e ossobenzotriazin-3-ilmetile |
| Latvian latviešu | azinfosmetils (ISO) O , O -dimetil-4-oksobenzotriazīn-3-ilmetilfosforditioāts |
| Lithuanian lietuvių | azinfos-metilas (ISO) O , O -dimetil-4-oksobenztriazin-3-ilmetilditiofosfatas |
| Hungarian magyar | azinfosz-metil (ISO) O , O -dimetil-4-oxobenzotriazin-3-ilmetil-ditiofoszfát |
| Maltese Malti | ażinfos-metil (ISO) fosforoditijoat ta O , O -dimetil-4-ossobenżotriażin-3-ilmetil |
| Dutch Nederlands | azinfos-methyl (ISO) O , O -dimethyl-4-oxobenzotriazine-3-ylmethyldithiofosfaat |
| Polish polski | azynofos metylowy (ISO) ditiofosforan O , O -dimetylu- S -(4-okso-3,4-dihydrobenzeno[d]-1,2,3-triazyn-3-ylo)metylu |
| Portuguese português | azinfos-metilo (ISO) ditiofosfato de O , O -dimetilo e de 4-oxobenzotriazin-3-ilmetilo |
| Romanian română | azinfos-metil (ISO) ditiofosfat de O, O -dimetil și de 4-oxobenzotriazin-3-ilmetil |
| Slovak slovenčina | azinfos-metyl (ISO) O, O -dimetyl- S -(4-oxo[1,2,3]benzotriazín-3- ylmetyl)-fosforoditioát |
| Slovenian slovenščina | azinfos-metil (ISO) O , O -dimetil-4-oksobenzotriazin-3-ilmetil fosforoditioat |
| Finnish suomi | atsinfossimetyyli (ISO) O , O -dimetyyli-4-oksobentsotriatsin-3-yylimetyylifosforoditioaatti |
| Swedish svenska | azinfosmetyl (ISO) O , O -dimetyl-4-oxobensotriazin-3-ylmetylfosforditioat |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Azinphos-Methyl GHS label elements
Everything CLP Annex VI fixes for Azinphos-Methyl, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Azinphos-Methyl
- Fatal if inhaled.
- Fatal if swallowed.
- Toxic in contact with skin.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- If skin irritation or rash occurs:
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Azinphos-Methyl in the GHS label constructor →
07 · Health hazards
Azinphos-Methyl health hazards and exposure limits
Azinphos-Methyl hazard summary
Guthion, also called azinphos-methyl, is an organophosphorous pesticide that was used on many crops, especially apples, pears, cherries, peaches, almonds, and cotton. Many of its former uses have been cancelled by the EPA, and its few remaining uses are currently in the process of being phased out. Guthion is a synthetic substance, it does not occur naturally. Pure guthion is a colorless to white odorless crystalline solid that melts at about 72-74ºC (162-165ºF). Technical-grade guthion is a cream to yellow-brown granular solid. Guthion is poorly soluble in water.
Source: Agency for Toxic Substances and Disease Registry (ATSDR)
Azinphos-Methyl carcinogenicity classification
Studied by the US National Toxicology Program: TR-069: Bioassay of Azinphosmethyl for Possible Carcinogenicity (CASRN 86-50-0) (1978 )
Cancer Classification: Not Likely to be Carcinogenic to Humans
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Azinphos-Methyl occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 0.2 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 0.2 mg/m³ | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 0.2 mg/m3 [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 0.2 mg/m³ | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 0.2 mg/m3 [skin] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 10 mg/m3 (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 10.0 [mg/m3] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 10 mg/cu m | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Azinphos-Methyl properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Azinphos-Methyl boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | Decomposes | decomposes | NIOSH |
| Decomposes (NTP, 1992) | decomposes | CAMEO | |
| decomposes | decomposes | OSHA |
Azinphos-Methyl melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 72.78 °C (163 °F) | NIOSH | |
| 74 °C (165.2 °F) | DOE PAC |
Azinphos-Methyl density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.44 g/cm³ | NIOSH | |
| 1.44 g/cm³ | at 20 °C | HSDB |
Azinphos-Methyl solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in methanol, ethanol, and propylene glycol, xylene, other organic solvents. | HSDB | |
| In toluene, dichloromethane, >20 g/L | HSDB |
Azinphos-Methyl vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 8e-9 mmHg | NIOSH | |
| 2e-7 mmHg | at 20 °C | HSDB |
Azinphos-Methyl lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Noncombustible solid | NIOSH |
Azinphos-Methyl odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Detection: 0.0002 mg/kg water | HSDB |
Azinphos-Methyl corrosivity
| Property | Value | Conditions | Source |
|---|---|---|---|
| Corrosivity | Non-corrosive | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Source notes
Further notes on Azinphos-Methyl
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Solubility
In dichloroethane, acetone, acetonitrile, ethyl acetate, and dimethyl sulfoxide, the solubility is >250 g/L at 20 °C; n-heptane, 1.2 g/L at 20 °C; xylene, 170 g/L at 20 °C
Source: HSDB
10 · Handling and storage
Azinphos-Methyl storage and handling
Azinphos-Methyl safe storage
Separated from food and feedstuffs. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Azinphos-Methyl storage conditions
Store in a cool dry area, away from excessive heat or open flame. Store 2L formulation above 45 °F; others above 32 °F. Store in an area designated specifically for pesticides.
Source: Hazardous Substances Data Bank (HSDB)
Azinphos-Methyl incompatible materials
Incompatibilities: Contact with strong oxidizers may cause fires and explosions.
Source: Hazardous Substances Data Bank (HSDB)
Azinphos-Methyl reactivity
The BPS Pesticide incident in Helena resulted in an explosion and death of three firemen. The burning of a 1,000 pound sack of Azinphos Methyl or the flashing of Maneb which was present on the facility may have caused the explosion. Azinphos Ethyl may behave similarly. At elevated temperatures, it will decompose generating toxic gases.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Azinphos-Methyl in the storage compatibility matrix →
11 · Questions
Azinphos-Methyl — frequently asked questions
What is the CAS number of Azinphos-Methyl?
The CAS number of Azinphos-Methyl is 86-50-0. Its EC number is 201-676-1.
What is the chemical formula of Azinphos-Methyl?
The molecular formula of Azinphos-Methyl is C10H12N3O3PS2 and its molecular weight is 317.3 g/mol.
What does a Azinphos-Methyl label have to show?
Under CLP Annex VI the label for Azinphos-Methyl carries the pictograms Skull and crossbones and Environment and the signal word is Danger.
Is Azinphos-Methyl flammable?
CLP Annex VI assigns Azinphos-Methyl no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Azinphos-Methyl a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Azinphos-Methyl. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for Azinphos-Methyl?
The US occupational exposure limit reported for Azinphos-Methyl is 0.2 [mg/m3] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Azinphos-Methyl?
The boiling point reported for Azinphos-Methyl is Decomposes, decomposes (NIOSH).
What is the melting point of Azinphos-Methyl?
The melting point reported for Azinphos-Methyl is 72.78 °C (163 °F) (NIOSH).
How should Azinphos-Methyl be stored?
Store in a cool dry area, away from excessive heat or open flame. Store 2L formulation above 45 °F; others above 32 °F. Store in an area designated specifically for pesticides. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Azinphos-Methyl
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