Substance profile
Biphenyl-4-ylamine
Biphenyl-4-ylamine is colorless crystals with a floral odor.
01 · Identification
What Biphenyl-4-ylamine is
Biphenyl-4-ylamine is colorless crystals with a floral odor. Its molecular formula is C12H11N and its molecular weight is 169.22 g/mol. It boils at 302 °C, melts at 51 °C, is slightly soluble in water.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
Biphenyl-4-ylamine identifiers and molecular data
Biphenyl-4-ylamine CAS number and EC number
Biphenyl-4-ylamine molecular formula and molecular weight
Other names for Biphenyl-4-ylamine
- xenylamine
- 4-aminobiphenyl
03 · GHS classification
Biphenyl-4-ylamine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Biphenyl-4-ylamine pictograms and signal word
Biphenyl-4-ylamine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Biphenyl-4-ylamine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
This page lists only the codes assigned to Biphenyl-4-ylamine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Biphenyl-4-ylamine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Biphenyl-4-ylamine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Biphenyl-4-ylamine precautionary statements
CLP Annex VI assigns 8 precautionary statements to Biphenyl-4-ylamine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Biphenyl-4-ylamine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | бифенил-4-иламин ксениламин4-аминобифенил |
| Spanish español | Bifenil-4-ilamina xenilamina4-aminobifenilo |
| Czech čeština | bifenyl-4-ylamin xenylamin 4-aminobifenyl |
| Danish dansk | biphenyl-4-ylamin xenylamin4-aminobiphenyl |
| German Deutsch | Biphenyl-4-ylamin Xenylamin4-Aminobiphenyl |
| Estonian eesti | bifenüül-4-üülamiin ksenüülamiin4-aminobifenüül |
| Greek ελληνικά | διφαινυλ-4-υλαμίνη ξενυλαμίνη4-αμινοδιφαινύλιο |
| English English | biphenyl-4-ylamine xenylamine4-aminobiphenyl |
| French français | biphényl-4-ylamine xénylamine4-aminobiphényle |
| Croatian hrvatski | bifenil-4-ilamin ksenilamin4-aminobifenil |
| Italian italiano | 4-aminobifenile |
| Latvian latviešu | bifenil-4-ilamīns ksenilamīns4-aminobifenils |
| Lithuanian lietuvių | bifenil-4-ilaminas ksenilaminas4-aminobifenilas |
| Hungarian magyar | bifenil-4-ilamin xenilamin4-aminobifenil |
| Maltese Malti | bifenil-4-ilammina ksenilammina4-amminobifenil |
| Dutch Nederlands | bifenyl-4-ylamine xenylamine4-aminobifenyl |
| Polish polski | bifenylo-4-amina 4-aminobifenyl |
| Portuguese português | bifenil-4-ilamina xenilamina4-aminobifenilo |
| Romanian română | bifenil-4-ilamină xenilamină4-aminobifenil |
| Slovak slovenčina | bifenyl-4-amín xenylamín4-aminobifenyl |
| Slovenian slovenščina | bifenil-4-ilamin ksenilamin4-aminobifenil |
| Finnish suomi | 4-aminobifenyyli ksenyyliamiinibifenyl-4-yyliamiini |
| Swedish svenska | bifenyl-4-ylamin xenylamin4-aminobifenyl |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Biphenyl-4-ylamine GHS label elements
Everything CLP Annex VI fixes for Biphenyl-4-ylamine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Biphenyl-4-ylamine
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Biphenyl-4-ylamine in the GHS label constructor →
07 · Health hazards
Biphenyl-4-ylamine health hazards and exposure limits
Biphenyl-4-ylamine hazard summary
Limited exposure to 4-aminobiphenyl occurs since it is no longer produced commercially. Acute (short- term) inhalation exposure to 4-aminobiphenyl produces headaches, lethargy, cyanosis, urinary burning, and hematuria (the presence of blood in urine) in humans. 4-Aminobiphenyl is a known human bladder carcinogen and animal studies have reported an increase in bladder and liver tumors from oral exposure. EPA has not classified 4-aminobiphenyl for potential carcinogenicity; however, the International Agency for Research on Cancer (IARC) has classified 4-aminobiphenyl as a Group 1 carcinogen, the agent is carcinogenic to humans.
Source: EPA Hazardous Air Pollutants
Biphenyl-4-ylamine carcinogenicity classification
Sufficient evidence of carcinogenicity in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 1: The agent is carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
4-Aminobiphenyl: known to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Biphenyl-4-ylamine occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | Ca | Occupational Safety and Health Administration (OSHA) |
| PEL | [1910.1011] See Appendix B | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | Ca See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | Ca [N.D.] | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Biphenyl-4-ylamine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Biphenyl-4-ylamine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 302 °C (575.6 °F) | HSDB | |
| 302.22 °C (576 °F) | NIOSH | ||
| 302.22 °C (576 °F) | at 760 mmHg | CAMEO |
Biphenyl-4-ylamine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 51 °C (123.8 °F) | HSDB | |
| 52.78 °C (127 °F) | NIOSH |
Biphenyl-4-ylamine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.16 g/cm³ | NIOSH | |
| 1.16 g/cm³ | at 20 °C | HSDB |
Biphenyl-4-ylamine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in cold water; readily soluble in hot water | HSDB | |
| Soluble in ethanol, ether, acetone, chloroform | HSDB | ||
| Soluble in dichloromethane, DMSO, methanol | HSDB |
Biphenyl-4-ylamine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.00032 mmHg | at 25 °C | HSDB |
| 0.0005775 mmHg | at 25 °C | ICSC | |
| 1 mmHg | at 108.33 °C | HSDB |
Biphenyl-4-ylamine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 113 °C (235.4 °F) | HSDB | |
| 153 °C (307.4 °F) | closed cup | HSDB |
Biphenyl-4-ylamine autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 450 °C (842 °F) | HSDB |
Biphenyl-4-ylamine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Combustible Solid, but must be preheated before ignition possible. | NIOSH |
Biphenyl-4-ylamine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 5.8 (air = 1) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Biphenyl-4-ylamine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Biphenyl-4-ylamine fire potential
Slight to moderate when exposed to heat, flames, (sparks) or powerful oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Biphenyl-4-ylamine storage and handling
Biphenyl-4-ylamine safe storage
Separated from strong oxidants and acids. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Biphenyl-4-ylamine storage conditions
Keep container tightly closed in a dry and well-ventilated place.
Source: Hazardous Substances Data Bank (HSDB)
Biphenyl-4-ylamine incompatible materials
Incompatible materials: Strong oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
Biphenyl-4-ylamine reactivity
4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. (NTP, 1992). May react with strong oxidizing agents.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Biphenyl-4-ylamine in the storage compatibility matrix →
11 · Questions
Biphenyl-4-ylamine — frequently asked questions
What is the CAS number of Biphenyl-4-ylamine?
The CAS number of Biphenyl-4-ylamine is 92-67-1. Its EC number is 202-177-1.
What is the chemical formula of Biphenyl-4-ylamine?
The molecular formula of Biphenyl-4-ylamine is C12H11N and its molecular weight is 169.22 g/mol.
What does a Biphenyl-4-ylamine label have to show?
Under CLP Annex VI the label for Biphenyl-4-ylamine carries the pictograms Health hazard and Exclamation mark and the signal word is Danger.
Is Biphenyl-4-ylamine flammable?
CLP Annex VI assigns Biphenyl-4-ylamine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 113 °C (235.4 °F) (HSDB).
Is Biphenyl-4-ylamine a carcinogen?
Yes. CLP Annex VI classifies Biphenyl-4-ylamine as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 1: carcinogenic to humans.
What is the exposure limit for Biphenyl-4-ylamine?
The US occupational exposure limit reported for Biphenyl-4-ylamine is Ca (Occupational Safety and Health Administration (OSHA)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Biphenyl-4-ylamine?
The boiling point reported for Biphenyl-4-ylamine is 302 °C (575.6 °F) (HSDB).
What is the melting point of Biphenyl-4-ylamine?
The melting point reported for Biphenyl-4-ylamine is 51 °C (123.8 °F) (HSDB).
How should Biphenyl-4-ylamine be stored?
Keep container tightly closed in a dry and well-ventilated place. (Hazardous Substances Data Bank (HSDB))
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