Substance profile
Captafol
Captafol is a white, solid with a slight, characteristic pungent odor.
01 · Identification
What Captafol is
Captafol is a white, solid with a slight, characteristic pungent odor. Its molecular formula is C10H9Cl4NO2S and its molecular weight is 349.1 g/mol. It melts at 161 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
Captafol identifiers and molecular data
Captafol CAS number and EC number
Captafol molecular formula and molecular weight
Other names for Captafol
- captafol (ISO)
- 1,2,3,6-tetrahydro-N-(1,1,2,2-tetrachloroethylthio)phthalimide
03 · GHS classification
Captafol hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Captafol pictograms and signal word
Captafol hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Captafol hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Captafol. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Captafol
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Captafol issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Captafol precautionary statements
CLP Annex VI assigns 10 precautionary statements to Captafol. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Captafol name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | каптафол (ISO) N -(1,1,2,2-тетрахлороетилтио)-1,2,3,6-тетрахидрофталимид |
| Spanish español | Captafol (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2-tetracloroetiltio)ftalimida |
| Czech čeština | kaptafol (ISO) N -[(1,1,2,2-tetrachlorethyl)sulfanyl]-1,2,3,6-tetrahydroftalimid |
| Danish dansk | captafol (ISO) 1,2,3,6-tetrahydro- N -(1,1,2,2- tetrachlorethylthio)phthalimid |
| German Deutsch | Captafol (ISO) 1,2,3,6-Tetrahydro- N -(1,1,2,2-tetrachlorethylthio)phthalimid |
| Estonian eesti | kaptafool (ISO) 1,2,3,6-tetrahüdro- N -(1,1,2,2-tetrakloroetüültio)ftaalimiid |
| Greek ελληνικά | captafol (καπταφόλη) (ISO) 1,2,3,6-τετραϋδρο- N -(1,1,2,2-τετραχλωροαιθυλοθειο)φθαλιμίδιο |
| English English | captafol (ISO) 1,2,3,6-tetrahydro- N -(1,1,2,2- tetrachloroethylthio)phthalimide |
| French français | captafol (ISO) 1,2,3,6-tétrahydro- N -(1,1,2,2-tétrachloroéthylthio)phthalimide |
| Croatian hrvatski | kaptafol (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2-tetrakloretiltio)ftalimid |
| Italian italiano | captafol (ISO) N -(1,1,2,2-tetracloroetiltio)ciclo-es-4-ene-1,2-dicarbossimide |
| Latvian latviešu | kaptafols (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2-tetrahloretiltio)ftalimīds |
| Lithuanian lietuvių | kaptafolas (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2-tetrachloretiltio)ftalimidas |
| Hungarian magyar | kaptafol (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2- tetraklóretiltio)ftálimid |
| Maltese Malti | kaptafol (ISO) 1,2,3,6-tetraidro- N -(1,1,2,2-tetrakloroetiltijo)ftalimmid |
| Dutch Nederlands | captafol (ISO) 1,2,3,6-tetrahydro- N -(1,1,2,2-tetrachloorethylthio)ftaalimide |
| Polish polski | kaptafol (ISO) N -(1,1,2,2-tetrachloroetylosulfanylo)cykloheks-4-eno-1,2-dikarboksyimidN -(1,1,2,2-tetrachloroetylosulfanylo)-1,2,3,6-tetrahydroftalimid |
| Portuguese português | captafol (ISO) 1,2,3,6-tetra-hidro- N -(1,1,2,2-tetracloroetiltio)ftalimida |
| Romanian română | captafol (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2-tetracloroetiltio) ftalimidă |
| Slovak slovenčina | kaptafol (ISO) N -(1,1,2,2-tetrachlóretylsulfanyl)-1,2,3,6-tetrahydroftalimid |
| Slovenian slovenščina | kaptafol (ISO) 1,2,3,6-tetrahidro- N -(1,1,2,2-tetrakloroetiltio)ftalimid |
| Finnish suomi | kaptafoli (ISO) 1,2,3,6-tetrahydro- N -(1,1,2,2-tetrakloorietyylitio)ftaali-imidi |
| Swedish svenska | kaptafol (ISO) 1,2,3,6-tetrahydro- N -(1,1,2,2-tetrakloretyltio)ftalimid |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Captafol GHS label elements
Everything CLP Annex VI fixes for Captafol, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Captafol
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
- If skin irritation or rash occurs:
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Captafol in the GHS label constructor →
07 · Health hazards
Captafol health hazards and exposure limits
Captafol carcinogenicity classification
Evaluation: No data were available from studies in humans. There is sufficient evidence in experimental animals for the carcinogenicity of captafol. In making the overall evaluation, the working group took into consideration the following supporting evidence: Captafol is active in a wide range of tests for genetic and related effects, including the generally insensitive in vivo assay for dominant lethal mutation. Overall evaluation: Captafol is probably carcinogenic to humans (2A).
Source: Hazardous Substances Data Bank (HSDB)
Cancer Classification: Group 2B Probable Human carcinogen
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Captafol occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none See Appendix G | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | Ca TWA 0.1 mg/m3 [skin] See Appendix A | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | NIOSH considers captafol to be a potential occupational carcinogen. | Hazardous Substances Data Bank (HSDB) |
| IDLH | Ca [N.D.] | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Captafol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Captafol boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | Decomposes | decomposes | NIOSH |
| Decomposes (NIOSH, 2024) | decomposes | CAMEO | |
| decomposes | decomposes | OSHA |
Captafol melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 160.5 °C (320.9 °F) | range, midpoint shown | HSDB |
| 160.56 °C (321 °F) | decomposes | NIOSH |
Captafol density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00 | at 20 °C | ICSC |
Captafol solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | 0.0001% | NIOSH | |
| In water, 1.4 mg/l @ 20 °C | at 20 °C | HSDB |
Captafol vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000008 mmHg | NIOSH | |
| 8.27e-9 mmHg | at 20 °C | HSDB |
Captafol lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Noncombustible Solid, but may be dissolved in flammable liquids. | NIOSH |
Captafol vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 12 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Source notes
Further notes on Captafol
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Solubility
Slightly soluble in most organic solvents; solubility (g/kg): isopropanol 13; benzene 25; toluene 17; xylene 100; acetone 43; methyl ethyl ketone 44; dimethyl sulfoxide 170
Source: HSDB
10 · Handling and storage
Captafol storage and handling
Captafol safe storage
Provision to contain effluent from fire extinguishing. Separated from strong bases and food and feedstuffs. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Captafol storage conditions
Provision to contain effluent from fire extinguishing. Separated from strong bases, food and feedstuffs.
Source: Hazardous Substances Data Bank (HSDB)
Captafol incompatible materials
Incompatible with highly alkaline materials.
Source: Hazardous Substances Data Bank (HSDB)
Captafol reactivity
CAPTAFOL is non-flammable but, on heating, may decompose to generate toxic fumes, such as sulfur oxides, hydrogen sulfide, hydrochloric acid, and phosgene. Stable at room temperature when dry but readily hydrolysed, especially in an alkaline environment. Captafol and mixtures containing high concentrations of captafol may react violently with alkali. Incompatible with acids, acid chlorides, acid anhydrides, and strong oxidizing agents. Sulfhydryl compounds such as glutathione and cysteine cause a rapid chemical decomposition.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Captafol in the storage compatibility matrix →
11 · Questions
Captafol — frequently asked questions
What is the CAS number of Captafol?
The CAS number of Captafol is 2425-06-1. Its EC number is 219-363-3.
What is the chemical formula of Captafol?
The molecular formula of Captafol is C10H9Cl4NO2S and its molecular weight is 349.1 g/mol.
What does a Captafol label have to show?
Under CLP Annex VI the label for Captafol carries the pictograms Health hazard and Environment and the signal word is Danger.
Is Captafol flammable?
CLP Annex VI assigns Captafol no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Captafol a carcinogen?
Yes. CLP Annex VI classifies Captafol as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2A: probably carcinogenic to humans.
What is the exposure limit for Captafol?
The US occupational exposure limit reported for Captafol is none See Appendix G (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Captafol?
The boiling point reported for Captafol is Decomposes, decomposes (NIOSH).
What is the melting point of Captafol?
The melting point reported for Captafol is 160.5 °C (320.9 °F), range, midpoint shown (HSDB).
How should Captafol be stored?
Provision to contain effluent from fire extinguishing. Separated from strong bases, food and feedstuffs. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Captafol
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