Substance profile
Difenacoum
Difenacoum is colorless crystals and is odorless.
01 · Identification
What Difenacoum is
Difenacoum is colorless crystals and is odorless. Its molecular formula is C31H24O3 and its molecular weight is 444.5 g/mol. It boils at 290 °C, melts at 216 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Difenacoum identifiers and molecular data
Difenacoum CAS number and EC number
Difenacoum molecular formula and molecular weight
Other names for Difenacoum
- difenacoum (ISO)
- 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin
03 · GHS classification
Difenacoum hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Difenacoum pictograms and signal word
Difenacoum hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 1 or 2 | H300 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 1 or 2 | H310 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 1 | H372 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Difenacoum hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H360D | May damage the unborn child. |
| H330 | Fatal if inhaled. |
| H310 | Fatal in contact with skin. |
| H300 | Fatal if swallowed. |
| H372 | Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Difenacoum. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Difenacoum
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Difenacoum issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Difenacoum precautionary statements
CLP Annex VI assigns 14 precautionary statements to Difenacoum. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Difenacoum name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | дифенакум (ISO) 3-(3-бифенил-4-ил-1,2,3,4-тетрахидро-1-нафтил)-4-хидроксикумарин |
| Spanish español | difenácum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroxicumarina |
| Czech čeština | difenakum (ISO) 3-[3-(bifenyl-4-yl)-1,2,3,4-tetrahydro-1-naftyl]-4-hydroxy-2 H -chromen-2-on |
| Danish dansk | difenacoum (ISO) 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin |
| German Deutsch | Difenacoum (ISO) 3-(3-Biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycumarin |
| Estonian eesti | difenaakum (ISO) 3-(3-bifenüül-4-üül-1,2,3,4-tetrahüdro-1-naftüül)-4-hüdroksükumariin |
| Greek ελληνικά | διφενακούμη (ISO) 3-(3-διφαινυλ-4-υλ-1,2,3,4-τετραϋδρο-1-ναφθυλ)-4-υδροξυκουμαρίνη |
| English English | difenacoum (ISO) 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin |
| French français | difénacoum (ISO) 3-(3-biphényl-4-yl-1,2,3,4-tétrahydro-1-naphtyl)-4-hydroxycoumarine |
| Croatian hrvatski | difenakum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroksikumarin |
| Italian italiano | difenacum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetraidro-1-naftil)-4-idrossicoumarina |
| Latvian latviešu | difenakums ( ISO ) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroksikumarīns |
| Lithuanian lietuvių | difenakumas (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroksikumarinas |
| Hungarian magyar | difenakum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroxikumarin |
| Maltese Malti | difenakum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetraidro-1-naftil)-4-idrossikumarin |
| Dutch Nederlands | difenacum (ISO) 3-(3-bifenyl-4-yl-1,2,3,4-tetrahydro-1-naftyl)-4-hydroxycumarine |
| Polish polski | difenakum (ISO) 3-[3-(bifenyl-4-ylo)-1,2,3,4-tetrahydro-1-naftylo]-4-hydroksykumaryna |
| Portuguese português | difenacume (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetra-hidro-1-naftil)-4-hidroxicumarina |
| Romanian română | difenacum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroxicumarină |
| Slovak slovenčina | 3-[3-(bifenyl-4-yl)-1,2,3,4-tetrahydro-1-naftyl]-4-hydroxy-2H-chromén-2-ón difenakum |
| Slovenian slovenščina | difenakum (ISO) 3-(3-bifenil-4-il-1,2,3,4-tetrahidro-1-naftil)-4-hidroksikumarin |
| Finnish suomi | difenakumi (ISO) 3-(3-bifenyl-4-yyli-1,2,3,4-tetrahydro-1-naftyyli)-4-hydroksikumariini |
| Swedish svenska | difenakum (ISO) 3-(3-bifenyl-4-yl-1,2,3,4-tetrahydro-1-naftyl)-4-hydroxikumarin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Difenacoum GHS label elements
Everything CLP Annex VI fixes for Difenacoum, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Difenacoum
- May damage the unborn child.
- Fatal if inhaled.
- Fatal in contact with skin.
- Fatal if swallowed.
- Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention if you feel unwell.
- Rinse mouth.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Difenacoum in the GHS label constructor →
07 · Health hazards
Difenacoum health hazards and exposure limits
Difenacoum hazard summary
A vitamin K antagonist--causes clotting factor disruption and bleeding tendency; Two patients had abnormal vitamin K1 metabolism for more than 18 months after exposure, although prothrombin time and vitamin K-dependent clotting factors were normal; No unscheduled DNA synthesis induced in rat hepatocytes; [HSDB] See Warfarin.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Difenacoum properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Difenacoum boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 290 °C (554 °F) | decomposes, decomposes before boiling | HSDB |
Difenacoum melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 216 °C (420.8 °F) | range, midpoint shown | HSDB |
Difenacoum density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.27 g/cm³ | at 21.5 °C | HSDB |
Difenacoum solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly soluble in alcohols; soluble in acetone, chloroform, and other chlorinated solvents. | HSDB | |
| In water at 20 °C, 84 mg/L (pH 9.3); 2.5 mg/L (pH 7.3); 0.031 mg/L (pH 5.2) | at 20 °C | HSDB | |
| In water at 20 °C, 0.0025 mg/L at pH 4.0; 0.483 mg/L at pH 6.5; 3.72 mg/L at pH 8.9 | at 20 °C | HSDB |
Difenacoum vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 5e-11 mmHg | at 25 °C | HSDB |
| 0.0000012 mmHg | at 45 °C | HSDB | |
| 0.0000012 mmHg | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Difenacoum fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Difenacoum fire potential
Not flammable or combustible.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Difenacoum storage and handling
Difenacoum storage conditions
Keep away from food or water supplies, children, domestic animals, and wildlife. Keep container closed for freshness; do not re-use empty container.
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Difenacoum in the storage compatibility matrix →
11 · Questions
Difenacoum — frequently asked questions
What is the CAS number of Difenacoum?
The CAS number of Difenacoum is 56073-07-5. Its EC number is 259-978-4.
What is the chemical formula of Difenacoum?
The molecular formula of Difenacoum is C31H24O3 and its molecular weight is 444.5 g/mol.
What does a Difenacoum label have to show?
Under CLP Annex VI the label for Difenacoum carries the pictograms Health hazard, Skull and crossbones and Environment and the signal word is Danger.
Is Difenacoum flammable?
CLP Annex VI assigns Difenacoum no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Difenacoum a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Difenacoum. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Difenacoum?
The boiling point reported for Difenacoum is 290 °C (554 °F), decomposes, decomposes before boiling (HSDB).
What is the melting point of Difenacoum?
The melting point reported for Difenacoum is 216 °C (420.8 °F), range, midpoint shown (HSDB).
How should Difenacoum be stored?
Keep away from food or water supplies, children, domestic animals, and wildlife. Keep container closed for freshness; do not re-use empty container. (Hazardous Substances Data Bank (HSDB))
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