Substance profile
Ethylenediamine
Ethylenediamine is a water-white liquid with an ammonia-like odor.
01 · Identification
What Ethylenediamine is
Ethylenediamine is a water-white liquid with an ammonia-like odor. Its molecular formula is C2H8N2 and its molecular weight is 60.1 g/mol. It boils at 116 °C, melts at 8.5 °C.
Under the GHS it carries the signal word Danger. It is classed as corrosives.
02 · Identifiers
Ethylenediamine identifiers and molecular data
Ethylenediamine CAS number and EC number
Ethylenediamine molecular formula and molecular weight
Other names for Ethylenediamine
- 1,2-diaminoethane
03 · GHS classification
Ethylenediamine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Ethylenediamine pictograms and signal word
Ethylenediamine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Flammable liquids GHS chapter 2.6 | Category 3 | H226 | GHS02 |
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 4 | H312 | GHS07 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 1A or 1B or 1C | H314 | GHS05 |
| Respiratory sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H334 | GHS08 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Ethylenediamine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H226 | Flammable liquid and vapour. |
| H312 | Harmful in contact with skin. |
| H302 | Harmful if swallowed. |
| H314 | Causes severe skin burns and eye damage. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H317 | May cause an allergic skin reaction. |
This page lists only the codes assigned to Ethylenediamine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Ethylenediamine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Ethylenediamine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Ethylenediamine precautionary statements
CLP Annex VI assigns 19 precautionary statements to Ethylenediamine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Ethylenediamine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | етилендиамин 1,2-диаминоетан |
| Spanish español | Etilendiamina 1,2-diaminoetano |
| Czech čeština | ethylendiamin ethan-1,2-diamin |
| Danish dansk | ethylendiamin 1,2-diaminoethan |
| German Deutsch | Ethylendiamin 1,2-Diaminoethan |
| Estonian eesti | etüleendiamiin 1,2-diaminoetaan |
| Greek ελληνικά | αιθυλενοδιαμίνη 1,2-διαμινοαιθάνιο |
| English English | ethylenediamine 1,2-diaminoethane |
| French français | éthylènediamine 1,2-diaminoéthane |
| Croatian hrvatski | etilendiamin 1,2-diaminoetan |
| Italian italiano | etilendiamina 1,2-diaminoetano |
| Latvian latviešu | etilēndiamīns 1,2-diaminoetāns |
| Lithuanian lietuvių | etilendiaminas 1,2-diaminoetanas |
| Hungarian magyar | etiléndiamin 1,2-diaminoetán |
| Maltese Malti | etilendiammina 1,2-diamminoetan |
| Dutch Nederlands | ethyleendiamine 1,2-diaminoëthaan |
| Polish polski | etylenodiamina etano-1,2-diamina |
| Portuguese português | etilenodiamina 1,2-diaminoetano |
| Romanian română | etilendiamină 1,2-diaminoetan |
| Slovak slovenčina | etyléndiamín etán-1,2-diamín |
| Slovenian slovenščina | etilendiamin 1,2-diaminoetan |
| Finnish suomi | etyleenidiamiini 1,2-diaminoetaani |
| Swedish svenska | etylendiamin 1,2-diaminoetan |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Ethylenediamine GHS label elements
Everything CLP Annex VI fixes for Ethylenediamine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Ethylenediamine
- Flammable liquid and vapour.
- Harmful in contact with skin.
- Harmful if swallowed.
- Causes severe skin burns and eye damage.
- May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- May cause an allergic skin reaction.
- Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Keep container tightly closed.
- Use explosion-proof [electrical/ventilating/lighting/…] equipment.
- Use only non-sparking tools.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Contaminated work clothing should not be allowed out of the workplace.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- Immediately call a POISON CENTER/doctor/…
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- Do NOT induce vomiting.
- If skin irritation or rash occurs:
- Wash with plenty of water/…
- Store in a well-ventilated place.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Ethylenediamine in the GHS label constructor →
07 · Health hazards
Ethylenediamine health hazards and exposure limits
Ethylenediamine hazard summary
Liquid causes second degree burns after contact for a few minutes; [CHRIS] Corrosive to skin; [Quick CPC] Ethylenediamine is used in topical creams and suppositories, e.g., nystatin cream and aminophylline suppositories. Allergic contact dermatitis has been reported in a pharmacist and in healthcare workers. [Marks, p. 85-7] Allergic contact dermatitis in healthcare workers reported after exposure to intravenous aminophylline preparations containing ethylenediamine; [Kanerva, p. 1520] Occupational asthma reported in shellac handler and photographer; [Malo] Can cause pulmonary edema after an acute inhalation exposure; [ICSC] Danger of skin and airway sensitization; [MAK] Humans complain of nasal irritation after inhaling concentrations of 200 ppm for 5-10 minutes. [CAMEO] A lachrymator; [CHEMINFO]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Ethylenediamine carcinogenicity classification
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity
Source: Hazardous Substances Data Bank (HSDB)
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on no human data and inadequate animal data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA:Inadequate.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
Ethylenediamine occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | 10.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| PEL | 10 ppm (25 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| PEL | TWA 10 ppm (25 mg/m3) | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | 10 ppm (25 mg/m³) | Occupational Safety and Health Administration (OSHA) |
| REL | TWA 10 ppm (25 mg/m3) | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | 1000 ppm (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | 1000.0 [ppm] | Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| IDLH | 1000 ppm | Hazardous Substances Data Bank (HSDB) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
Ethylenediamine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Ethylenediamine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 116.11 °C (241 °F) | NIOSH | |
| 116.11 °C (241 °F) | at 760 mmHg | CAMEO | |
| 117 °C (242.6 °F) | ICSC |
Ethylenediamine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 8.5 °C (47.3 °F) | HSDB | |
| 8.33 °C (47 °F) | NIOSH | ||
| 7.78 °C (46 °F) | CAMEO |
Ethylenediamine density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 0.91 g/cm³ | NIOSH | |
| 0.898 g/cm³ | at 25 °C | HSDB |
Ethylenediamine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Sol in benzene unless insufficiently dried; slightly sol in ether | HSDB | |
| SOL IN ALL PROPORTIONS IN ETHYL ALCOHOL; VERY SOL IN WATER | HSDB | ||
| Crystals; sublimes without melting; freely sol in water; practically insol in alc | sublimes, Dihydrochloride | HSDB |
Ethylenediamine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 11 mmHg | NIOSH | |
| 10.7 mmHg | at 20 °C | CAMEO | |
| 12.1 mmHg | at 25 °C | HSDB |
Ethylenediamine flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 40 °C (104 °F) | ANHYDROUS 76% | HSDB |
| 43.33 °C (110 °F) | HSDB | ||
| 33.9 °C (93 °F) | open cup | HSDB |
Ethylenediamine autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 385 °C (725 °F) | ANHYDROUS 76% | HSDB |
| 379.44 °C (715 °F) | CAMEO | ||
| 385 °C (725 °F) | ICSC |
Ethylenediamine lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | 4.2 % by volume | CAMEO | |
| 2.5 % by volume | ICSC |
Ethylenediamine upper explosive limit (UEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Upper explosive limit (UEL) | 14.4 % by volume | CAMEO | |
| 16.6 % by volume | ICSC |
Ethylenediamine vapor density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor density | 2.07 (air = 1) | HSDB | |
| 2.1 (air = 1) | ICSC |
Ethylenediamine odor threshold
| Property | Value | Conditions | Source |
|---|---|---|---|
| Odor threshold | Odor recognition in air= 3.40 ppm (purity not specified) | HSDB | |
| Odor low= 2.50 mg/cu m; Odor high= 28.0 mg/cu m | HSDB |
Ethylenediamine critical temperature and pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Critical temperature and pressure | 320 °C (608 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Ethylenediamine fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Ethylenediamine fire potential
FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME OR OXIDIZERS.
Source: Hazardous Substances Data Bank (HSDB)
Odor
Water odor threshold: 16000 mg/l @ pKa of 10.0. Air odor threshold: 1.0 ppm. Odor Safety Class: C. C= Odor safety factor from 1-26. Less than 50% of distracted persons perceive warning of TLV.
Source: HSDB
10 · Handling and storage
Ethylenediamine storage and handling
Ethylenediamine safe storage
Fireproof. Separated from strong oxidants, acids, chlorinated organic compounds and food and feedstuffs. Cool. Well closed. Store only in original container.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Ethylenediamine storage conditions
Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location.
Source: Hazardous Substances Data Bank (HSDB)
Ethylenediamine incompatible materials
Carbon disulfide reacts violently with ... ethylenediamine.
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Ethylenediamine in the storage compatibility matrix →
11 · Transport
Ethylenediamine UN number and transport classification
Transport classification is a separate system from the GHS classification above. It decides how a package is marked and how a load may be carried; it does not follow from the workplace label, and the workplace label does not follow from it. The entries below are linked by CAS number, never by name.
Ethylenediamine under UN 1604 — shipping name, class and packing group
Europe · ADR 2025, Table A
| Proper shipping name (3.1.2) | Class | Classification code | PG | Labels (column 5) |
|---|---|---|---|---|
| ETHYLENEDIAMINE | 8 | CF1 | II | |
Source: ADR 2025, Table A of Chapter 3.2 · ECE/TRANS/352 Vol. I (UNECE). Class 8 is “Corrosive substances” (ADR 2.1.1.1).
United States · 49 CFR 172.101 Hazardous Materials Table
| Proper shipping name (column 2) | Class or division | PG | Labels (column 6) |
|---|---|---|---|
| Ethylenediamine | 8 | II | |
Source: 49 CFR 172.101 Hazardous Materials Table · eCFR, revision 2026-08-03. Class 8 is “Corrosive material” (49 CFR 173.2).
12 · Questions
Ethylenediamine — frequently asked questions
What is the CAS number of Ethylenediamine?
The CAS number of Ethylenediamine is 107-15-3. Its EC number is 203-468-6.
What is the chemical formula of Ethylenediamine?
The molecular formula of Ethylenediamine is C2H8N2 and its molecular weight is 60.1 g/mol.
What does a Ethylenediamine label have to show?
Under CLP Annex VI the label for Ethylenediamine carries the pictograms Flame, Health hazard, Corrosion and Exclamation mark and the signal word is Danger.
Is Ethylenediamine flammable?
Yes. CLP Annex VI assigns Ethylenediamine H226 — flammable liquid and vapour. The flash point reported for it is 40 °C (104 °F), ANHYDROUS 76% (HSDB).
Is Ethylenediamine a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Ethylenediamine. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the exposure limit for Ethylenediamine?
The US occupational exposure limit reported for Ethylenediamine is 10.0 [ppm] (Haz-Map, Information on Hazardous Chemicals and Occupational Diseases). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of Ethylenediamine?
The boiling point reported for Ethylenediamine is 116.11 °C (241 °F) (NIOSH).
What is the melting point of Ethylenediamine?
The melting point reported for Ethylenediamine is 8.5 °C (47.3 °F) (HSDB).
How should Ethylenediamine be stored?
CLP Annex VI assigns Ethylenediamine the storage statement P403. Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location. (Hazardous Substances Data Bank (HSDB))
Nearby
Substances next to Ethylenediamine
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