Substance profile
Hydrazobenzene
Hydrazobenzene is a tablets from alcohol and ether.
01 · Identification
What Hydrazobenzene is
Hydrazobenzene is a tablets from alcohol and ether. Its molecular formula is C12H12N2 and its molecular weight is 184.24 g/mol. It boils at 293 °C, melts at 131 °C.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
Hydrazobenzene identifiers and molecular data
Hydrazobenzene CAS number and EC number
Hydrazobenzene molecular formula and molecular weight
Other names for Hydrazobenzene
- 1,2-diphenylhydrazine
03 · GHS classification
Hydrazobenzene hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Hydrazobenzene pictograms and signal word
Hydrazobenzene hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Hydrazobenzene hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Hydrazobenzene. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Hydrazobenzene
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Hydrazobenzene issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Hydrazobenzene precautionary statements
CLP Annex VI assigns 11 precautionary statements to Hydrazobenzene. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Hydrazobenzene name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | хидразобензен 1,2-дифенилхидразин |
| Spanish español | Hidrazobenceno 1,2-difenilhidrazina |
| Czech čeština | hydrazobenzen 1,2-difenylhydrazin |
| Danish dansk | hydrazobenzen 1,2-diphenylhydrazin |
| German Deutsch | Hydrazobenzol 1,2-Diphenylhydrazin |
| Estonian eesti | hüdrasobenseen 1,2-difenüülhüdrasiin |
| Greek ελληνικά | υδραζωβενζόλιο 1,2-διφαινυλυδραζίνη |
| English English | hydrazobenzene 1,2-diphenylhydrazine |
| French français | hydrazobenzène 1,2-diphénylhydrazine |
| Croatian hrvatski | hidrazobenzen 1,2-difenil-hidrazin |
| Italian italiano | idrazobenzene 1,2-difenilidrazina |
| Latvian latviešu | hidrazobenzols 1,2-difenilhidrazīns |
| Lithuanian lietuvių | hidrazobenzenas 1,2-difenilhidrazinas |
| Hungarian magyar | hidrazobenzol 1,2-difenilhidrazin |
| Maltese Malti | idrażobenżen 1,2-difenilidrażina |
| Dutch Nederlands | hydrazobenzeen 1,2-difenylhydrazine |
| Polish polski | hydrazobenzen 1,2-difenylohydrazyna |
| Portuguese português | hidrazobenzeno 1,2-difenil-hidrazina |
| Romanian română | hidrazobenzen 1,2-difenilhidrazină |
| Slovak slovenčina | hydrazobenzén 1,2-difenylhydrazín |
| Slovenian slovenščina | hidrazobenzen 1,2-difenilhidrazin |
| Finnish suomi | hydratsobentseeni 1,2-difenyylihydratsiini |
| Swedish svenska | hydrazobensen 1,2-difenylhydrazin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Hydrazobenzene GHS label elements
Everything CLP Annex VI fixes for Hydrazobenzene, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Hydrazobenzene
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Harmful if swallowed.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Hydrazobenzene in the GHS label constructor →
07 · Health hazards
Hydrazobenzene health hazards and exposure limits
Hydrazobenzene hazard summary
1,2-Diphenylhydrazine is a white solid. There is no information on what it smells like or whether it will burn. It does not dissolve easily in water, but when placed in water, it rapidly breaks down into other chemicals. These include the toxic chemicals benzidine and azobenzene. It does not evaporate easily but may be released to air when attached to dust particles. 1,2-Diphenylhydrazine is a man-made chemical that was used in the past to make benzidine which was used to make various fabric dyes. Benzidine dyes are no longer used in the United States, but may still be used in other countries. The only current use of 1,2-diphenylhydrazine in the United States is in the production of medicines to treat inflammation and a type of arthritis.
Source: Agency for Toxic Substances and Disease Registry (ATSDR)
Hydrazobenzene carcinogenicity classification
Under the conditions of this bioassay, hydrazobenzene was carcinogenic to Fischer 344 rats of both sexes, causing increased incidences of hepatocellular carcinoma and Zymbal's gland squamous-cell neoplasms in male rats, neoplastic nodules of the liver in female rats, and mammary adenocarcinomas in female rats. Hydrazobenzene was also carcinogenic to female B6C3F1 mice, causing an increased incidence of hepatocellular carcinomas. The compound was not carcinogenic to male B6C3F1 mice.
Source: US National Toxicology Program · TR-092: Bioassay of Hydrazobenzene for Possible Carcinogenicity (CASRN 122-66-7) (1978 )
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Positive results of studies in both rats and mice form the basis for this classification. Two apparently negative studies lack information on compound purity, experimental design, and statistical treatment. HUMAN CARCINOGENICITY DATA: None.
Source: Hazardous Substances Data Bank (HSDB)
Hydrazobenzene: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Hydrazobenzene properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Hydrazobenzene boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 293 °C (559.4 °F) | at 760 mmHg | HSDB |
| Decomposes (NTP, 1992) | decomposes | CAMEO |
Hydrazobenzene melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 131.11 °C (268 °F) | CAMEO | |
| 131 °C (267.8 °F) | DOE PAC | ||
| 131 °C (267.8 °F) | decomposes | HSDB |
Hydrazobenzene density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.16 g/cm³ | ICSC | |
| 1.158 g/cm³ | at 16.11 °C | CAMEO | |
| 1.158 g/cm³ | at 16 °C | HSDB |
Hydrazobenzene solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Slightly sol in benzene, deuterated dimethyl sulfoxide; insol in acetic acid; very soluble in ethanol | HSDB | |
| Solubility in water, g/100ml at 20 °C: | at 20 °C | ICSC | |
| In water, 221 mg/L at 25 °C | at 25 °C | HSDB |
Hydrazobenzene vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.00044 mmHg | at 25 °C | HSDB |
| 0.00044 mmHg | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
Hydrazobenzene storage and handling
Hydrazobenzene safe storage
Separated from food and feedstuffs. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Hydrazobenzene storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
Hydrazobenzene reactivity
Toxic gases may be formed by mixing DIPHENYLHYDRAZINE with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Hydrazobenzene in the storage compatibility matrix →
10 · Questions
Hydrazobenzene — frequently asked questions
What is the CAS number of Hydrazobenzene?
The CAS number of Hydrazobenzene is 122-66-7. Its EC number is 204-563-5.
What is the chemical formula of Hydrazobenzene?
The molecular formula of Hydrazobenzene is C12H12N2 and its molecular weight is 184.24 g/mol.
What does a Hydrazobenzene label have to show?
Under CLP Annex VI the label for Hydrazobenzene carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Danger.
Is Hydrazobenzene flammable?
CLP Annex VI assigns Hydrazobenzene no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Hydrazobenzene a carcinogen?
Yes. CLP Annex VI classifies Hydrazobenzene as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of Hydrazobenzene?
The boiling point reported for Hydrazobenzene is 293 °C (559.4 °F), at 760 mmHg (HSDB).
What is the melting point of Hydrazobenzene?
The melting point reported for Hydrazobenzene is 131.11 °C (268 °F) (CAMEO).
How should Hydrazobenzene be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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