Substance profile
Methylisothiazolinone
Methylisothiazolinone is colorless prisms.
01 · Identification
What Methylisothiazolinone is
Methylisothiazolinone is colorless prisms. Its molecular formula is C4H5NOS and its molecular weight is 115.16 g/mol. It melts at 50.5 °C.
Under the GHS it carries the signal word Danger.
02 · Identifiers
Methylisothiazolinone identifiers and molecular data
Methylisothiazolinone CAS number and EC number
Methylisothiazolinone molecular formula and molecular weight
Other names for Methylisothiazolinone
- 2-methylisothiazol-3(2H)-one
03 · GHS classification
Methylisothiazolinone hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Methylisothiazolinone pictograms and signal word
Methylisothiazolinone hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 3 | H301 | GHS06 |
| Acute toxicity - dermal GHS chapter 3.1 | Category 3 | H311 | GHS06 |
| Acute toxicity - inhalation GHS chapter 3.1 | Category 1 or 2 | H330 | GHS06 |
| Skin corrosion/irritation GHS chapter 3.2 | Category 1A or 1B or 1C | H314 | GHS05 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 1 | H318 | GHS05 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Methylisothiazolinone hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H330 | Fatal if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H314 | Causes severe skin burns and eye damage. |
| H318 | Causes serious eye damage. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
Methylisothiazolinone supplemental EU statements (EUH)
| Code | Statement |
|---|---|
| EUH071 | Corrosive to the respiratory tract. |
This page lists only the codes assigned to Methylisothiazolinone. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Methylisothiazolinone
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Methylisothiazolinone issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Methylisothiazolinone precautionary statements
CLP Annex VI assigns 20 precautionary statements to Methylisothiazolinone. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Methylisothiazolinone name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 2-метилизотиазол-3(2 H )-он |
| Spanish español | 2-Metilisotiazol-3(2 H )-ona |
| Czech čeština | 2-methylisothiazol-3(2 H )-on |
| Danish dansk | 2-methylisothiazol-3(2 H )-on |
| German Deutsch | 2-Methyl-2 H -isothiazol-3-on |
| Estonian eesti | 2-metüülisotiasool-3(2 H )-oon |
| Greek ελληνικά | 2-μεθυλισοθειαζολ-3(2 H )-όνη |
| English English | 2-methylisothiazol-3(2 H )-one |
| French français | 2-méthylisothiazol-3(2 H )-one |
| Croatian hrvatski | 2-metilizotiazol-3(2 H )-on |
| Italian italiano | 2-metilisotiazol-3(2 H )-one |
| Latvian latviešu | 2-metilizotiazol-3(2 H )-ons |
| Lithuanian lietuvių | 2-metilizotiazol-3(2 H )-onas |
| Hungarian magyar | 2-metilisotiazol-3(2 H )-on |
| Maltese Malti | 2-metilisotiazol-3(2 H )-on |
| Dutch Nederlands | 2-methylisothiazool-3(2 H )-on |
| Polish polski | 2-metyloizotiazol-3(2 H )-on |
| Portuguese português | 2-metilisotiazol-3(2H)-ona |
| Romanian română | 2-metilizotiazol-3(2 H )-onă |
| Slovak slovenčina | 2-metyl-2 H -izotiazol-3-ón |
| Slovenian slovenščina | 2-metilizotiazol-3(2 H )-on |
| Finnish suomi | 2-metyyli-isotiatsol-3(2 H )-oni |
| Swedish svenska | 2-metylisotiazol-3(2 H )-on |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Methylisothiazolinone GHS label elements
Everything CLP Annex VI fixes for Methylisothiazolinone, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Methylisothiazolinone
- Fatal if inhaled.
- Toxic in contact with skin.
- Toxic if swallowed.
- Causes severe skin burns and eye damage.
- Causes serious eye damage.
- May cause an allergic skin reaction.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Corrosive to the respiratory tract.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Use only outdoors or in a well-ventilated area.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF ON SKIN:
- IF INHALED:
- IF IN EYES:
- Immediately call a POISON CENTER/doctor/…
- Get medical advice/attention.
- Rinse mouth.
- Do NOT induce vomiting.
- If skin irritation or rash occurs:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Methylisothiazolinone in the GHS label constructor →
07 · Health hazards
Methylisothiazolinone health hazards and exposure limits
Methylisothiazolinone hazard summary
Allergic contact dermatitis reported in workers using products containing this preservative; [Kanerva, p. 1815] Danger of skin sensitization; [MAK] Cosmetic preservative that is a recognized contact allergen in consumers; [EC: SCCS - Opinion] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May cause skin sensitization; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS] See ISOTHIAZOLINONES.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
08 · Physical and chemical properties
Methylisothiazolinone properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Methylisothiazolinone boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 93 °C (199.4 °F) | at 0.03 mmHg (reduced pressure) | HSDB |
Methylisothiazolinone melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 50.5 °C (122.9 °F) | range, midpoint shown | HSDB |
Methylisothiazolinone density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.19 g/cm³ | at 20 °C | HSDB |
| 1.35 g/cm³ | at 25 °C | HSDB |
Methylisothiazolinone solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Solubility in: acetonitrile 78.6; methanol 79.1; hexane 2.371; xylenol 15.65 (g/100 mL) | HSDB |
Methylisothiazolinone vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.062 mmHg | at 25 °C | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
Methylisothiazolinone storage and handling
Methylisothiazolinone storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Source: Hazardous Substances Data Bank (HSDB)
Methylisothiazolinone incompatible materials
Materials to avoid: Strong oxidizing agents, Amines, Mercaptans, Reducing agents.
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Methylisothiazolinone in the storage compatibility matrix →
10 · Questions
Methylisothiazolinone — frequently asked questions
What is the CAS number of Methylisothiazolinone?
The CAS number of Methylisothiazolinone is 2682-20-4. Its EC number is 220-239-6.
What is the chemical formula of Methylisothiazolinone?
The molecular formula of Methylisothiazolinone is C4H5NOS and its molecular weight is 115.16 g/mol.
What does a Methylisothiazolinone label have to show?
Under CLP Annex VI the label for Methylisothiazolinone carries the pictograms Corrosion, Skull and crossbones and Environment and the signal word is Danger.
Is Methylisothiazolinone flammable?
CLP Annex VI assigns Methylisothiazolinone no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is Methylisothiazolinone a carcinogen?
CLP Annex VI records no harmonised carcinogenicity classification for Methylisothiazolinone. Annex VI is a list of agreed classifications, not a list of substances found safe, so this is an absence of a classification rather than a clean bill of health.
What is the boiling point of Methylisothiazolinone?
The boiling point reported for Methylisothiazolinone is 93 °C (199.4 °F), at 0.03 mmHg (reduced pressure) (HSDB).
What is the melting point of Methylisothiazolinone?
The melting point reported for Methylisothiazolinone is 50.5 °C (122.9 °F), range, midpoint shown (HSDB).
How should Methylisothiazolinone be stored?
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. (Hazardous Substances Data Bank (HSDB))
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