Substance profile
N-2-naphthylaniline
N-2-naphthylaniline is needles from methanol.
01 · Identification
What N-2-naphthylaniline is
N-2-naphthylaniline is needles from methanol. Its molecular formula is C16H13N and its molecular weight is 219.28 g/mol. It boils at 396 °C, melts at 108 °C, is practically insoluble in water.
Under the GHS it carries the signal word Warning.
02 · Identifiers
N-2-naphthylaniline identifiers and molecular data
N-2-naphthylaniline CAS number and EC number
N-2-naphthylaniline molecular formula and molecular weight
Other names for N-2-naphthylaniline
- N-phenyl-2-naphthylamine
03 · GHS classification
N-2-naphthylaniline hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
N-2-naphthylaniline pictograms and signal word
N-2-naphthylaniline hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Skin corrosion/irritation GHS chapter 3.2 | Category 2 | H315 | GHS07 |
| Serious eye damage/eye irritation GHS chapter 3.3 | Category 2A | H319 | GHS07 |
| Skin sensitisation GHS chapter 3.4 | Category 1 or 1A or 1B | H317 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 2 | H351 | GHS08 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 2 | H411 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
N-2-naphthylaniline hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H317 | May cause an allergic skin reaction. |
| H411 | Toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to N-2-naphthylaniline. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for N-2-naphthylaniline
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of N-2-naphthylaniline issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
N-2-naphthylaniline precautionary statements
CLP Annex VI assigns 17 precautionary statements to N-2-naphthylaniline. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
N-2-naphthylaniline name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | N -2-нафтиланилин N -фенил-2-нафтиламин |
| Spanish español | N -2-Naftilanilina N -fenil-2-naftilamina |
| Czech čeština | N -(2-naftyl)anilin N -fenyl-2-naftylamin |
| Danish dansk | N- 2-naphthylanilin N- phenyl-2-napthylamin |
| German Deutsch | N -2-Naphthylanilin N -Phenyl-2-naphthylamin |
| Estonian eesti | N- 2-naftüülaniliin N -fenüül-2-naftüülamiin |
| Greek ελληνικά | Ν -2-ναφθυλανιλίνη N -φαινυλο-2-ναφθυλαμίνη |
| English English | N -2-naphthylaniline N -phenyl-2-naphthylamine |
| French français | N -2-naphthylaniline N -phényl-2-naphthylamine |
| Croatian hrvatski | N -2-naftilanilin N -fenil-2-naftilamin |
| Italian italiano | N -2-naftilanilina N -fenil-2-naftilamina |
| Latvian latviešu | N -2-naftilanilīns N -fenil-2-naftilamīns |
| Lithuanian lietuvių | N -2-naftilanilinas N -fenil-2-naftilaminas |
| Hungarian magyar | N -2-naftilanilin N -fenil-2-naftilamin |
| Maltese Malti | N -2-naftilanilina N -fenil-2-naftilammina |
| Dutch Nederlands | N -2-naftylaniline N -fenyl-2-naftylamine |
| Polish polski | N-2-naftyloanilina N-fenylo-2-naftyloaminafenylo(2-naftylo)amina |
| Portuguese português | N -2-naftilanilina N -fenil-2-naftilamina |
| Romanian română | N -2-naftilanilină N -fenil-2-naftilamină |
| Slovak slovenčina | N -fenyl-2-naftylamín N -fenylnaftalén-2-amín |
| Slovenian slovenščina | N -2-naftilanilin N -fenil-2-naftilamin |
| Finnish suomi | N -2-naftyylianiliini N -fenyylinaftyyli-2-amiini |
| Swedish svenska | N -2-naftylanilin N -fenyl-2-naftylamin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
N-2-naphthylaniline GHS label elements
Everything CLP Annex VI fixes for N-2-naphthylaniline, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Warning
N-2-naphthylaniline
- Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes skin irritation.
- Causes serious eye irritation.
- May cause an allergic skin reaction.
- Toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Avoid breathing dust/fume/gas/mist/vapours/spray.
- Wash … thoroughly after handling.
- Contaminated work clothing should not be allowed out of the workplace.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF ON SKIN:
- IF IN EYES:
- IF exposed or concerned:
- Get medical advice/attention.
- If skin irritation occurs:
- If skin irritation or rash occurs:
- If eye irritation persists:
- Remove contact lenses, if present and easy to do. Continue rinsing.
- Wash with plenty of water/…
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open N-2-naphthylaniline in the GHS label constructor →
07 · Health hazards
N-2-naphthylaniline health hazards and exposure limits
N-2-naphthylaniline hazard summary
Allergic contact dermatitis reported in rubber workers; [Kanerva, p. 1826] Danger of skin sensitization; [MAK]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
N-2-naphthylaniline carcinogenicity classification
Under the conditions of these 2-year feed studies, there was no evidence of carcinogenic activity for male or female F344/N rats fed diets containing 2,500 or 5,000 ppm N-phenyl-2-naphthylamine. Decreased incidences of several neoplasms were observed in dosed rats: thyroid gland C-cell neoplasms in males and females and mononuclear cell leukemia, pituitary gland adenomas, and mammary gland fibroadenomas in females. There was no evidence of carcinogenic activity for male B6C3F1 mice fed diets containing 2,500 or 5,000 ppm N-phenyl-2-naphthylamine. There was equivocal evidence of carcinogenic activity of N-phenyl-2-naphthylamine for female B6C3F1 mice as indicated by the occurrence of two rare kidney neoplasms. Chemical-related nonneoplastic lesions (nephropathy, karyomegaly, and hyperplasia) occurred in the kidney of rats and mice.
Source: US National Toxicology Program · TR-333: Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1988 )
Inadequate evidence of carcinogenicity in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
N-2-naphthylaniline occupational exposure limits
| Limit | Value | Source |
|---|---|---|
| PEL | none | The National Institute for Occupational Safety and Health (NIOSH) |
| REL | Ca* See Appendix A [*Note: Since metabolized to β-Naphthylamine.] | The National Institute for Occupational Safety and Health (NIOSH) |
| IDLH | A potential occupational carcinogen. (NIOSH, 2024) | CAMEO Chemicals |
| IDLH | NIOSH considers N-phenyl-beta-naphthylamine to be a potential occupational carcinogen. [Note: Since metabolized to beta-Naphthylamine]. | Hazardous Substances Data Bank (HSDB) |
| IDLH | Ca [N.D.] | The National Institute for Occupational Safety and Health (NIOSH) |
These are United States values. The European Union sets its own indicative and binding limits, and the figure that applies at a given workplace is the one in the local regulation — not the one shown here.
08 · Physical and chemical properties
N-2-naphthylaniline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
N-2-naphthylaniline boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 395.5 °C (743.9 °F) | HSDB | |
| 395 °C (743 °F) | NIOSH | ||
| 395 °C (743 °F) | at 760 mmHg | CAMEO |
N-2-naphthylaniline melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 108 °C (226.4 °F) | HSDB | |
| 107.78 °C (226 °F) | NIOSH |
N-2-naphthylaniline density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.24 g/cm³ | HSDB |
N-2-naphthylaniline solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | SOLUBILITY IN ETHANOL 50 G/L, IN BENZENE 27 G/L, IN ACETONE 640 G/L | HSDB | |
| INSOL IN WATER; SOL IN ALC, ETHER, ACETIC ACID (BLUISH FLUORESCENCE) | HSDB | ||
| Insoluble | NIOSH |
N-2-naphthylaniline vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.00000829 mmHg | Haz-Map |
N-2-naphthylaniline lower explosive limit (LEL)
| Property | Value | Conditions | Source |
|---|---|---|---|
| Lower explosive limit (LEL) | Combustible Solid | NIOSH |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
N-2-naphthylaniline fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
N-2-naphthylaniline fire potential
FIRE HAZARD: MODERATE, WHEN EXPOSED TO HEAT OR FLAME... CAN REACT WITH OXIDIZING MATERIALS.
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
N-2-naphthylaniline storage and handling
N-2-naphthylaniline safe storage
Separated from oxidants. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
N-2-naphthylaniline storage conditions
...MATERIALS WHICH ARE TOXIC AS STORED OR WHICH...DECOMP INTO TOXIC COMPONENTS DUE TO CONTACT WITH HEAT...SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, &...PERIODICALLY INSPECTED & MONITORED.
Source: Hazardous Substances Data Bank (HSDB)
N-2-naphthylaniline incompatible materials
Oxidizers.
Source: Hazardous Substances Data Bank (HSDB)
N-2-naphthylaniline reactivity
N-PHENYL-2-NAPHTHYLAMINE may react with strong oxidizing agents (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check N-2-naphthylaniline in the storage compatibility matrix →
11 · Questions
N-2-naphthylaniline — frequently asked questions
What is the CAS number of N-2-naphthylaniline?
The CAS number of N-2-naphthylaniline is 135-88-6. Its EC number is 205-223-9.
What is the chemical formula of N-2-naphthylaniline?
The molecular formula of N-2-naphthylaniline is C16H13N and its molecular weight is 219.28 g/mol.
What does a N-2-naphthylaniline label have to show?
Under CLP Annex VI the label for N-2-naphthylaniline carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Warning.
Is N-2-naphthylaniline flammable?
CLP Annex VI assigns N-2-naphthylaniline no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is N-2-naphthylaniline a carcinogen?
CLP Annex VI assigns N-2-naphthylaniline H351 — suspected of causing cancer. That is category 2: the evidence points that way but is not conclusive. IARC places it in Group 3: not classifiable as to its carcinogenicity to humans.
What is the exposure limit for N-2-naphthylaniline?
The US occupational exposure limit reported for N-2-naphthylaniline is none (The National Institute for Occupational Safety and Health (NIOSH)). Limits differ by country: the EU sets its own indicative and binding values, and the figure that applies at a given workplace is the one in the local regulation.
What is the boiling point of N-2-naphthylaniline?
The boiling point reported for N-2-naphthylaniline is 395.5 °C (743.9 °F) (HSDB).
What is the melting point of N-2-naphthylaniline?
The melting point reported for N-2-naphthylaniline is 108 °C (226.4 °F) (HSDB).
How should N-2-naphthylaniline be stored?
...MATERIALS WHICH ARE TOXIC AS STORED OR WHICH...DECOMP INTO TOXIC COMPONENTS DUE TO CONTACT WITH HEAT...SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, &...PERIODICALLY INSPECTED & MONITORED. (Hazardous Substances Data Bank (HSDB))
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