Substance profile
N,N,N',N'-tetramethyl-4,4'-methylendianiline
N,N,N',N'-tetramethyl-4,4'-methylendianiline is lustrous leaflets.
01 · Identification
What N,N,N',N'-tetramethyl-4,4'-met… is
N,N,N',N'-tetramethyl-4,4'-methylendianiline is lustrous leaflets. Its molecular formula is C17H22N2 and its molecular weight is 254.37 g/mol. It boils at 390 °C, melts at 91.5 °C, is practically insoluble in water.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
N,N,N',N'-tetramethyl-4,4'-met… identifiers and molecular data
N,N,N',N'-tetramethyl-4,4'-met… CAS number and EC number
N,N,N',N'-tetramethyl-4,4'-met… molecular formula and molecular weight
03 · GHS classification
N,N,N',N'-tetramethyl-4,4'-met… hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
N,N,N',N'-tetramethyl-4,4'-met… pictograms and signal word
N,N,N',N'-tetramethyl-4,4'-met… hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
N,N,N',N'-tetramethyl-4,4'-met… hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to N,N,N',N'-tetramethyl-4,4'…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for N,N,N',N'-tetramethyl-4,4'…
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of N,N,N',N'-tetramethyl… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
N,N,N',N'-tetramethyl-4,4'-met… precautionary statements
CLP Annex VI assigns 7 precautionary statements to N,N,N',N'-tetramethyl-4,4'…. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
N,N,N',N'-tetramethyl-4,4'-met… name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | N , N , N ′, N ′-тетраметил-4,4′-метилендианилин |
| Spanish español | N , N , N ', N '-Tetrametil-4,4'-metilendianilina |
| Czech čeština | N, N,N',N' -tetramethyl-4,4'-methylendianilin |
| Danish dansk | N, N,N' , N' -tetramethyl-4,4'-methylendianilin |
| German Deutsch | N , N , N ', N '-Tetramethyl-4,4'-methylendianilin |
| Estonian eesti | N , N , N ′, N ′-tetrametüül-4,4′-metüleendianiliin |
| Greek ελληνικά | N , N , N ′, N ′-τετραμεθυλο-4,4′-μεθυλενοδιανιλίνη |
| English English | N , N , N ', N '-tetramethyl-4,4'-methylendianiline |
| French français | N , N , N ', N '-tétraméthyl-4,4'-méthylènedianiline |
| Croatian hrvatski | N , N , N ', N '-tetrametil-4,4'-metilendianilin |
| Italian italiano | N, N,N',N'- tetrametil-4,4'-metilendianilina |
| Latvian latviešu | N , N , N ', N '-tetrametil-4,4'-metilēndianilīns |
| Lithuanian lietuvių | N , N , N ', N '-tetrametil-4,4'-metilendianilinas |
| Hungarian magyar | N , N , N ', N '-tetrametil-4,4'-metiléndianilin |
| Maltese Malti | N , N , N ', N '-tetrametil-4,4'-metilendianilina |
| Dutch Nederlands | N , N , N ', N '-tetramethyl-4,4'-methyleendianiline |
| Polish polski | N , N , N ', N '-tetrametylo-4,4'-metylenodianilina |
| Portuguese português | N , N , N ', N '-tetrametil-4,4'-metilenodianilina |
| Romanian română | N , N , N ', N '-tetrametil-4,4'-metilendianilină |
| Slovak slovenčina | N , N , N ', N '-tetrametyl-4,4'-metyléndianilín |
| Slovenian slovenščina | N , N , N ', N '-tetrametil-4,4'-metilendianilin |
| Finnish suomi | N , N , N ', N '-tetrametyyli-4,4’-metyleenidianiliini |
| Swedish svenska | N , N , N ', N '-tetrametyl-4,4'-metylendianilin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
N,N,N',N'-tetramethyl-4,4'-met… GHS label elements
Everything CLP Annex VI fixes for N,N,N',N'-tetramethyl-4,4'…, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
N,N,N',N'-tetramethyl-4,4'-met…
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open N,N,N',N'-tetramethyl-4,4'… in the GHS label constructor →
07 · Health hazards
N,N,N',N'-tetramethyl-4,4'-met… health hazards and exposure limits
N,N,N',N'-tetramethyl-4,4'-met… hazard summary
A skin, eye, and respiratory tract irritant; Harmful by inhalation, ingestion, and skin absorption; Can cause injury to the liver, kidneys, lungs, and reproductive system; [CAMEO] An irritant; May induce methemoglobinemia; [MSDSonline]
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
N,N,N',N'-tetramethyl-4,4'-met… carcinogenicity classification
Under the conditions of this bioassay, 4,4'-methylenebis-(N,N-dimethyl)benzeneamine was carcinogenic in Fisher 344 rats, inducing thyroid follicular-cell carcinomas in both males and females. Administration of the compound was carcinogenic in female B6C3F1 mice, inducing liver neoplasms. There was no conclusive evidence that 4,4'-methylenebis-(N,N-dimethyl)benzeneamine was carcinogenic in male B6C3F1 mice.
Source: US National Toxicology Program · TR-186: Bioassay of 4,4'-Methylenebis-(N,N-dimethyl)benzeneamine for Possible Carcinogenicity (CASRN 101-61-1) (1979 )
No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Sufficient evidence from animal experiments: thyroid tumors in male and female rats, and liver carcinoma/adenoma in the female mice with significant positive trend in male mice. There is evidence of mutagenic activity. There are no human data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Sufficient.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
N,N,N',N'-tetramethyl-4,4'-met… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
N,N,N',N'-tetramethyl-4,4'-met… boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 390 °C (734 °F) | at 760 mmHg | CAMEO |
| 390 °C (734 °F) | decomposes | HSDB | |
| 183 °C (361.4 °F) | at 3 mmHg (reduced pressure) | HSDB |
N,N,N',N'-tetramethyl-4,4'-met… melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 91.5 °C (196.7 °F) | HSDB | |
| 90.56 °C (195 °F) | range, midpoint shown | CAMEO |
N,N,N',N'-tetramethyl-4,4'-met… density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.14 g/cm³ | at 20 °C | CAMEO |
N,N,N',N'-tetramethyl-4,4'-met… solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Insoluble in water | HSDB | |
| Soluble in benzene, ether, carbon disulfide, acids; slightly soluble in cold alcohol, more soluble in hot alcohol | HSDB | ||
| Slightly soluble in ethanol; soluble in acid; very soluble in ether, benzene, carbon disulfide | HSDB |
N,N,N',N'-tetramethyl-4,4'-met… vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 0.000075 mmHg | below this value, at 20 °C | CAMEO |
| 0.0000175 mmHg | Haz-Map |
N,N,N',N'-tetramethyl-4,4'-met… flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 211.11 °C (412 °F) | CAMEO | |
| 211 °C (411.8 °F) | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
N,N,N',N'-tetramethyl-4,4'… fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
N,N,N',N'-tetramethyl-4,4'-met… fire potential
Flammable liquid
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
N,N,N',N'-tetramethyl-4,4'-met… storage and handling
N,N,N',N'-tetramethyl-4,4'-met… reactivity
4,4'-METHYLENEBIS(N,N-DIMETHYL)BENZENAMINE is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. It is also incompatible with active metals, potassium, oxides, chlorates, halogenated compounds, iron chloride, nitro compounds, peroxides, strong ammonia solutions, sulfides and vinyl polymers (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check N,N,N',N'-tetramethyl-4,4… in the storage compatibility matrix →
11 · Questions
N,N,N',N'-tetramethyl-4,4'-met… — frequently asked questions
What is the CAS number of N,N,N',N'-tetramethyl-4,4'-met…?
The CAS number of N,N,N',N'-tetramethyl-4,4'-met… is 101-61-1. Its EC number is 202-959-2.
What is the chemical formula of N,N,N',N'-tetramethyl-4,4'-met…?
The molecular formula of N,N,N',N'-tetramethyl-4,4'-met… is C17H22N2 and its molecular weight is 254.37 g/mol.
What does a N,N,N',N'-tetramethyl-4,4'-met… label have to show?
Under CLP Annex VI the label for N,N,N',N'-tetramethyl-4,4'-met… carries the pictograms Health hazard and Environment and the signal word is Danger.
Is N,N,N',N'-tetramethyl-4,4'-met… flammable?
CLP Annex VI assigns N,N,N',N'-tetramethyl-4,4'-met… no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 211.11 °C (412 °F) (CAMEO).
Is N,N,N',N'-tetramethyl-4,4'-met… a carcinogen?
Yes. CLP Annex VI classifies N,N,N',N'-tetramethyl-4,4'-met… as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of N,N,N',N'-tetramethyl-4,4'-met…?
The boiling point reported for N,N,N',N'-tetramethyl-4,4'-met… is 390 °C (734 °F), at 760 mmHg (CAMEO).
What is the melting point of N,N,N',N'-tetramethyl-4,4'-met…?
The melting point reported for N,N,N',N'-tetramethyl-4,4'-met… is 91.5 °C (196.7 °F) (HSDB).
Nearby
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