Substance profile
N-Nitrosomorpholine
N-Nitrosomorpholine is yellow crystals.
01 · Identification
What N-Nitrosomorpholine is
N-Nitrosomorpholine is yellow crystals. It boils at 224 °C, melts at 29 °C, is soluble in water.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
02 · Identifiers
N-Nitrosomorpholine identifiers and molecular data
N-Nitrosomorpholine CAS number and EC number
N-Nitrosomorpholine molecular formula and molecular weight
Other names for N-Nitrosomorpholine
- 4-nitrosomorpholine
03 · GHS classification
N-Nitrosomorpholine hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
N-Nitrosomorpholine pictograms and signal word
N-Nitrosomorpholine hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Germ cell mutagenicity GHS chapter 3.5 | Category 2 | H341 | GHS08 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Specific target organ toxicity - repeated exposure GHS chapter 3.9 | Category 1 | H372 | GHS08 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
N-Nitrosomorpholine hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H372 | Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
This page lists only the codes assigned to N-Nitrosomorpholine. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for N-Nitrosomorpholine
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of N-Nitrosomorpholine issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
N-Nitrosomorpholine precautionary statements
CLP Annex VI assigns 7 precautionary statements to N-Nitrosomorpholine. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
N-Nitrosomorpholine name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | 4-нитрозоморфолин |
| Spanish español | 4-Nitrosomorfolina |
| Czech čeština | 4-nitrosomorfolin |
| Danish dansk | 4-nitrosomorpholin |
| German Deutsch | 4-Nitrosomorpholin |
| Estonian eesti | 4-nitrosomorfoliin |
| Greek ελληνικά | 4- νιτρωδομορφολίνη |
| English English | 4-nitrosomorpholine |
| French français | 4-nitrosomorpholine |
| Croatian hrvatski | 4-nitrozomorfolin |
| Italian italiano | 4-nitrosomorfolina |
| Latvian latviešu | 4-nitrosomorfolīns |
| Lithuanian lietuvių | 4-nitrosomorfolinas |
| Hungarian magyar | 4-nitrozomorfolin |
| Maltese Malti | 4-nitrosomorfolina |
| Dutch Nederlands | 4-nitrosomorfoline |
| Polish polski | 4-nitrozomorfolina |
| Portuguese português | 4-nitrosomorfolina |
| Romanian română | 4-nitrosomorfolină |
| Slovak slovenčina | 4-nitrózomorfolín |
| Slovenian slovenščina | 4-nitrozomorfolin |
| Finnish suomi | 4-nitrosomorfoliini |
| Swedish svenska | 4-nitrosomorfolin |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
N-Nitrosomorpholine GHS label elements
Everything CLP Annex VI fixes for N-Nitrosomorpholine, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
N-Nitrosomorpholine
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Obtain special instructions before use.
- Do not breathe dust/fume/gas/mist/vapours/spray.
- Do not eat, drink or smoke when using this product.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF exposed or concerned:
- Get medical advice/attention.
- Get medical advice/attention if you feel unwell.
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open N-Nitrosomorpholine in the GHS label constructor →
07 · Health hazards
N-Nitrosomorpholine health hazards and exposure limits
N-Nitrosomorpholine hazard summary
N-Nitrosomorpholine is not used commercially in the United States. Limited information is available on the health effects of N-nitrosomorpholine. No information is available on the acute (short-term), chronic (long-term), reproductive, developmental, or carcinogenic effects of N-nitrosomorpholine in humans. Animal studies have reported effects on the liver from chronic exposure as well as tumors of the liver, nasal cavity, lung, and kidneys from oral exposure to N-nitrosomorpholine. EPA has not classified N- nitrosomorpholine for carcinogenicity. The International Agency for Research on Cancer (IARC) has classified N-nitrosomorpholine as a Group 2B, possible human carcinogen.
Source: EPA Hazardous Air Pollutants
N-Nitrosomorpholine carcinogenicity classification
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
N-Nitrosomorpholine: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
N-Nitrosomorpholine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
N-Nitrosomorpholine boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 223.89 °C (435 °F) | at 747 mmHg | OSHA |
| 225 °C (437 °F) | at 760 mmHg | DOE PAC | |
| 224.25 °C (435.7 °F) | range, midpoint shown, at 747 mmHg | HSDB |
N-Nitrosomorpholine melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 29 °C (84.2 °F) | HSDB | |
| 28.89 °C (84 °F) | CAMEO |
N-Nitrosomorpholine solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | Soluble in organic solvents | HSDB | |
| Miscible in water in all proportions | HSDB | ||
| greater than or equal to 100 mg/mL at 66 °F (NTP, 1992) | at 18.89 °C | CAMEO |
N-Nitrosomorpholine vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 25 mmHg | CAMEO | |
| 0.03 mmHg | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Handling and storage
N-Nitrosomorpholine storage and handling
N-Nitrosomorpholine storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
N-Nitrosomorpholine reactivity
N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check N-Nitrosomorpholine in the storage compatibility matrix →
10 · Questions
N-Nitrosomorpholine — frequently asked questions
What is the CAS number of N-Nitrosomorpholine?
The CAS number of N-Nitrosomorpholine is 59-89-2.
What does a N-Nitrosomorpholine label have to show?
Under CLP Annex VI the label for N-Nitrosomorpholine carries the pictogram Health hazard and the signal word is Danger.
Is N-Nitrosomorpholine flammable?
CLP Annex VI assigns N-Nitrosomorpholine no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it.
Is N-Nitrosomorpholine a carcinogen?
Yes. CLP Annex VI classifies N-Nitrosomorpholine as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of N-Nitrosomorpholine?
The boiling point reported for N-Nitrosomorpholine is 223.89 °C (435 °F), at 747 mmHg (OSHA).
What is the melting point of N-Nitrosomorpholine?
The melting point reported for N-Nitrosomorpholine is 29 °C (84.2 °F) (HSDB).
How should N-Nitrosomorpholine be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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