Substance profile
Nitrofen
Nitrofen is a crystalline solid.
01 · Identification
What Nitrofen is
Nitrofen is a crystalline solid. Its molecular formula is C12H7Cl2NO3 and its molecular weight is 284.09 g/mol. It boils at 368 °C, melts at 70.5 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · Identifiers
Nitrofen identifiers and molecular data
Nitrofen CAS number and EC number
Nitrofen molecular formula and molecular weight
Other names for Nitrofen
- nitrofen (ISO)
- 2,4-dichlorophenyl 4-nitrophenyl ether
03 · GHS classification
Nitrofen hazard classification
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
Nitrofen pictograms and signal word
Nitrofen hazard class and category
| Hazard class | Category | From code | Pictogram |
|---|---|---|---|
| Acute toxicity - oral GHS chapter 3.1 | Category 4 | H302 | GHS07 |
| Carcinogenicity GHS chapter 3.6 | Category 1A or 1B | H350 | GHS08 |
| Hazardous to the aquatic environment - acute GHS chapter 4.1 | Category 1 | H400 | GHS09 |
| Hazardous to the aquatic environment - chronic GHS chapter 4.1 | Category 1 | H410 | GHS09 |
Where two values are shown with “or”, the hazard statement is shared by more than one category or by more than one class, and the code alone does not say which. H272, for example, belongs to oxidising liquids and to oxidising solids — the physical state decides. The binding answer for a specific entry is in the CLP Annex VI table itself.
Nitrofen hazard statements (H-codes)
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H360D | May damage the unborn child. |
| H302 | Harmful if swallowed. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
This page lists only the codes assigned to Nitrofen. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.
Safety Data Sheet
Getting an SDS for Nitrofen
A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of Nitrofen issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.
04 · Precautionary statements
Nitrofen precautionary statements
CLP Annex VI assigns 11 precautionary statements to Nitrofen. They are grouped the way a label groups them: what to do before handling, what to do when something has already happened, how to store it and how to dispose of it.
Prevention
What to do before and during handling so the hazard never happens.
Response
What to do once exposure, spillage or fire has already happened.
Disposal
What has to happen to the contents and the empty container.
Reading the notation. … is a blank the supplier fills in — not a truncated sentence.· [square brackets] mark a part printed only when it applies.
05 · Names in the regulation
Nitrofen name in 23 EU languages
CLP Annex VI Part 3 is published in every language edition of the regulation, and the identification column is written out in each of them. Nothing below is translated by us: each line is the name as that edition prints it. Under Art. 18(2) the substance name from Annex VI is a lawful product identifier, so this is the wording to put on a label going to that market — and where the cell lists several designations, any one of them qualifies.
| Language | Name in CLP Annex VI Part 3 |
|---|---|
| Bulgarian български | нитрофен (ISO) 4-нитрофенил-2,4-дихлорофенилов етер |
| Spanish español | Nitrofeno (ISO) éter de 2,4-diclorofenilo y 4-nitrofenilo |
| Czech čeština | nitrofen (ISO) (2,4-dichlorfenyl)(4-nitrofenyl)ether |
| Danish dansk | nitrofen (ISO) 2,4-dichlorphenyl-4-nitrophenylether |
| German Deutsch | Nitrofen (ISO) 2,4-Dichlorpheny-4-nitrophenylether |
| Estonian eesti | nitrofeen (ISO) 2,4-diklorofenüül-4-nitrofenüüleeter |
| Greek ελληνικά | nitrofen (νιτροφαίνη) (ISO) 2,4-διχλωροφαινυλο-4-νιτροφαινυλαιθέρας |
| English English | nitrofen (ISO) 2,4-dichlorophenyl 4-nitrophenyl ether |
| French français | nitrofène (ISO) oxyde de 2,4-dichlorophényle et de 4-nitrophényle |
| Croatian hrvatski | nitrofen (ISO) 2,4-diklorfenil 4-nitrofenil eter |
| Italian italiano | nitrofen (ISO) ossido di 2,4-diclorofenile e 4-nitrofenile |
| Latvian latviešu | nitrofēns (ISO) (2,4-dihlorfenil)(4-nitrofenil)ēteris |
| Lithuanian lietuvių | nitrofenas (ISO) 2,4-dichlorfenil 4-nitrofenileteris |
| Hungarian magyar | nitrofen (ISO) 2,4-diklórfenil-4-nitrofenil-éter |
| Maltese Malti | nitrofen (ISO) etere 2,4-diklorofenil 4-nitrofenil |
| Dutch Nederlands | nitrofen (ISO) 2,4-dichloorfenyl-4-nitrofenylether |
| Polish polski | nitrofen (ISO) eter 2,4-dichlorofenylowo-4-nitrofenylowy |
| Portuguese português | nitrofena (ISO) éter 2,4-diclorofenílico e 4-nitrofenílico |
| Romanian română | nitrofen (ISO) 2,4-diclorfenil-4-nitrofenil-eter |
| Slovak slovenčina | nitrofén (ISO) 2,4-dichlórfenyl(4-nitrofenyl)éter |
| Slovenian slovenščina | nitrofen (ISO) 2,4-diklorofenil 4-nitrofenilni eter |
| Finnish suomi | nitrofeeni (ISO) 2,4-dikloorifenyyli-4-nitrofenyylieetteri |
| Swedish svenska | nitrofen (ISO) 2,4-diklorfenyl-4-nitrofenyleter |
All 23 language editions of Annex VI carry this entry. Irish is the twenty-fourth official EU language and has no line here for a different reason: no consolidated CLP text has ever been published in Irish, so there is no Irish edition of Annex VI to quote a name from. Source: consolidated CLP, CELEX 02008R1272, language editions. © European Union, https://eur-lex.europa.eu — only the electronic Official Journal of the European Union is authentic.
06 · Label elements
Nitrofen GHS label elements
Everything CLP Annex VI fixes for Nitrofen, laid out the way it appears on a label. The greyed lines are the parts only the supplier can fill in.
Danger
Nitrofen
- May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- May damage the unborn child.
- Harmful if swallowed.
- Very toxic to aquatic life.
- Very toxic to aquatic life with long lasting effects.
- Obtain special instructions before use.
- Do not eat, drink or smoke when using this product.
- Avoid release to the environment.
- Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
- IF SWALLOWED:
- IF exposed or concerned:
- Call a POISON CENTER/doctor/… if you feel unwell.
- Get medical advice/attention.
- Rinse mouth.
- Collect spillage.
- Dispose of contents/container to …
Supplier name, address and telephone number· Product identifier·Nominal quantity
Need this as an actual label? Open Nitrofen in the GHS label constructor →
07 · Health hazards
Nitrofen health hazards and exposure limits
Nitrofen hazard summary
A skin and respiratory tract irritant; May have effect on the CNS and liver and possibly carcinogenic to humans; Animal tests show that this substance possibly causes malformations in human babies. [ICSC] Increase congenital malformations in rodent experiments at levels that were not overtly toxic to mothers; [REPROTOX] May cause skin irritation; [HSDB] May cause skin and eye irritation; [CAMEO] Caused convulsions and coma in a woman who ingested 10 ml/kg; [MSDSonline] See Fluthiacet-methyl.
Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Nitrofen carcinogenicity classification
Under the conditions of this bioassay, dietary administration of nitrofen was carcinogenic to B6C3F1 mice, causing hepatocellular carcinomas in both sexes. There was no evidence for carcinogenicity in Fischer 344 rats.
Source: US National Toxicology Program · TR-184: Bioassay of Nitrofen for Possible Carcinogenicity (CASRN 1836-75-5) (1979 )
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
Source: Hazardous Substances Data Bank (HSDB)
Nitrofen: reasonably anticipated to be a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
An IARC group and a CLP classification answer different questions. IARC judges whether the evidence for cancer in humans is strong enough; CLP Annex VI is the legally binding EU classification. A substance can carry one and not the other.
08 · Physical and chemical properties
Nitrofen properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
Nitrofen boiling point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 368 °C (694.4 °F) | at 759.813 mmHg | ICSC |
| 185 °C (365 °F) | range, midpoint shown, at 0.25 mmHg (reduced pressure) | HSDB |
Nitrofen melting point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 70.5 °C (158.9 °F) | range, midpoint shown | HSDB |
| 70.56 °C (159 °F) | range, midpoint shown | CAMEO |
Nitrofen density
| Property | Value | Conditions | Source |
|---|---|---|---|
| Density | 1.3 g/cm³ | ICSC | |
| 1.33 g/cm³ | at 90 °C | HSDB |
Nitrofen solubility
| Property | Value | Conditions | Source |
|---|---|---|---|
| Solubility | In water, 1.0 mg/L at 22 °C | at 22 °C | HSDB |
| In water, 0.7-1.2 ppm at 22 °C | at 22 °C | HSDB | |
| Soluble in ethanol 40, n-hexane 280, benzene 2000 (all in g/kg at 20 °C) | at 20 °C | HSDB |
Nitrofen vapor pressure
| Property | Value | Conditions | Source |
|---|---|---|---|
| Vapor pressure | 7951 mmHg | at 40 °C | HSDB |
| 0.000008 mmHg | at 40 °C | CAMEO | |
| 0.000007501 mmHg | at 40 °C | ICSC |
Nitrofen flash point
| Property | Value | Conditions | Source |
|---|---|---|---|
| Flash point | 200 °C (392 °F) | above this value | ICSC |
Nitrofen autoignition temperature
| Property | Value | Conditions | Source |
|---|---|---|---|
| Autoignition temperature | 400 °C (752 °F) | above this value | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
09 · Fire and explosion
Nitrofen fire and explosion behaviour
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Nitrofen fire potential
FLAMMABLE
Source: Hazardous Substances Data Bank (HSDB)
10 · Handling and storage
Nitrofen storage and handling
Nitrofen safe storage
Separated from food and feedstuffs. Well closed.
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Nitrofen storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
Nitrofen reactivity
NITROFEN is a nitrated and halogenated ether derivative.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Nitrofen in the storage compatibility matrix →
11 · Questions
Nitrofen — frequently asked questions
What is the CAS number of Nitrofen?
The CAS number of Nitrofen is 1836-75-5. Its EC number is 217-406-0.
What is the chemical formula of Nitrofen?
The molecular formula of Nitrofen is C12H7Cl2NO3 and its molecular weight is 284.09 g/mol.
What does a Nitrofen label have to show?
Under CLP Annex VI the label for Nitrofen carries the pictograms Health hazard, Exclamation mark and Environment and the signal word is Danger.
Is Nitrofen flammable?
CLP Annex VI assigns Nitrofen no flammability hazard class. That is not a statement that it cannot burn: the harmonised list only records the hazards that were assessed for it. The flash point reported for it is 200 °C (392 °F), above this value (ICSC).
Is Nitrofen a carcinogen?
Yes. CLP Annex VI classifies Nitrofen as a category 1A or 1B carcinogen and assigns it H350: may cause cancer. IARC places it in Group 2B: possibly carcinogenic to humans.
What is the boiling point of Nitrofen?
The boiling point reported for Nitrofen is 368 °C (694.4 °F), at 759.813 mmHg (ICSC).
What is the melting point of Nitrofen?
The melting point reported for Nitrofen is 70.5 °C (158.9 °F), range, midpoint shown (HSDB).
How should Nitrofen be stored?
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ (Hazardous Substances Data Bank (HSDB))
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